key: cord-0992353-n6jgsvhl
authors: Elhag, Shahad Abobakr; Ibrahim, Halah; Abdelhadi, Shaden
title: “Angioedema and urticaria in a COVID-19 patient: a case report and review of the literature”
date: 2020-08-05
journal: JAAD Case Rep
DOI: 10.1016/j.jdcr.2020.07.042
sha: de0aa24d1eb83f4fbe25a7a45b09ea5be736e8d7
doc_id: 992353
cord_uid: n6jgsvhl

nan

As SARS-CoV-2 spreads worldwide, non-respiratory manifestations of COVID-19 are being 46 reported with greater frequency. A variety of dermatologic eruptions associated with this viral 47 infection have been recognized. Although urticaria has been reported several times in association 48 with COVID-19, angioedema has rarely been reported. We present a case of angioedema and A 40 year old previously healthy male presented to the emergency department with a 1 day 68 history of lip and bilateral eyelid swelling and a generalized pruritic rash, all starting 69 simultaneously. The patient described the lesions as migratory, each lasting for a few hours. The 70 rash started on the back and subsequently spread to his extremities within hours, sparing his face 71 and scalp. The eyelid swelling decreased on the same day without treatment while the lip 72 swelling persisted. Clinically, there was no clear association with ingestion of any food or 73 medication. He denied recent ingestion of newly prescribed or over the counter medications, 74 herbal supplements or home remedies. He denied similar previous presentations or history of 75 allergies, except for an episode of generalized rash after taking an antibiotic 4 years prior to 76 presentation. The patient has no medical conditions and denied being on any medications, 77

including angiotensin converting enzyme-2 inhibitors (ACE2 inhibitors). 78 79 Prior to the above symptoms, he had a 5 day history of mild, non-productive cough and dyspnea 80 with low-grade fever. He reported taking 2 grams (4 tablets) of acetaminophen for the fever 81 within 2 days prior to his presentation, but with no improvement. Of note, he has regularly taken 82 acetaminophen in the past without any rashes or adverse reactions. He did not report a history of 83 smoking or alcohol consumption and also denied family history of allergies or angioedema. The 

Classification of the cutaneous 196 manifestations of COVID 19: a rapid prospective nationwide consensus study in Spain 197 with 375 cases

Urticaria and infections

Cutaneous manifestations in COVID 19: a first perspective

COVID 19) infection: a case report in Tangerang

Urticarial exanthem as early diagnostic clue for 207 COVID 19 infection

Angioedema in COVID 210 19

Acute urticaria with 212 angioedema in the setting of coronavirus disease 2019

Urticaria and angioedema as a prodromal cutaneous manifestation of SARS

Angioedema in a Patient with COVID 19

In silico studies on the comparative characterization of the 221 interactions of SARS-CoV-2 spike glycoprotein with ACE-2 receptor homologs and 222 human TLRs

Evidence for bradykinin release in chronic spontaneous urticaria

Kallikrein-kinin blockade in 227 patients with COVID 19 to prevent acute respiratory distress syndrome