key: cord-0998533-2m6uwlz1
authors: Rendell, Rebecca; Khazova, Marina; Higlett, Michael; O’Hagan, John
title: Impact of High Solar UV Radiant Exposures in Spring 2020 on SARS‐CoV‐2 Viral Inactivation in the UK
date: 2021-03-05
journal: Photochem Photobiol
DOI: 10.1111/php.13401
sha: 2975a913557d2c860f5b3285872bbdced988cad2
doc_id: 998533
cord_uid: 2m6uwlz1

Potential for SARS‐CoV‐2 viral inactivation by solar UV radiation in outdoor spaces in the UK has been assessed. Average erythema effective and UV‐A daily radiant exposures per month were higher (statistically significant, P < 0.05) in spring 2020 in comparison with spring 2015–2019 across most of the UK, while irradiance generally appeared to be in the normal expected range of 2015–2019. It was found that these higher radiant exposures may have increased the potential for SARS‐CoV‐2 viral inactivation outdoors in April and May 2020. Assessment of the 6‐year period 2015–2020 in the UK found that for 50–60% of the year, that is most of October to March, solar UV is unlikely to have a significant (at least 90% inactivation) impact on viral inactivation outdoors. Minimum times to reach 90% and 99% inactivation in the UK are of the order of tens of minutes and of the order of hours, respectively. However, these times are best case scenarios and should be treated with caution.

Spring 2020 was exceptional in the UK. In the context of the coronavirus disease (COVID-19) pandemic, new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the UK increased rapidly from early March reaching a peak in April and then slowly decreased in May (1) . At the same time, spring 2020 was the sunniest on record (2) , which may have reduced outdoor viral load since solar ultraviolet (UV) radiation, in particular the shortest wavelengths, is the primary virucidal agent in the environment (3) (4) (5) (6) . However, sunshine hours are defined by all incident terrestrial solar radiation wavelengths (7) of which only a small proportion is in the UV wavelength range, so increases in sunshine hours do not provide quantitative information on the increases in the UV region.

Analysis using satellite data (6) shows that solar UV has potential to inactivate viruses from the coronaviridae family and that the level of inactivation varies widely depending on location and season. However, detailed analysis using ground-based data relevant for the UK has not yet been published.

Public Health England (PHE) has a network of ground-based solar monitoring sites across the UK and overseas and additional spectral solar monitoring capabilities at Chilton, UK. These are used for health research and the development of advice regarding sun exposure (8) (9) (10) (11) (12) .

In this paper, ground-based UK solar UV data are analyzed to determine whether significant increases in solar UV were observed in spring 2020 and if so whether this would be likely to have increased viral inactivation outdoors in comparison with spring 2015-2019. Data from the full six-year period 2015-2020 is then analyzed in order to determine the periods when solar UV is likely to contribute to viral inactivation. In addition, the diurnal variation in viral inactivation is considered.

Spring 2020 in the UK was the sunniest on record, with 626 sunshine hours, 71 h greater than the previous record in 1948 (2) and 30% more than the average of the preceding 5 years (13) (see Table 1 ).

Sunshine hours are defined by incident direct solar radiation of > 120 W m À2 (7). Since only a small proportion of terrestrial solar radiation is in the UV wavelength range (280-400 nm), these increases in sunshine hours cannot provide quantitative information on the variation in the UV region.

The PHE solar network sites (14-16) measure UV-A (315-400 nm) and erythema effective irradiances (17) and record these data at five minute intervals. This study utilizes data from eight of the solar network sites in the UK, with latitudes ranging from 50.22°N to 60.14°N, see Fig. 1 .

In order to determine whether there were significant increases in solar UV in spring 2020 in the UK, erythema effective and UV-A daily radiant exposures (doses) were calculated for March-May 2015-2020 for each of the PHE solar monitoring stations. The average daily radiant exposure for each month in spring 2020 was compared to the 2015-2019 average daily radiant exposure for the corresponding month. Statistical significance was calculated using the t-test with a significance level of In order to determine whether increases in solar UV levels in spring 2020 may have increased viral inactivation outdoors in comparison with spring 2015-2019, and to determine periods of the year when solar UV is likely to contribute to viral inactivation, the erythema effective irradiance from the PHE solar network needs to be converted to viral inactivation weighted data.

The viral inactivation action spectrum was determined from (3). Spectral irradiance measured with a Bentham DTMc300 double grating monochromator (Bentham Instruments, Reading, UK) over a wide range of solar elevation angles was used to calculate a conversion from erythema effective irradiance to viral inactivation weighted values by applying erythema (17) and viral inactivation (3) weighting functions to spectral irradiance data. This allowed erythema effective irradiance from the PHE solar network to be converted to viral inactivation weighted irradiance. From these data, times to reach thresholds of inactivation could be determined. The standard inactivation threshold used is D 90 , the fluence threshold for 90% viral inactivation. The D 90 threshold used in this study is 6.9 J m À2 from (18) for 254 nm equivalent UV required for 90% inactivation of SARS-CoV-2. This fluence (spherical surface) threshold has been assumed to be applicable to radiant exposure (flat surface) since particles with potential for person to person transmission will normally be on surfaces or airborne but near the ground with low albedo.

