key: cord-0992046-qruvgpr6 authors: Bakaloudi, Dimitra Rafailia; Barazzoni, Rocco; Bischoff, Stephan C.; Breda, Joao; Wickramasinghe, Kremlin; Chourdakis, Michail title: Impact of the first COVID-19 lockdown on body weight: A combined systematic review and a meta-analysis date: 2021-04-20 journal: Clin Nutr DOI: 10.1016/j.clnu.2021.04.015 sha: f0a34ca593c9a85eddeb808e5d80d93266ed43cd doc_id: 992046 cord_uid: qruvgpr6 The coronavirus disease 2019 (COVID-19) and the imposed lockdowns in order to control the pandemic, had undoubtedly influenced the lifestyle of millions of people worldwide. The period of confinement, which was characterized by seizing most business activities and allowing only for e-classes at schools and universities, leading also to a lower physical activity, could have affected eating behaviors of people of all ages. In this study we aimed to investigate the impact of the first lockdown period (March–May 2020) on body weight (BW) and on body mass index (BMI) in both adults and adolescents (>16 years old). A systematic literature search was conducted in PubMed®, Scopus®, Web of Science® and EMBASE® databases and 36 observational (35 cross-sectional and one cohort) studies were included. BW and BMI changes after/during the lockdown period were examined. BW was stated as increased in a significant part of the individuals (11.1–72.4%), although a range of 7.2–51.4% of individuals reported weight loss. A significant higher BW was observed with a weighted mean between-group difference (WMD) 1.57 (95% CI 1.01 to 2.14) in the post-lockdown period compared to the before lockdown time and higher BMI, 0.31 WMD (95% CI, 0.17 to 0.45) was identified before the lockdown period. At variance with general trends, one study in older adults (>60 years old) notably reported a significant BW loss, suggesting a higher risk for lockdown-induced weight loss and potentially malnutrition in the elderly population. Overall increments in BW are an alarming effect of lockdown during the COVID-19 pandemic, leading to potential higher incidence of overweight, obesity and related health-risks as well as other noncommunicable diseases. Further studies are needed to assess potential group-specific impacts, with particular regard to weight gain in younger people and risk of weight loss, malnutrition and sarcopenia in older adults. In December 2019 a severe acute respiratory syndrome caused by a novel coronavirus (SARS-COV-2) was first reported in Wuhan, China due to an outbreak of a severe pneumonia across the population [1] . Due to its rapid spread throughout the globe, the World Health Organization (WHO) after initially (end of January 2020) claiming this as a public health incidence of international concern, declared the coronavirus disease 2019 (COVID- 19) on March, 11th 2020 as a pandemic [2] . The absence of effective drugs or vaccine at that time, led the Governments of more than 100 countries to enforce strict measures in their efforts to limit the transmission and control the spread of the disease [3] . Such measures included physical distancing with full or partial lockdowns, schools and universities closures, as well as discontinuation of most business' activities; so as by April 2020 more than a third of the population globally was under any kind of lockdown restriction [3] . During the 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 confinement period, people were encouraged to telework and/or online learning and stay at their homes as much as possible [3] . Medical emergencies, essential work, limited physical activity and purchasing food were the main reasons for individuals to leave their homes [3] . All these crucial measures of self-isolation could have negative impact on people's life both on mental health and on lifestyle related behaviors [4e6] . Changes in daily routine, fear and anxiety of COVID-19 and absence from the work environment, school or university which are linked to boredom could lead either to binge/emotional eating [7e9], or to appetite loss [10] . Moreover, during the COVID-19 lockdown high prevalence of sleep disorders [11, 12] as well as physical inactivity [13] which are also linked to imbalanced nutritional patterns for both adults and adolescents were identified [14, 15] . In addition the dramatic increase in the food offer via online applications could potentially lead to high consumption of processed foods [16] . Some of the abovementioned changes (i.e. higher inactivity, absence from the work environment or school, etc.) have similarities with the holiday season where people are more prone to weight gain [17, 18] , and therefore we aimed to examine the impact of that confinement period on body weight (BW) and Body Mass Index (BMI). Nevertheless, little is known regarding BW changes during this health crisis worldwide (which is also combined with higher levels of anxiety and/or stress), although many observational studies have been conducted locally. According to our knowledge, this is the first combined systematic review and meta-analysis which investigates changes on BW and/or BMI of both adults and adolescents after and/or during the first COVID-19 lockdown period (MarcheMay 2020) compared to before lockdown times. This is a combined systematic review with a meta-analysis which was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) [19] (Supplementary Table 1) . A systematic electronic search was conducted on PubMed ® , Scopus ® , Web of Science ® and EMBASE ® databases (up to December, 21st 2020) using the index Medical Subject Headings (MeSH) terms "BMI", "weight change", "weight gain", "weight loss", "covid-19", "Sars-Cov-2" and the final search string