key: cord-0992305-1b278jcm authors: Bandyopadhyay, S.; Baticulon, R. E.; Kadhum, M.; Alser, M.; Ojuka, D. K.; Badereddin, Y.; Kamath, A.; Parepalli, S. A.; Brown, G.; Iharchane, S.; Gandino, S.; Markovic-Obiago, Z.; Scott, S.; Manirambona, E.; Machhada, A.; Aggarwal, A.; Benazaize, L.; Ibrahim, M.; Kim, D.; Tol, I.; Taylor, E. H.; Knighton, A.; Bbaale, D.; Jasim, D.; Alghoul, H.; Reddy, H.; Abuelgasim, H.; Sigler, A.; Saini, K.; Abuelgasim, L.; Moran-Romero, M.; Kumarendran, M.; Jamie, N. A.; Ali, O.; Sudarshan, R.; Dean, R.; Kisyova, R.; Kelzang, S.; Roche, S.; Ahsan, T.; Mohamed, Y.; Dube, A. M.; Gwini, G. P.; Gwokyala, R.; Br, title: Infection and mortality of healthcare workers worldwide from COVID-19: a scoping review date: 2020-06-05 journal: nan DOI: 10.1101/2020.06.04.20119594 sha: b0cf00864f81547a56aa3175db98d0e554d7dfc0 doc_id: 992305 cord_uid: 1b278jcm Objectives To estimate COVID-19 infections and deaths in healthcare workers (HCWs) from a global perspective. Design Scoping review. Methods Two parallel searches of academic bibliographic databases and grey literature were undertaken. Governments were also contacted for further information where possible. Due to the time-sensitive nature of the review and the need to report the most up-to-date information for an ever-evolving situation, there were no restrictions on language, information sources utilised, publication status, and types of sources of evidence. The AACODS checklist was used to appraise each source of evidence. Outcome measures Publication characteristics, country-specific data points, COVID-19 specific data, demographics of affected HCWs, and public health measures employed Results A total of 152,888 infections and 1413 deaths were reported. Infections were mainly in women (71.6%) and nurses (38.6%), but deaths were mainly in men (70.8%) and doctors (51.4%). Limited data suggested that general practitioners and mental health nurses were the highest risk specialities for deaths. There were 37.17 deaths reported per 100 infections for healthcare workers aged over 70. Europe had the highest absolute numbers of reported infections (119628) and deaths (712), but the Eastern Mediterranean region had the highest number of reported deaths per 100 infections (5.7). Conclusions HCW COVID-19 infections and deaths follow that of the general world population. The reasons for gender and speciality differences require further exploration, as do the low rates reported from Africa and India. Although physicians working in certain specialities may be considered high-risk due to exposure to oronasal secretions, the risk to other specialities must not be underestimated. Elderly HCWs may require assigning to less risky settings such as telemedicine, or administrative positions. Our pragmatic approach provides general trends, and highlights the need for universal guidelines for testing and reporting of infections in HCWs. From a cluster of patients with pneumonia linked to a wet market in Wuhan, China in late December 2019, the coronavirus disease (COVID-19) has rapidly evolved into a full-blown pandemic (1, 2) . At the time of writing (23 rd May), over five million people have been infected across 213 countries and territories, leading to more than 300,000 deaths worldwide (3) . On the frontlines of this global crisis are healthcare workers (HCWs) with the substantial task of diagnosing and treating an exponentially growing number of acutely ill patients, often having to make critical decisions under physical and psychological pressure (4) (5) (6) . The World Health Organization (WHO) defines health workers as "all people engaged in actions whose primary intent is to enhance health" (7) . This encompasses doctors, nurses, midwives, paramedical staff, hospital administrators and support staff, and community workers, all of whom now face the occupational risk of becoming infected with COVID-19, and at worst, even death. In one of the first cohorts of COVID-19 patients from Wuhan, 40/138 (29%) were medical staff (8) . A later study documented 1,716 infected HCWs among 44,672 confirmed cases in China, with the number rising to over 3,300 in early March (9, 10) . In the United States, as high as 19% of patients had been identified as HCWs (11) . These figures are reminiscent of the 2002 to 2004 severe acute respiratory syndrome (SARS) outbreak, in which 11 to 57% of total cases in affected countries were HCWs, equivalent to one in five patients overall (12) . Onward transmission of SARS occurred mainly through HCWs and within the healthcare setting, emphasizing the need for appropriate personal protective equipment (PPE) and adherence to infection control principles in the containment and eradication of emerging diseases (12) (13) (14) (15) (16) . Ensuring the protection of HCWs is a crucial element of any country's strategic response to the COVID-19 crisis, especially as governments rush to increase healthcare capacity to cope with the surge of patients requiring urgent care. The WHO has issued recommendations on the rational use of PPE in hospital and