key: cord-0992856-ti67nwva
authors: Ramireddy, Swetha; Gudipati, Smitha; Zervos, Marcus
title: Expect the Unexpected: A Rare Case of Pseudomonas aerguinosa Endocarditis
date: 2020-05-12
journal: IDCases
DOI: 10.1016/j.idcr.2020.e00787
sha: 6037c3896138da71715bdf83ca68de76dc7e4b79
doc_id: 992856
cord_uid: ti67nwva

Infective endocarditis (IE) caused by Pseudomonas aeruginosa is extremely uncommon. Reported cases have usually been associated with intravenous drug use, prosthetic heart valves, and/or implanted cardiac devices. Traditionally, successful treatment has necessitated a combination of antimicrobial(s) and valve replacement. Yet, P. aeruginosa IE remains difficult to manage, especially in cases where valve replacement may not be an immediate option. We present such a case of P. aeruginosa IE, highlighting that medical management with 2 antipseudomonal synergistic agents may be an alternative to surgery in particularly complicated cases.

Infective endocarditis (IE) caused by Pseudomonas aeruginosa is rarely seen in clinical practice [1] . Noted to have a high mortality rate, early diagnosis and intervention with both antibiotics and surgery are crucial in treating P. aeruginosa IE [1] [2] [3] . Although there is a rise in infection in patients with prosthetic heart valves or with implanted cardiac devices such as pacemakers or defibrillators, many of the reported cases in literature of P. aeruginosa IE involve right sided disease in intravenous drug users (IVDU) [2] [3] [4] [5] [6] [7] [8] [9] . Here, we present the rare case of native-valve left-sided P. aeruginosa endocarditis in a patient with no history of IVDU.

A 72-year-old male with a past medical history of Parkinson's disease and benign prostatic hypertrophy (BPH) requiring intermittent urethral self-catheterization presented to our facility as a transfer from an outside hospital (OSH) for cardiothoracic surgery (CTS) evaluation given persistent P. aeruginosa bacteremia and findings on transesophageal echocardiogram (TEE) of a large vegetation involving the aortic valve, consistent with a diagnosis of IE.

The patient had originally presented to the OSH approximately two months prior complaining of fever and right sided flank pain. Urinalysis was grossly positive on admission. A subsequent computerized tomography (CT) of the abdomen/pelvis revealed a 1 cm right sided calculus at the ureter-pelvic junction for which a nephrostomy tube was placed followed by percutaneous nephrolithotomy (PCNL). The patient initially received 2 days of piperacillin/tazobactam, however, once the urine culture resulted in P. aeruginosa with no significant associated resistance, the patient was discharged home on a 5-day course of ciprofloxacin 750 mg twice daily (BID) per os (P.O.). Both sets of blood cultures obtained on arrival to the emergency department at the OSH were negative for growth. Although the patient 3 J o u r n a l P r e -p r o o f did have an indwelling urinary bladder catheter placed during hospitalization, it was removed prior to discharge and he was told to resume self-catheterization at home. Two months later, the patient presented back to the OSH with fever. CT abdomen/pelvis revealed passage of the right sided calculus, however, this time, urine and blood cultures were positive for P. aeruginosa with no significant associated resistance. He was started on cefepime and a transthoracic echocardiogram (TTE) obtained on admission was negative for any valvular abnormalities, including vegetation. However, despite treatment with cefepime, the patient's blood cultures continued to be positive for P. aeruginosa that had no significant associated resistance. One week into hospitalization, a CT chest with contrast was obtained and revealed a paratracheal mass, possibly suggestive of lymphadenopathy. On day 10 at the OSH, a TEE revealed a large vegetation involving the right coronary cusp of the aortic valve with severe aortic insufficiency; it was noted that an abscess was unable to be ruled out. Based on the persistent bacteremia and TEE findings, a diagnosis of infective endocarditis was reached.

Tobramycin was added to the cefepime on day 10 to provide a synergistic antipseudomonal effect and the patient was then transferred to our facility for CTS evaluation.

A CT head and magnetic resonance imaging (MRI) of the brain done upon arrival per CTS request revealed multiple punctate hemorrhages in the parietal lobe, the largest of which was a 1.8 cm focus in the left parietal lobe. The patient had no apparent neurological deficits; however, was transferred to the Neuro-Intensive care unit for closer monitoring for approximately 24 hours. Additionally, due to the risk of hemorrhage from the heparin bolus needed during valve replacement, CTS felt it was appropriate to defer valve replacement surgery and upon their own review of the TEE, did not see an abscess. Of note, the patient was also On day 15 at our hospital, two sets of blood cultures drawn on day 10 were found to be negative for growth for 5 days. A PICC line was placed and the patient was discharged to a rehabilitation facility with the same antibiotic regimen for 6 weeks. He was seen in the Infectious Disease outpatient clinic approximately 2 weeks after discharge and stated that he felt well. The plan was to have him follow up 4 weeks later and re-draw blood cultures and discontinue antibiotics upon the first negative culture results and to repeat blood cultures again 2 weeks after that. This plan was discussed in detail with the patient. However, due to the onset of the COVID-19 pandemic, the follow up appointment has been deferred indefinitely.

Additionally, the patient decided to follow up with CTS upon discharge regarding possible valve 5 J o u r n a l P r e -p r o o f replacement. He was advised to have pre-operative screening measures done first. This has also been deferred indefinitely due to COVID-19.

