key: cord-0995427-xregxgd4 authors: Manson, JoAnn E. title: Editorial from the new editor-in-chief date: 2020-09-04 journal: Contemp Clin Trials DOI: 10.1016/j.cct.2020.106127 sha: 21bc1cd362108bedec3d56325b152d28b811891d doc_id: 995427 cord_uid: xregxgd4 nan stakeholders. Articles that address methods for, and issues related to, conducting cost-efficient, pragmatic, and adaptive trials are a priority. Indeed, the current Covid-19 pandemic highlights the urgent need for an infrastructure to enable quickly deployable and efficient trials in order to achieve timely and relevant results. I would argue that such studies are critical for expeditious testing of treatments and prophylactic interventions to slow the devastation wrought not only by infectious disease pandemics but also by chronic diseases. Fortunately, a variety of innovative approaches have been proposed to make trials costefficient and pragmatic and thus more likely to reach definitive conclusions regarding an intervention's effectiveness in a timely fashion. One such approach is use of a hybrid design that combines (a) remote intervention(s) in a study population of sufficient size to allow a Nicolette van Dijk and the capable team at Elsevier, for providing invaluable support and "scaffolding" for the journal's work. Our success also relies on the authors who submit highquality work for publication consideration, the peer reviewers who deeply engage with individual submissions to ensure optimal quality and integrity of published articles, and last but not least, to you, the journal's readers, with whom I hope to start an active and fruitful dialogue. If you have suggestions as to how Contemporary Clinical Trials can better serve the clinical trials community, please e-mail me at jmanson@rics.bwh.harvard.edu. I look forward to learning from you. Together, we can take this special journal to new heights. The VITamin D and OmegA-3 TriaL (VITAL): Rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease Vitamin D supplements and prevention of cancer and cardiovascular disease Marine n-3 fatty acids and prevention of cardiovascular disease and cancer Large-scale randomized clinical trials of bioactives and nutrients in relation to human health and disease prevention -Lessons from the VITAL and COSMOS trials Dexamethasone in hospitalized patients with Covid-19 -preliminary report Effect of hydroxycloroquine in hospitalized patients with COVID-19: preliminary results from a multi-centre, randomized, controlled trial The Vitamin D for COVID-19 (VIVID) Trial: rationale and design