community settings (17) . Several colleges and speciality societies have formulated algorithms and guidelines to decrease the risk of COVID-19 transmission in their fields of practice (18) (19) (20) (21) (22) . Nevertheless, protecting HCWs remains a challenge for most countries, where shortages of adequate PPE is a daily concern. Limited testing capacity precludes early identification and isolation of cases, leading to unnecessary occupational exposure for HCWs, particularly since a high number of COVID-19 patients remain asymptomatic. In a vicious cycle, shortages of HCWs may compel staff to continue working for days on end, even under fatigue or when symptoms manifest, further increasing the risk of transmission. There are no studies that examine COVID-19 infection and death amongst HCWs globally. The aim of this scoping review was to, therefore, estimate the number of COVID-19 infections and deaths in HCWs in every country in the world, with further demographical analyses where data was available. A scoping review on the number and proportion of HCWs who have been infected with or died from COVID-19 was conducted as per the published and registered protocol (27) (Appendix S1). The primary outcomes of interest were COVID-19 infections and deaths in HCWs worldwide. Subgroup analyses were performed according to WHO region, country, and demographic characteristics. Frameworks published by Arksey and O'Malley (28) , Levac et al. (29) , and Joana Briggs Institute (30) were used to guide the scoping review. The Preferred Reporting Items for Systemic Review and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines (31) were used to report the findings (Appendix S2). Due to the time-sensitive nature of the review and the need to report the most up-to-date information for an ever-evolving situation, there were no restrictions on language, information sources utilised, publication status, and types of sources of evidence. Prior to the commencement of this study, all reviewers attended an online training and support session to ensure an accurate and standardised approach to the overall methodological process. Ongoing research support was provided for all collaborators throughout the process. Two parallel searches of academic bibliographic databases and grey literature were undertaken. 1. Bibliographic search: The search protocol for this scoping review was executed in MEDLINE and EMBASE, covering the period between the first reported case in the world on 17 th November 2019 to 8 th May 2020. The search strategy used variants and combinations of search terms related to HCWs and COVID-19 (Appendix S3). The retrieved studies were exported, and duplicate articles were discarded. Two reviewers independently screened the titles and abstracts based on the pre-defined inclusion and exclusion criteria (Appendix S1). The full texts of the remaining articles were retrieved and screened by two reviewers independently. Any disagreements were resolved by a third reviewer. The reference lists of all included articles were scrutinised to locate additional relevant publications not identified during the database searches. The reviewers also consulted with senior HCWs -identified and approached through the network of the Oxford University Global Surgery Group -across the world to identify additional publications. 2. Grey literature search: A grey literature search was performed to include sources dedicated to COVID-19 or world data. These sources included government websites, non-governmental websites, social media sites, media websites, and preprints on medRxiv (32) . Snowball searching using a web-based search engine (Google) was utilised to find additional documents and online sources. A pragmatic approach was taken for the grey literature search and a stepwise guide was provided to all data collectors to ensure consistency of search strategy. A full record of the conducted search is provided in Appendix S4. The reference list of all included documents identified through the grey literature search was examined to identify any further relevant documents and online sources missed through the above search strategy, until a saturation point was reached where no new sources were identified. All searches were completed in duplicate by two reviewers independently. A third reviewer validated these searches and resolved any disparities when they arose. Lastly, governments were contacted for further information where possible. The initial search was completed for 22/04/2020. The search was then updated for 08/05/2020 for primary and secondary outcomes. A data extraction form (Appendix S5) was developed to collect the information necessary for data synthesis. This form was piloted by the team before its use. Data extraction was completed in duplicate by two reviewers independently. A third reviewer validated the data extracted and resolved any disagreements. Several data points were extracted, including publication characteristics, country-specific data points, COVID-19 specific data, demographics of affected HCWs and public health measures employed (Table 1) . Due to the heterogeneity of the various sources of evidence used in this scoping review, each source of evidence was critically appraised. Two reviewers independently classified the quality of each included document using the AACODS checklist (Appendix S6). Any uncertainty regarding the quality of an included document was resolved through discussion among the reviewers. Mortality and infection numbers have been pooled. HCW infection and deaths due to COVID-19 as a proportion of total population infections and deaths respectively due to COVID-19 have been calculated. HCW deaths due . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint to COVID-19 as a proportion of all HCW COVID-19 infections have also been calculated and expressed as a case fatality rate (CFR): number of reported deaths per 100 cases of reported infections. Patient and public involvement was not appropriate for this scoping review. Searches were conducted up to 08/05/2020. The searches yielded a total of 976 potentially relevant citations. After data validation and cleansing, duplicated and irrelevant citations were removed manually. At this point, 594 citations met the eligibility criteria based on our protocol (See PRISMA Diagram Figure 1 ). More specifically for the bibliographic database search a total of 64 articles were retrieved. Ten duplicates were detected, thus 54 studies remained. After the screening of titles and abstracts based on inclusion and exclusion criteria, 15 of these progressed to full-text screening and eight studies were included in the final analysis. The grey literature search yielded 912 citations. After screening for inclusion and eligibility, 586 citations remained and were included in the study. Characteristics of the included sources are described in Table 2 . Overall, 594 records were included, of which 14 were journal articles. Of the remaining records, 19.5% (n=116) were government documents, 16.5% (n=98) were government websites, 48.3% (n=287) were media articles, 9.6% (n=57) were research or academic reports, . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint 3% (n=18) were statistical websites, and 0.7% (n=4) were primary sources. All sources were appraised per the ACCODS checklist, as shown in appendix S4. Primary outcomes were available for 85.1% of all countries (166/195). . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint As of 08/05/2020, a total of 152,888 HCWs had been reported to have been infected with COVID-19 ( Figure 1 ). This was 3.9% of the total number of 3,912,156 patients with COVID-19 worldwide (table 6). A total of 130 countries reported at least one case of HCW infection with COVID-19 ( Figure 1 and Appendix S7). . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint The total number of reported HCW deaths as of 8th May 2020 was 1413 ( Figure 2 ). This was 0.5% of the total number of 270, 426 COVID-19 deaths worldwide. This also suggests that for every hundred HCWs that got infected, one died. As of 8th May 2020, 67 countries had reported HCW deaths related to COVID-19 ( Figure 2 and Appendix S7). China and Italy were the first two countries to report HCW deaths, and the first deaths in each of these countries occurred over a month apart (Appendix S8). . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint Although most countries released the total number of HCW deaths or infections, most published reports did not include details on the age category, ethnicity, or role of workers. The data below is based on a smaller number of countries that made this data available. The overall median age of the reported HCWs who were infected was 47.3 years (range: 18-84), 71.6% of whom were women. The overall median age of the HCWs who died was 56. 1 4 1 3 r e p o r t e d d e a t h s 0 8 / 0 5 / 2 0 2 0 . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint them women. The CFR for men and women were 9.47 and 1.55, respectively. Nurses were the largest HCW group with COVID-19 infection (38.6% of those infected). However, doctors were the largest group of HCWs who died (51.4%). Ethnicity data for deaths were available for Australia, France, and the United Kingdom (UK) and showed 73 deaths in white HCWs and 106 deaths in non-white HCWs. Ethnicity data for infections were only available from the United States of America (USA) and showed 2743 infections in white HCWs and 1058 in non-white HCWs. Table 4 ).The majority of deaths were also reported in the 50-59 age range, with the lowest number reported in the 18-29 age group. is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. General practitioners (GPs) appear to be the largest group of doctors who died while mental health nurses constituted the largest group of nurse subspecialists who lost their lives to COVID-19 (Table 5 ). There were 30 reported deaths in the UK amongst doctors, one third of which were GPs. is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. The highest number of COVID-19 infections of HCWs were reported in Europe (119628, 78.2%), whilst the lowest number was reported in