Since 90% viral inactivation may not be sufficient to reduce the risk of infection, 99% inactivation has also been considered. In this study, a D 99 threshold of 27.6 J m À2 has been used-four times the fluence, as given in (18) . The time to reach 6.9 and 27.6 Jm À2 viral inactivation weighted radiant exposures, that is D 90 and D 99 , has been calculated for each month of the year for 2015-2020 under all weather conditions. Time of day is in UTC.

The proportion of days when D 90 and D 99 could be reached in a single whole day and 1 h has been calculated for all sites for 2015-2020. Any years or months with more than 10% or 20% incomplete data respectively have been removed from the analysis. In addition, further detailed analysis on the diurnal variation in the time to reach D 90 and D 99 has been carried out on five days at Chilton. Tables 2 and 3 for mean values, range and the percentage difference between 2020 and 2015-2019 monthly average daily radiant exposures.

Erythema effective radiant exposures are expressed in SEDs (100 J m À2 ) (17).

1 In March, 4 of 8 sites had statistically significant increases in erythema effective daily radiant exposure of 20% or more compared to 2015-2019 average and 4 of 8 sites had statistically significant increases in UV-A daily radiant exposure with three of these being greater than 20%. 2 In April, all sites had statistically significant increases in erythema effective daily radiant exposure of at least 30% compared to 2015-2019 average and 7 of 9 sites had statistically significant increases in UV-A daily radiant exposure with five of these being 20% or more. 3 In May, all sites except Lerwick had statistically significant increases in erythema effective daily radiant exposure of 20% or more compared to 2015-2019 average and five sites had statistically significant increases in UV-A daily radiant exposure with four of these being 20% or more. 4 The sites with the greatest increases in erythema effective daily radiant exposure were Belfast (+57% in April), Camborne (+56% in May) and Inverness (+54% in April). The sites with the greatest increases in UV-A daily radiant exposure were Belfast (+35% in April), London and Camborne (both + 32% in May).

It is notable that the biggest increases were seen at the shortest UV wavelengths, as indicated by the large increases in erythema effective values and that these are greater than the increases seen in UV-A. The shortest UV wavelengths are also significantly more effective in inactivation of viruses (3) .

While UV daily radiant exposures, particularly in April and May 2020, were significantly higher than the 2015-2019 average, monthly maximum erythema effective and UV-A irradiances in spring 2020 were generally in the normal expected range of 2015-2019. For example, the three sites and months with the greatest increase in erythema effective UV daily radiant exposure had either small or negative changes in maximum erythema effective irradiance per month of +3.2%, À9.6% and À4.9% for Belfast (April), Camborne (May) and Inverness (April), respectively. Similarly, the three sites and months with the greatest increase in UV-A daily radiant exposure had small or negative changes in maximum UV-A irradiance per month of +1.6%, À5.9% and À3.3% for Belfast (April), Camborne (May) and London (May), respectively. One exception is Lerwick in March which, although its change in maximum UV-A irradiance is negligible (À1.1%), saw a change in maximum erythema effective irradiance of +45.8% in March 2020. This occurred on the last day of March which is a month where erythema effective irradiance increases rapidly. Specific cloud conditions causing a brief spike in erythema effective irradiance (14) could have contributed to this outlier. The full range of changes to maximum erythema effective irradiance is from À13.5% (London, March) to +18% (Leeds, May) and for UV-A the full range is from À11.9% (Glasgow, May) to +8.2% (Leeds, May).

It is evident that there were significant increases in solar UV in spring 2020 in comparison with spring 2015-2019-however, these were increases in radiant exposure and not irradiance. There was a higher frequency of periods of high irradiance (i.e. more periods of time with clear sunny weather) rather than exceptional increases in peak irradiance. 

For a threshold of reaching D 90 within a day, the significant increases in solar UV radiant exposure in spring 2020 in comparison with spring 2015-2019 appear to have the greatest effect in April ( Fig. 2A , Table 4 ). In March, the proportion of days on which D 90 could be reached within a day was generally < 5% for 2015-2019 and was still < 5% for all sites in 2020. In contrast, by May Viral inactivation during the 6-year period 2015-2020 Figure 3A shows that across a whole year, D 90 could be reached within a day on around 40% of days at the highest UK latitudes and around 50% of days at the lowest UK latitudes. There was larger variation across the latitudes for D 90 being reached within an hour, ranging from 10% to 20% of days per year at the highest latitudes to 30-40% of days at the lowest latitudes (Fig. 3B ). This distribution is very similar for the percentage of days when D 99 could be reached within a day (Fig. 3C) . It was found that D 99 could not be reached within an hour on any day for any site or year in the UK. These findings also show that a viral inactivation threshold of D 90 or greater could not be reached even with a full day of exposure to solar UV for 50-60% of the year (lowest-highest UK latitudes). Across the months of the year, it was found that D 90 could be reached within 1 day from April to September across the UK, with approaching 100% of days reaching this threshold in May, June and Table 4 ) and the number of days when D 90 could be reached in 1 h and D 99 could be reached in 1 day was negligible (mean and range 0.1% (0.0-2.2%) and 0.1% (0.0-1.4%), respectively).

