key: cord-0998080-te15ahvw
authors: Larson, Derek; Brodniak, Sterling L; Voegtly, Logan J; Cer, Regina Z; Glang, Lindsay A; Malagon, Francisco J; Long, Kyle A; Potocki, Ronald; Smith, Darci R; Lanteri, Charlotte; Burgess, Timothy; Bishop-Lilly, Kimberly A
title: A Case of Early Re-infection with SARS-CoV-2
date: 2020-09-19
journal: Clin Infect Dis
DOI: 10.1093/cid/ciaa1436
sha: f3836fc55e57ef8ba0a92be04796f4f0a8f86a41
doc_id: 998080
cord_uid: te15ahvw

nan

A c c e p t e d M a n u s c r i p t 3 Dear Editor, It is with great interest that we read the first report of re-infection from SARS-CoV-2, which represented an important data point in the ongoing COVID-19 pandemic [1] [2] [3] . Questions have arisen regarding the timing and severity of re-infections, for which we offer a case report of symptomatic re-infection within 90 days.

42-year-old healthy male military healthcare provider presented with cough, subjective fever, and myalgias on 21 March following a workplace COVID-19 exposure and tested positive by SARS-CoV-2 RT-PCR ( Figure 1 ). Physical examination was unrevealing and supportive outpatient management was pursued [4] . Clinical resolution of illness occurred by day 10, and he returned to baseline excellent health for the following 51 days.

On 24 May he presented with fevers, cough, shortness of breath and gastrointestinal symptoms, (SNVs) were determined [5] . Global lineage was determined using a subset of SARS-CoV-2 genomes available from the Global Initiative on Sharing All Influenza Data repository (GISAID accessed, June 24, 2020). Alignments were performed [6] and a Maximum Likelihood tree was generated [7] . The SARS-CoV-2 genome from the re-infection sample was deposited in NCBI GenBank under Accession The identification of specific products, scientific instrumentation, or organization is considered an integral part of the scientific endeavor and does not constitute endorsement or implied endorsement on the part of the author, DoD, or any component agency.

This work was supported by [WUN A1417] and [GEIS P0013_20_AH_01.01] to KBL for virus isolation, sequencing, and bioinformatic analyses; and IDCRP-085 is funded by the Defense Health Program.

The authors of this study report no financial conflicts of interest.

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