Africa (1472, 1.0%) ( Figure 3 ). The same regional pattern was observed regarding deaths: Europe reported the highest number of deaths (712, 50.4%) and Africa the lowest (17, 1.2%) ( Figure 3 ). Although the highest number of deaths were reported in Europe, the number of infections was also so large that Europe was the region reporting the lowest CFR. The highest CFR is seen in the Eastern Mediterranean region (5.7 deaths per 100 infections), followed by South East Asia (3.1 deaths per 100 infections) ( Table 6 ). is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint On 08/05/2020, Spain reported the highest cumulative number of COVID-19 infections in HCWs in the world at 30663 (20% of all HCW infections). This is followed closely by Italy (23718) and the Netherlands (13884). Italy reported the highest cumulative number of deaths in HCWs due to COVID-19 at 220 (Figure 4) . At least 10% of all COVID-19 deaths were healthcare workers deaths in 5 countries: Guyana, Venezuela, Afghanistan, Costa Rica, and Kazakhstan. Full numbers and CFRs for all countries can be found in Appendix S7 & S8. The COVID-19 infection peak varies from country to country with China and Italy demonstrating some of the earliest peaks. HCW infections and deaths reflect this as can be seen in Appendix S8. Some countries are only at the early stages of COVID-19 infection. . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. Here we present the first scoping review to date examining the number of COVID-19 infections and deaths among HCWs across 195 countries. We conducted this search to estimate the infection and mortality burden among all individuals involved in the care of COVID-19 patients -from diagnosis to treatment and rehabilitation. In addition, we hoped to identify any factors associated with the risk of infection and death in HCWs. There is an important need to address the incidence of COVID-19 related illness in HCWs globally. Failure to address infection and mortality amongst HCWs has the potential to further increase transmission of COVID-19 within healthcare facilities and their wider communities (33,34). The resulting shortage of HCWs may impair the quality of the provision of health services nationally both during the acute phase of the pandemic, and in the long term. Occupational risks in the workplace must be minimised if not altogether eliminated. Moreover, a clear pathway must be present for the early diagnosis and treatment of HCWs suspected to have contracted COVID-19. It is essential that measures are put in place to ensure that HCWs are continually protected. A total of 152,888 infections and 1413 deaths were reported. Our results revealed a number of trends. The overall infection and death trends followed that of the general world population COVID-19 infection trends. Infections were mainly in women, but deaths were mainly in men. Infections were seen more in nurses, deaths more in doctors. Within the data available, GPs were the highest risk speciality for deaths amongst doctors, while the highest risk nursing speciality was mental health. It is possible that there was less PPE available in the community, with confirmed cases in hospital wards being prioritised, or that the high flow of patients through . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint GP services has led to an increased risk of viral transmission. It may just reflect the higher number of GPs compared to hospital doctors. Mental health specialists may also be lacking PPE. Many mental health nurses also work in the community and often work in close proximity to patients, which may increase their risk of exposure. The majority of infections and deaths were reported in the 50-59 year age range, while the group aged over 70 years had the highest CFR. Europe had the highest number of infections and deaths, but the lowest CFR, while the Eastern Mediterranean had the highest CFR. By population, regions such as the Indian subcontinent and Africa reported relatively low numbers of HCW infection and death. These trends must be considered in the context of the paucity of data, and the natural history of the disease. The differing COVID-19 infection curves in different countries is evident in the reporting trends; some countries are at the beginning of the HCW infection peak, while some are beyond. The first reported case of COVID-19 in Africa was nearly a month after the first case in Europe and Africa is slightly behind Europe in its disease course; their lower reported numbers of HCW infection is therefore unsurprising, as they are also reporting lower rates of infection overall. If this continues as the epidemic in Africa progresses, it will be necessary to consider what lessons can be learnt. Furthermore, reporting varies significantly between countries. The USA, one of the countries most severely affected by the pandemic, has not reported data about this topic for over one month. While other countries, such as the Philippines provide daily updates. The availability and quality of testing and guidelines for COVID-19 testing varies greatly