was: ((BMI) OR (Weight change) OR (Weight gain) OR (weight loss)) AND (COVID-19) for PubMed ® database and was modified accordingly for other research engines (Keywords and terms used for our search strategy can be found in Supplementary File 1). All observational (prospective and retrospective cohorts, and cross-sectional) studies examining BW and BMI before and after/ during the period of lockdown and/or percentage of BW change were eligible. The population of interest was adults and adolescents !16 years old who were under lockdown restrictions due to the COVID-19, during the pre-specified period of MarcheMay 2020. Studies including data from children <16 years old, hospitalized subjects, symptomatic COVID-19 patients and individuals suffering from chronic diseases that could affect BW and/or BMI were excluded. Records retrieved throughout literature search were input in a reference database (EndNote X7 for Windows, Thomson Reuters). After the removal of duplicates, remaining studies were assessed independently by two reviewers DB and MC for eligibility. Any disagreements on study selection were solved by consensus. The process of data extraction from the included studies was independently conducted by two reviewers (DB and MC) using a previous specified excel form. All disagreements were solved by consensus. Data extracted from each study were country origin, number, age and sex of the examined population, type and the period of the survey. In addition, changes in BW were examined. Variables referred to BW changes were presented as percentages. Available data regarding BW and/or BMI before and after/during lockdown were extracted as mean ± SD and were included in our meta-analysis. Assessment of the quality of included studies was performed by the two reviewers (DB, MC) using the modified Newcastle Ottawa Scale (NOS) for cross-sectional and cohort studies [20] . A protocol for this systematic review and meta-analysis was submitted in OSF ® platform (https://osf.io/zg43y/). The main outcome of our study was to examine changes in BW and BMI after/during the period of lockdown compared to the prelockdown period. Incomplete studies or studies not written in English or Spanish language were excluded. In this study, a meta-analysis was performed for included studies which reported data regarding BW and BMI before and after/during lockdown. The random-effects in the meta-analytic model were used in order to estimate the various assessment effects in studies, due to high between-trial heterogeneity. Moreover, the inverse variance method was used to estimate weights of each study. Weighted mean between-group difference (WMD) was used because both BW and BMI outcomes were expressed by the same measurement scale (kg and kg/m 2 accordingly). Chi-squared and I 2 test were performed to assess statistical heterogeneity across studies (p-values <0.1 indicating existence of heterogeneity). I 2 <25% indicated low degree of heterogeneity, 25e50% moderate heterogeneity and >50e70% showed significant heterogeneity. Subgroup analyses were conducted for both BW change and BMI outcomes in order to separate subjects >18 years old and with obesity, respectively. Sensitivity analysis was performed and aiming to ensure robustness of results studies with NOS rating <7 were excluded. Statistical analyses were performed using the Review Manager (RevMan, version 5.4). The eligibility process of studies included can been seen in our flow diagram in Fig. 1 . Total records identified through database searching were 2720 and two more studies were identified through references searching. After removing of duplicates (n ¼ 936), 1786 studies were screened for eligibility. Irrelevant studies according to title and abstract, studies including children <16 years old and not observational studies were excluded. Finally 36 studies, in which changes on either BW or BMI were reported, were assessed as acceptable [21e56] (35 cross-sectionals and one cohort) for our combined systematic review and meta-analysis. Characteristics of the included studies (country, period of survey, sex and age of participants) are presented in Table 1 . From those studies, two studies included both adults and adolescents [35, 42] and for the remaining 34 studies the results referred only to adult population [21e34,36e41,43e56]. Results of the quality assessment of the included studies, according to the NOS scale [20] , can be found in Supplementary File 2. According to the NOS, 23 studies [24,25,27e29,31,33e40,44,45, 47e49,51,53,54,56] were classified as satisfactory quality (5e6 stars), due to their low rating in the domain of exposure and the remaining 13 studies [21e23, 26,30,32,41e43,46,50,52,55] were classified as good quality (7e8 stars). A summary of results of BW changes can be found in Table 2 . In general, a tendency towards an increase in BW was reported in the majority of studies [21e28,30e39,41e56]. The highest increase of body weight (72.4%) was stated by Ahmed et al. including a population in Iraq [21] . In several studies, subjects who reported weight gain represented more than 30% of the total study population [22e24,26e28,30e34,37e42,44e51,55]. For the rest of the 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 included studies in which weight gain was more prevalent than weight loss, the range of the percentage reporting weight gain was 12.8e29.9% [25,35,36,43,52e54,56] . Only in one study (from Italy) a significant part of the sample had weight loss after/during the lockdown period, but it has to be noted that in this all the participants were older than 60 years old [29] . The forest plot showing BW changes can be found in Fig. 2 . Across six studies [22, 39, 42, 46, 48, 50] in which mean BW before and after/during lockdown were reported, a significant higher BW was observed 1.57 WMD (95% CI 1.01 to 2.14) in the after lockdown period compared to the before lockdown time, without heterogeneity (I 2 ¼ 0%). The forest plot showing BMI changes with respect to the impact of the COVID-19 lockdown can be found in Fig. 3 . Across the four studies included in this analysis [22, 42, 46, 50] , BMI was found increased after the lockdown period, 0.31 WMD (95% CI, 0.17 to 0.45) with low heterogeneity (I 2 ¼ 0%). In order to explore the heterogeneity across the studies examined [22, 39, 42, 46, 48, 50] BW before and after/during the lockdown period a subgroup analysis was performed according to subject age (Fig. 4) . In studies in which individuals were adults (>18 years old) a tendency towards increase in BW was observed, 0.85 WMD (95% CI, À0.16 to 1.86), with low heterogeneity among studies, (I 2 ¼ 0%) but not as statistically significant as when adolescents were also included (Fig. 2) . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 YCLNU4792_proof ■ 20 April 2021 ■ 3/9 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 Furthermore, subgroup analysis was performed according to the weight status of individuals where obese people constituted a separate subgroup. Results revealed an increase of BMI in individuals of any weight, 0.30 WMD (95% CI, 0.16 to 0.45) with low heterogeneity across the studies (I 2 ¼ 0) [22, 42, 46, 50] (Fig. 5) . Regarding BMI changes one more subgroup analysis was conducted according to subject age groups, which can be found in Supplementary Fig. 1 . In the subgroup including only adults, a tendency towards increase in BMI (not statistically significant) was observed after the lockdown period 0.46 (95% CI, À0.18 to 1.10). Sensitivity analysis was performed for BW changes including only the high quality studies [22, 42, 46, 50] according to the NOS (rating >7). Results after removing the studies which were assessed as "satisfactory" [39, 48] , showed similarly statistically significant higher BW after the COVID-19 lockdown period, 1.41 WMD (95% CI, 0.41 to 2.40), with lower heterogeneity across the studies (I 2 ¼ 23%) (Fig. 6) . Since all the studies presenting BMI changes were classified as "good quality", an additional sensitivity analysis was not performed. According to our knowledge this is the first systematic review and meta-analysis which aimed to examine the impact of the COVID-19 first lockdown on BW. In total 59,711 subjects >16 years old from 32 countries around the world (Algeria, Argentina, Bahrain, Brazil, Chile, China, Croatia, Egypt, Germany, Greece, India, Iraq, Italy, Jordan, Lebanon, Libya, Lithuania, Morocco, Oman, Palestine, Poland, Qatar, Saudi Arabia, Spain, Sudan, Syria, Tunisia, Turkey, UAE, USA and Yemen) were included in our study. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 Results of our systematic review regarding BW changes, reported that a range of 11.1e72.4% of individuals asked, stated an increased in BW after/during the lockdown period. The highest increase was observed in the study from Iraq in which the majority of the participants (45.6%) were 21e30 years old [21] . Different results could be seen even in studies coming from the same country. In 3 studies from Poland results in regard to BW gain varied between 29.9 and 45.9% of the participants, whereas the percentage of participants who stated BW loss did not differ significantly (18.6e21.7%) [23, 32, 54] . The fact that sample sizes differed between those three studies could be a possible explanation for the observed range of BW gain (312 in Błaszczyk-Bę benek et al. [23] , 1769 in Drywien et al. [32] and 1097 subjects in Sidor and Rzymski [54] ). In seven studies including Spanish population, differences in results could also be observed, ranging between 12.8e44% for reported BW gain [ [35, 46] . Furthermore, in Italy a wide range of participants stated an increased in BW (19.5e49.2%) [24, 47, 53] and 16.0% stated BW decrease [24] . Variation was low in studies coming from the USA (22.0e32.9% for reported BW gain) and 15.9e19.7% for reported BW loss [31, 36, 43, 56] . The lower percentage for reported BW came from a rather small (sample size 173 subjects) study which also did not share information of survey time [56] . The characteristics of the participants studied seem to be an important parameter for the results obtained. In particular, with regard to the highest increase observed in the study from Iraq, the majority of participants (45.6%) were 21e30 years old [21] . Similarly, in the study lead by de Luis et al. [28] , including only obese subjects, more than one third (36.3%) of them stated a further increased BW during/after lockdown. This highlights that such group of the population faces a higher difficulty to control 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 their BW during a lockdown as a result of the COVID-19 pandemic. Τhe duration of lockdown at the time of the survey also seemed to affect the result of the studies. In the Italian study by Scarmozzino and Visioli [53] the survey was conducted only for one day, on April, 15th. Lockdown restrictions were implemented by the Italian government on March 9th [57] , therefore the most likely explanation of the lower percentage (19.5%) reporting a BW increase in the study of Scarmozzino and Visioli [53] [24, 47] , is that time interval between the lockdown initiation and the day of the survey was shorter. Moreover, in Spanish studies conducted between March and April an increase in BW was stated by fewer individuals (12.8e25.8%) [25, 35, 