key: cord-0994946-lcqn2fk1
authors: Kumar, Deepak; Gupta, Prakamya; Banerjee, Dibyajyoti
title: Letter: does vitamin D have a potential role against COVID‐19?
date: 2020-05-20
journal: Aliment Pharmacol Ther
DOI: 10.1111/apt.15801
sha: 332fb0a58e93ffdce8ff131bbf100880e978ff48
doc_id: 994946
cord_uid: lcqn2fk1

nan

The role of vitamin D in COVID-19. SARS-CoV-2 binds to the ACE2 of alveolar cells and disturbs the ratio of ACE2/ ACE activity. It increases ACE activity and, in turn, results in more angiotensin II formation causing pulmonary vasoconstriction to precipitate severe COVID19. Vitamin D induces ACE2 expression, which limits the formation of angiotensin II via ACE and reduces lung injury. Besides, vitamin D also acts on renin and inhibits its activity, which further contributes to the reduction in angiotensin II. Therefore, vitamin D supplementation may have a protective role against COVID-19. 

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