across countries, which further limits the reliability of the observed trends. Estimating the percentages of HCWs infected by COVID-19 is crucial for adjusting infection prevention policies applied in the healthcare system to reduce viral transmission. The primary limitation of this scoping review was the quality of the data available to us. A wide range of data was used, including grey literature, which made it difficult to normalise datasets. Furthermore, different countries were at different stages of their epidemics when we collected data. Given the incubation period of the virus before symptoms are seen and the lag in initial infection and death for those who succumb to COVID-19, data between countries at different stages of their epidemics will not be comparable. To make data comparable between different countries we would have needed to batch them according to when their epidemics started, but clear information about this was unavailable. As countries move past the peak of the virus and life begins to move back to normality, increased availability of high-quality data should allow us to conduct more extensive quantitative analysis of HCW infections. A retrospective analysis would allow countries to be matched at the same stage of the pandemic -thus allowing a like-for-like comparison. For our primary analyses, a key limitation was the heterogeneity in HCW classification. Differences here made it difficult to accurately compare data between the countries because, for example, some countries may include all allied healthcare professionals in their numbers, others may not, which could result in reporting inaccurate proportions of HCWs infected by COVID-19. Additionally, there was limited access to accurate data about confounding variables, such as availability of testing for COVID-19 in different countries, which could have influenced infection and mortality rates among healthcare workers. Due to lack of testing, many cases of COVID-19 are diagnosed as 'atypical pneumonia' in some countries and thus do not feature in published figures for COVID-19 cases or deaths. Given the lack of robust data across different variables, including confounding factors, it was not possible to establish causative or even correlative links between the different variables collected and we were, therefore, limited to descriptive analyses. Infection control training must be provided for those working on the frontlines of the COVID-19 outbreak response, especially among redeployed HCWs with little experience in the clinical management of infectious diseases (35) . Regulative and supportive measures must be put into place to ensure compliance with infection control policies in the workplace at all times. . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint The first step to achieve this would involve appropriate measures for identifying and registering those who have been infected as early as possible. Our study clearly highlights the lack of universal access to early identification measures and infection registration processes across healthcare systems in the world. The testing guidelines, access and reporting systems vary hugely across countries and are not merely a reflection of country level healthcare expenditure, although this is an important factor and further highlights inequalities between HICs and LMICs. The unavailability of relevant data in a timely manner, (which was seen in both HICs and LMICs) makes it difficult to estimate the true burden of infection and effectively plan management strategies. It also inhibits any attempt to learn from those countries beyond their peak and plan timely preventative measures in those who are yet to experience the peak. We highly recommend universal guidelines to be in place for testing and reporting of infections in HCWs in a timely manner, with consideration towards a healthcare worker international infection registry. The gender related difference in infection and death rates in HCWs is one that has not been reported previously. Many factors may contribute towards this including more nursing staff being female and more doctors being male which may reflect differences in exposure levels, training and equipment provided, age at qualification. Further investigation of the identified trends would be recommended. Although physicians working in certain specialities may be considered high-risk due to frequent exposure to oronasal secretions (e.g. otolaryngology, anaesthesiology, dentistry (36)), the risk to other specialities who work in other health care settings, including clinics and mental health facilities, must not be underestimated. The high rate of morbidity and mortality in elderly HCWs may require assigning them to less risky settings such as telemedicine, non-COVID-19 outpatient clinics, or administrative positions (37) . HCWs who report possible symptoms and those who have had unprotected exposure to COVID-19 patients must be prioritised for testing. HCWs must be offered flexible working hours to avoid overwork, and psychological intervention plans must be implemented