52] compared to studies conducted between end of AprileJune in which 36.3e44.0% of participants stated increase in their BW [28, 46, 55] . This could be explained, similar to the Italian studies, by the fact that the highest impact of lockdown could be seen when the population was examined at the end or after the lockdown period. Therefore, results from studies conducted later during, or shortly after the lockdown could have been more successful in capturing BW changes. Regarding results from India, a range of 31.5e40% of participants reported BW gain and 13.8e19.0% reported BW loss [27, 37, 45] . However the fact that the lockdown in India ended in May and surveys were conducted in July [45] and August [27] could have affected the accuracy of these results. Period of survey's conduction was not reported in the Indian study of Ghosal et al. [37] . Significant loss in BW was observed only in one study from Italy [29] . In particular, in this Italian study all the participants were !60 years old (mean age 74.3 ± 6.51) and 35.7% stated weight loss whereas only 11.1% of them gained BW [29] . These results could be an alarming sign of a risk of developing malnutrition in elderly [58] . Warnings regarding the risk of malnutrition in elderly in the time of COVID-19 lockdown have been published [59, 60] but further efforts are needed in this filed. Results from our meta-analysis showed that BW (Fig. 2 ) was statistically significantly higher [WMD 1.57 (95% CI 1.01 to 2.14)] after the first COVID-19 lockdown period and this result should not be disregarded. Previously published studies have demonstrated that lifestyle changes and overeating during the COVID-19 lockdown period could lead to an increase in obesity prevalence, with a proposed definition of "Covibesity" pandemic [61] . It is well known that obesity is related to several comorbidities such as type-2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), obstructive sleep-apnea and even cancer [62] . Moreover, obesity constitutes also a risk factor for COVID-19 infection [63, 64] and may be related to more severe forms of the disease compared to non-obese patients [65] . In the subgroup including only subjects !18 years old, a higher BW after the lockdown period could be observed but was not less significant in comparison to the analysis including subjects !16 years old (Figs. 2 and 4) . A possible explanation could be that adolescents and youths were more prone to gain BW during the lockdown period. The clear reasons behind this are not clear, and only assumptions can be made. One potential explanation could be that the younger population was more physically active before the lockdown, and the related inactivity might have led to a higher positive energy balance. As an alternative, younger individuals could have engaged in even less healthy eating habits during the lockdown, with higher calorie intake. Further studies are clearly needed to test these hypotheses. It may be partly surprising that BMI was statistically significantly higher after/during the lockdown period as stated in included studies (Fig. 3) . Analysis of subgroups after excluding obese subjects (from the study of Pellegrini et al. [50] ) (Fig. 5 ) did not modify this results, however in individuals <18 years old [42] (Suppl. Fig. 1 ) a tendency towards increase in BMI was observed but not statistically significant. More studies will be needed to more clearly dissect potential group-specific and overall impacts of lockdown on BMI. Our study can be characterized by several strengths. First of all, this is the first systematic review which examined the impact of lockdown on BW changes globally, with several studies and countries to be included. Moreover, all studies included were classified as satisfactory or good quality studies according to the NOS (Suppl. Table 1 ). Among the limitations of this study is that in the majority of studies the sample examined was not representative of the country's population and this could affect the accuracy of our conclusions. In addition, relatively few studies were included in our meta-analysis despite their homogeneity. Moreover, the fact that surveys were conducted online or via telephone could have an impact on the reliability of results, as obviously data on BW and height (and therefore BMI) were self-reported. Lastly, only studies in English and Spanish were included and therefore published related studies in any other language are not part in our study. The first COVID-19 lockdown affected the BW of subjects !16 years old globally. Significant portion of the participants stated that their BW was increased during lockdown, resulting in overall significant BW increments in the current meta-analysis. This overall effect is alarming due to the risk of overweight, obesity and their relevant comorbidities. Moreover, the BW loss observed in one study in older adults may be an alarming sign for lockdown-related risk of weight loss and malnutrition in older adults, and further research is required in this important population group. Awareness of the public with respect to the importance of balanced diet and physical activity in confinement situations should be enhanced [66] also considering that the risk of future lockdowns is unfortunately not absent. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 YCLNU4792_proof ■ 20 April 2021 ■ 9/9 A pneumonia outbreak associated with a new coronavirus of probable bat origin The coronavirus disease 2019 (COVID-19) pandemic COVID-19 lockdowns throughout the world Alcohol use and misuse during the COVID-19 pandemic: a potential public health crisis? 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