July. Conversely, for most of October-March, and all of November-January, D 90 could not be reached within a day (Fig. 4A) . For reaching D 90 within 1 h or the higher threshold of reaching D 99 within a single day, which show a similar pattern to each other, these thresholds could be reached from April to September at the lower latitudes of the UK for up to around 75% of days. At higher latitudes, these could generally only be reached from May to August for up to around 50% of days ( Fig. 4B and C) . Figure 5 shows the diurnal variation in the time to reach D 90 at Chilton in the south of the UK (see Fig. 1 ) on one clear day in March, April and May 2020, on one variably cloudy day in May 2020 and also on the relatively clear day of 22 June 2020 (very near the summer solstice) which reaches the highest UV Index generally expected to be seen in the UK. Figure 5 shows that the time to reach D 90 is highly dependent on time of day and time of year, with the shorter times to reach D 90 being around or just before noon and on days nearer the summer solstice. Figure 5 also shows that clear, sunny days have greater effectiveness at viral inactivation than cloudy days. It can be seen that the time to reach D 90 on the variably cloudy day with sunny spells of 16 May 2020 is comparable to reach D 90 on the clear day of 23 April 2020, 23 days earlier.

The shortest time to reach D 90 and D 99 for each of these days and the cutoff time-the time from which the threshold cannot be reached-are shown in Table 5 .

The times to reach D 90 in the south of the UK are at least of the order of tens of minutes. The shortest time to reach D 99 in the south of the UK is 1 h 15, and at the end of March, it requires nearly 5 h of exposure to reach D 99 . So, the shortest times required to reach D 99 are at least of the order of hours, rather than tens of minutes.

The timescales for reaching D 90 and D 99 should be applicable for contaminated outdoor spaces with airborne viral load near the ground and surfaces (fomites) that are horizontal and in full view of the sky. However, consideration should be given to certain caveats. For airborne viral load, even over the shortest timescales of tens of minutes considerable dilution and dispersion would have occurred in the outdoor environment which is likely to be a significant contributing factor for reducing onward transmission (19) . In addition, Table 5 should therefore be treated with caution since they are best case scenarios.

Solar UV daily radiant exposures, in particular for the shortest UV wavelengths, were significantly higher in spring 2020 in comparison with the preceding 5 years across most of the UK, while irradiance generally appeared to be in the normal expected range of 2015-2019. The month with the greatest increases at the most locations was April, with increases in erythema effective daily radiant exposure of > 30% at all eight UK solar monitoring sites and increases in UV-A daily radiant exposure of > 20% at five sites. The significant increase in UV daily radiant exposures in spring 2020 can be explained by a higher frequency of clear days rather than increases in irradiance.

There is evidence to suggest that the higher solar UV radiant exposures in spring 2020 increased the potential for viral inactivation outdoors in April (for reaching D 90 in one day and 1 h and D 99 in one day) and May (for reaching D 90 in 1 h and D 99 in one day) when compared to the 2015-2019 values.

Assessment of the 6-year period 2015-2020 showed that a viral inactivation threshold of D 90 or greater could not be reached even with a full day of exposure to solar UV for 50-60% of the year (lowest-highest UK latitudes). D 90 in a single day was possible from April to September across the UK and not possible for most of October to March and all of November to January. D 90 in 1 h and D 99 in one day were possible at lower UK latitudes from April to September for up to around 75% of days. At higher UK latitudes, these levels of viral inactivation were possible from May to August for up to approximately 50% of days.

On days when D 90 can be reached, timescales to achieve this are highly dependent on the time of year and time of day. The shortest times to reach D 90 in the UK are of the order of tens of minutes with the latest cutoff time for reaching D 90 before the end of the day being around 15:30 UTC. The shortest times to reach D 99 in the UK are of the order of hours with the latest cutoff time for reaching D 99 before the end of the day being around 14:00 UTC. However, these times assume an ideal scenario of, for example, exposure of a horizontal surface in full view of the sky for the whole day and they should therefore be treated with caution.

Overall, these findings show that for generally at least half the year in the UK solar UV is unlikely to have a significant (at least 90% inactivation) impact on viral inactivation outdoors. These results suggest that sunlight alone cannot always be relied upon to inactivate the virus outdoors in the UK. 

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