We present a rare case of left-sided P. aeruginosa endocarditis in a patient with no history of IVDU, cardiac device implantation, or the presence of a prosthetic valve. Although in the past P. aeruginosa IE has been associated with intravenous drug users, recently, a shift towards nosocomial, or healthcare associated P. aeruginosa, is being observed [2] [3] [4] [5] [6] [7] [8] [9] . A large cohort study done by Morpeth et al. found that of non-HACEK gram negative IE (species other than Haemophilus species, Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella species), only 4% of the cases were associated to active IVDU [6] . Additionally, a recent Italian cohort study found that the genitourinary tract was the most frequent source of infection in IE due to gram negative bacteremia (GNB) [7] . In the case of this patient, who was found to have right sided nephrolithiasis requiring PCNL as well as a P.

aeruginosa cystitis upon initial presentation to the OSH months prior, it may be argued that the PCNL, the indwelling urinary bladder catheter placed during that admission, and/or the intermittent urethral self-catheterization the patient resumed at discharge, may have introduced bacteria into the bloodstream, possibly in the case of the latter two by damaging the urethral mucosa. No blood cultures, other than the two obtained in the emergency room on arrival that admission, were obtained until the patient presented back to the OSH 2 months later and was found to be bacteremic.

Given the high overall mortality of P. aeruginosa IE, found to be approximately 64% in left sided disease in non-IVDU according to one literature review, early diagnosis and treatment are essential for optimal outcome [2, 8] . As with all cases of endocarditis, blood cultures 6 J o u r n a l P r e -p r o o f repeatedly positive for an organism should warrant an early TEE for evidence of valvular vegetations despite an initial negative TTE [2] . Our patient was persistently bacteremic while on adequate antibiotic treatment and had a history of a recent urological procedure and complicated cystitis with the same organism. Therefore, despite a negative TTE, a TEE should not have been deferred until day 12 at the OSH. An earlier TEE may have allowed for an expeditious diagnosis and intervention from CTS prior to the intracranial hemorrhage that delayed the patients care.

Traditionally, successful treatment of left-sided IE has necessitated a combination of antibiotics and source control in the form of valve replacement. Antibiotic therapy for P.

aeruginosa IE consists of six weeks of two intravenous antipseudomonal agents, each from a different antimicrobial class to which that strain is susceptible to [2] . This combination draws on the concept of antimicrobial synergy, which allows for two different mechanisms of bacterial killing. In gram-negative infections, synergy has been traditionally seen with beta-lactam and aminoglycoside combinations; the beta-lactam mediated disturbance of the cell walls of gram negative bacteria allows aminoglycosides to pass into the periplasmic space [10] . Recently however, similar data has been emerging with beta-lactam and fluoroquinolone combinations [10] .

Although initially our patient was continued on the cefepime and tobramycin that was started at the OSH, the tobramycin was discontinued and ciprofloxacin was started in its place on day 8 due to worsening renal function. Additionally, due to a higher MIC for cefepime that resulted on day 10 for cultures that were obtained on day 7, (MIC of 8 compared to that of 2 from blood cultures obtained on arrival) the cefepime was switched to an extended infusion rate, 2g every 8 hours administered over 3 hours, instead of over 3-5 minutes. This change is based on the pharmacodynamics principle that beta lactam antibiotics have a time dependent effect on 7 J o u r n a l P r e -p r o o f bacterial eradication [11, 12] . Therefore, increasing the duration of exposure of the antibiotic to the bacteria by extending the infusion rate may be more effective at bacteria eradication especially at higher MICs [11, 12] .

This case highlights that medical management with 2 antipseudomonal synergistic agents may be an effective alternative to surgery in particularly complicated situations. In the case of our patient surgery was delayed at the time due to a guarded clinical and functional status as well as the presence of hemorrhagic foci in the parietal lobes as evident on imaging. More recently, the COVID-19 pandemic has diminished the patient's ability to adhere to follow up measures or consult with CTS. In the meantime, the patient has been advised to continue with the regimen of ciprofloxacin 750 mg BID P.O. and extended infusion cefepime. We have good reason to remain hopeful that updated blood cultures will be negative when the patient is in fact able to follow up.

Author Statement Swetha Ramireddy: Writing -original draft preparation and subsequent review and editing Smitha Gudipati: Writing -review and editing Marcus Zervos: Supervision 

An invasive case of left-sided endocarditis caused by Pseudomonas aeruginosa in a patient with history of intravenous drug abuse

Left-sided Pseudomonas aeruginosa endocarditis in patients without injection drug use

Pseudomonas aeruginosa infective endocarditis in patients who do not use intravenous drugs: Analysis of risk factors and treatment outcomes

Pseudomonas endocarditis in the

Infective endocarditis caused by gram-negative bacteria: a review of the literature

Non-HACEK gram-negative bacillus endocarditis

Risk factors and outcomes of endocarditis due to non-HACEK gram-negative bacilli: data from the prospective multicenter Italian endocarditis study cohort

Non-nosocomial healthcare-associated leftsided Pseudomonas aeruginosa endocarditis: a case report and literature review

Prosthetic valve endocarditis caused by Pseudomonas aeruginosa with variable antibacterial resistance profiles: a diagnostic challenge

Combination therapy for treatment of infections with gram-negative bacteria

Extended-infusion cefepime reduces mortality in patients with Pseudomonas aeruginosa infections

Prolonging β-lactam infusion: a review of the rationale and evidence, and guidance for implementation

We would like to thank and acknowledge all the healthcare workers that helped take care of this patient.J o u r n a l P r e -p r o o f