to help HCWs in coping with physical and psychological stress (38) . Despite its limitations, our analyses do provide a broad coverage of the data available across the world and the data we used for our analyses were run through the AACODS checklist to ensure an acceptable standard across all datasets was maintained so that we could compare them. The descriptive analyses also importantly point to the lack of reliable data in so many countries due to lack of infrastructure to quickly and robustly capture data on healthcare workers and other aspects of healthcare systems that could affect COVID-19 related morbidity and mortality among them. The countries whose datasets met the AACODS checklist criteria could serve as examples and provide best practice for countries lacking robust data collection policies and data collection systems. Our pragmatic approach in this study provides general trends to provide rapid information in response to widespread urgent calls from healthcare workers worldwide. All authors declare no competing interests. This research has received no specific grant from any funding agency in public, commercial or not-for-profit sectors. . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint RK is the guarantor. RK and SB conceived the project. SB, RK, and AJ contributed equally to the design of the project. All authors contributed to the collection of the data. SB, REB, MA, DO, YB, AK, SAP, GB, DK, SC, MK, AJ, AM and RK drafted the manuscript. All remaining authors extensively reviewed the manuscript. All authors have approved the final manuscript and are willing to take responsibility for appropriate portions of the content. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted. (2) to identify factors that could be linked to levels of infection and mortality of health care workers between countries. A full systematic search of bibliographic databases will be performed -Embase and MEDLINE. All databases will be searched from 17 th November 2019 to 22 nd April 2020 without language restriction for all terms related to health care workers and COVID-19 (Appendix S1). The search results will be merged, and duplicate citations will be discarded. Titles and abstracts will be screened by two reviewers independently based on the pre-defined inclusion and exclusion criteria. The full text of the remaining articles will be retrieved and screened by two reviewers independently. Conflicts are to be resolved by mutual agreement or by a third reviewer. The reference lists of included documents will be examined to identify any further relevant documents missed through the above search strategy. A grey literature search of WHO documents, government documents, and non-governmental organisation documents will also be conducted. Social media sites, media websites, and google will be utilised to find these documents and cross-reference sources. All documents will be collected by two reviewers independently. The reference lists of included documents will be examined to identify any further relevant documents missed through the above search strategy. The inclusion of the documents and data extracted from them will be compared between the two reviewers and validated by a third reviewer. The search strategy outlined above will be performed by individuals who have experience in research methodologies. All reviewers will attend an online training and support session delivered by SB and RK before performing any searches. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) guidelines will be used to write and report the findings Inclusion Criteria: All studies, synopses of studies, synthesis, synopses of synthesis, and summaries are eligible to be included. Primary data -where available -will be eligible for inclusion Studies will be excluded if they do not use real human data or do not state their methodology. The infection and mortality of health care workers associated with COVID-19 in all country settings. For the purposes of this review, a country is that which is recognised by the United Nations (UN) to be a sovereign country. Inclusion: • Health care workers. For the purposes of this review, a health care worker is one who delivers care and services to the sick and ailing either directly as paramedics, nurses and doctors, or indirectly as aides, helpers, laboratory technicians, and medical waste handlers. Exclusion: • Animal studies • Statistical modelling . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint This review includes settings at all levels of development. It considers low-, middle-, and high-sociodemographic index (SDI) countries There is no restriction on time to mortality outcome Factors that could be linked to infection and mortality of health care workers with COVID-19 Using a pre-designed and pre-piloted data extraction form, data from each included document will be collected by two independent reviewers. Conflicts in data collection will be resolved by a third reviewer. From all included documents information will be extracted on study design, study setting, study population, participant demographics, timeframe of the study, date of publication, public health measures implemented, health care worker infected with COVID-19, health care worker mortality related to COVID-19, and information for assessment of the risk of bias. Two reviewers will independently classify the risk of bias in each included document using the risk of bias in randomised trials 2 (ROB 2) tool, risk of bias in non-randomised studies (ROBINS I) tool, assessing the methodological quality of systematic reviews (AMSTAR) tool, and AACODS checklist as appropriate. Documents will be graded as high (bias is very likely due to essential errors), moderate (no essential deficiencies, but not all criteria are met), low (bias is unlikely), or unclear. The reviewers will discuss and resolve any disagreements with the level of bias in a study. . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint A random effects model will be used to pool mortality and infection rates. Where possible, associations will be analysed by computing and/or pooling this estimation using a random effects meta-analysis. Health care workforce deaths due to COVID-19 as a proportion of total population deaths due to COVID-19 will be calculated. Health care workforce deaths due to COVID-19 as a proportion of all health care work force COVID-19 infections and health care workforce deaths due to COVID-19 as a proportion of the total healthcare workforce will be calculated and compared to publicly available total population data. Prevalence and risk ratios will be given. Where possible, subgroup analysis will be by region (by world bank), SDI status (low SDI country, middle SDI country, and high SDI country), age range (18-29; 30-39; 40-49; 50-59; 60-70) , gender (male/female), ethnicity, type of healthcare worker, sub-specialities, and level of training. Describe the rationale for the review in the context of what is already known. Explain why the review questions/objectives lend themselves to a scoping review approach. 3 Objectives 4 Provide an explicit statement of the questions and objectives being addressed with reference to their key elements (e.g., population or participants, concepts, and context) or other relevant key elements used to conceptualize the review questions and/or objectives. Indicate whether a review protocol exists; state if and where it can be accessed (e.g., a Web address); and if available, provide registration information, including the registration number. Specify characteristics of the sources of evidence used as eligibility criteria (e.g., years considered, language, and publication status), and provide a rationale. Information sources* 7 Describe all information sources in the search (e.g., databases with dates of coverage and contact with authors to identify additional sources), as well as the date the most recent search was executed. Search 8 Present the full electronic search strategy for at least 1 database, including any limits used, such that it could be repeated. 4 Selection of sources of evidence † 9 State the process for selecting sources of evidence (i.e., screening and eligibility) included in the scoping review. 5 Data charting process ‡ 10 Describe the methods of charting data from the included sources of evidence (e.g., calibrated forms or forms that have been tested by the team before their use, and whether data charting was done independently or in duplicate) and 5 . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. If done, provide a rationale for conducting a critical appraisal of included sources of evidence; describe the methods used and how this information was used in any data synthesis (if appropriate). Synthesis of results 13 Describe the methods of handling and summarizing the data that were charted. 6 Give numbers of sources of evidence screened, assessed for eligibility, and included in the review, with reasons for exclusions at each stage, ideally using a flow diagram. Summarize the main results (including an overview of concepts, themes, and types of evidence available), link to the review questions and objectives, and consider the relevance to key groups. Limitations 20 Discuss the limitations of the scoping review process. 16 Provide a general interpretation of the results with respect to the review questions and objectives, as well as potential implications and/or next steps. Describe sources of funding for the included sources of evidence, as well as sources of funding for the scoping review. Describe the role of the funders of the scoping review. 17 is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint Appendix S7: Supplementary figures for the number of COVID-19 infections and deaths reported in healthcare worker per country as of 08/05/2020 . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted June 5, 2020. . https://doi.org/10.1101/2020.06.04.20119594 doi: medRxiv preprint World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19 -11 A novel coronavirus from patients with pneumonia in China World Health Organization. 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