key: cord-0991767-q8gpc8jg
authors: Sayed, Imran A.; Hagen, Scott; Rajamanickam, Victoria; Anagnostopoulos, Petros V.; Eldridge, Marlowe; Al-Subu, Awni
title: The Use of Alveolar Dead Space Fraction to Predict Postoperative Outcomes after Pediatric Cardiac Surgery: A Retrospective Study
date: 2021-07-09
journal: Pediatr Cardiol
DOI: 10.1007/s00246-021-02674-2
sha: ca95467fb9cc2476012b1abbd02450def2ed62c5
doc_id: 991767
cord_uid: q8gpc8jg

Patients with congenital heart disease (CHD) that have surgical repair with cardiopulmonary bypass (CPB) reflect a unique population with multiple pulmonary and systemic factors that may contribute to increased alveolar dead space and low cardiac output syndrome. This study aimed to assess and compare changes in the alveolar dead space fraction (AVDSf) in the immediate postoperative period with outcomes in children with CHD who underwent repair on CPB. A single-center retrospective review study of critically ill children with CHD, younger than 18 years of age admitted to the Pediatric Intensive Care Unit (PICU) after undergoing surgical repair on CPB and received invasive mechanical ventilation for at least 24 h. One hundred and two patients were included in the study. Over the first 24 h, mean AVDSf was significantly higher in patients who had longer hospital length of stay (LOS) (> 21 days) p = 0.02, and longer duration of invasive mechanical ventilation (DMV) (> 170 h) p = 0.01. Cross-sectional analyses at 23–24 h revealed that AVDSf > 0.25 predicts mortality and DMV (p = 0.03 and P = 0.02 respectively); however, it did not predict prolonged hospital LOS. For every 0.1 increase in the AVDSf, the odds of mortality, DMV, and hospital LOS increased by 4.9 [95% CI = 1.45–16.60, p = 0.002], 2.06 [95% CI = 1.14–3.71, p = 0.01], and 1.43[95% CI = 0.84–2.45, p = 0.184], respectively. The area under the ROC curve at 23–24 h for AVDSf was 0.868 to predict mortality as an outcome. AVDSf > 0.25 at 23–24 h postoperatively was an independent predictor of mortality with sensitivity and specificity of 83% and 80%, respectively and was superior to other commonly used surrogates of cardiac output. In the immediate postoperative period of pediatric patients with CHD, high AVDSf is associated with longer hospital length of stay and duration of invasive mechanical ventilation. Increased AVDSf values at 23–24 h postoperatively is associated with mortality in patients with CHD exposed to CPB. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00246-021-02674-2.

Patients with congenital heart disease (CHD) that have surgical repair with cardiopulmonary bypass (CPB) reflect a unique population with multiple pulmonary and systemic factors that may contribute to increased ventilation-perfusion (V/Q) mismatch and low cardiac output syndrome (LCOS). Both V/Q mismatch and LCOS are associated with prolonged mechanical ventilation, ICU length of stay, hospital length of stay (LOS), and increased cost [1] [2] . Traditionally, invasive monitoring has been used to assess cardiac output and adequacy of ventilation, but invasive monitoring has the potential for substantial risks and complications [3, 4] .

In an attempt to minimize the risk of such complications, non-invasive monitoring of alveolar dead space-to-alveolar tidal volume (Vd/Vt), also known the pulmonary dead space fraction, using capnography are increasingly used to guide postoperative management of critically ill children with CHD [5] . Pulmonary dead space is the portion of inhaled air in the alveoli that does not participate in gas exchange and quantifies the magnitude of ventilation-perfusion abnormalities in the lung [5, 6] . Pulmonary dead space fraction (Vd/ Vt) can be easily measured in patients receiving mechanical ventilation using bedside volumetric capnometry and PaCO 2 values [7] . Vd/Vt has been shown in adult and pediatric populations to have significant prognostic value in acute lung injury [8] [9] [10] .

Infants and children with CHD have been shown to have abnormal Vd/Vt. Moreover, recent studies have shown that higher Vd/Vt is associated with outcomes such as duration of mechanical ventilation and hospitalization following cardiac surgery [5, 11] . However, Vd/Vt measurement requires the use of volumetric capnography and can be quite burdensome and is not routinely monitored in the intensive care unit [12] . Alveolar dead space fraction (AVDSf), which is easily estimated using standard time-based capnography and arterial blood gas analysis, can be used as a reasonable surrogate for Vd/Vt [13] . Since most mechanically ventilated children are monitored using time-based capnography, AVDSf has been more commonly used to easily and simply estimate Vd/ Vt at the bedside [2, [14] [15] [16] . AVDSf has been shown in both pediatric and adult patient populations to have an important prognostic value in acute lung injury [16, 17, 18] . However, given that increased dead space in patients with CHD has multiple etiologies and not only the result of intrapulmonary shunt or the acute lung injury in response to CPB, the use of AVDSf in intubated infants and children with CHD in the immediate postoperative period is limited [17] .

In this study we postulate that using AVDSf cut-off values may facilitate early recognition and early intervention, which could possibly help to alleviate an evolving problem. This study aimed to assess and compare AVDSf measured during the first 24 postoperative hours with outcomes in children with CHD who underwent repair on CPB. Our primary outcome was hospital mortality. Our secondary outcomes were hospital LOS greater than 21 days and duration of invasive mechanical ventilation (DMV) greater than 170 h.

This was a single-center retrospective study. The Institutional Review Board (IRB) at the University of Wisconsin, Madison approved the study protocol with a waiver of informed consent.

A retrospective chart review was conducted for all pediatric patients ≤ 18 years of age who underwent repair of CHD between January 2012 and August 2016 at the American Family Children's Hospital. We included only the patients who were repaired using CPB, intubated, with cuffed endotracheal tube, and mechanically ventilated for at least 24 h after PICU admission with an arterial catheter in place. We excluded patients placed on extracorporeal membrane oxygenation intraoperatively or those extubated within 24 postoperative hours. All patients were monitored with an end-tidal carbon dioxide (EtCO 2 ) capnostat (Capnostream CO 2 monitors, Medtronic/Covidien, Minneapolis, MN, USA) placed between the endotracheal tube and ventilator circuit. EtCO 2 values were recorded hourly as per PICU protocol in the electronic medical records (EMR).

The medical records of patients who met the inclusion criteria were reviewed. Perioperative and intraoperative data collected included demographics, diagnosis, standard hemodynamic and respiratory monitoring data, commonly used surrogates of cardiac output [arterial blood gases, serum lactate, mean arterial blood pressure (MAP), cerebral and renal regional oxygen saturations (rSO 2 ) obtained via Near-Infrared Spectroscopy (NIRS)], total CPB time, cross-clamp time, circulatory arrest time, shunt type, shunt size, ventilator settings for the first 24 h, duration of mechanical ventilation, PICU and hospital LOS, and survival rates. All the above data were obtained by abstraction from EMR, Virtual PICU Systems (VPS) database, and Society of Thoracic Surgeons (STS) database.

We obtained the partial pressure of carbon dioxide (PaCO 2 ) values from arterial blood gas measurements for the first 24 h. Corresponding EtCO 2 values were collected from the EMR. Calculation of AVDSf was performed using the following equation: AVDSf = (PaCO 2 -EtCO 2 )/PaCO 2 [19] .

Our primary outcome measure was postoperative mortality. Based on previous studies and reports, the secondary outcomes were defined as DMV > 170 h and LOS longer than 21 days.

Association of demographic and intraoperative categorical variables with primary and secondary outcomes such as hospital mortality, LOS > 21 days vs. ≤ 21 days, and DMV > 170 h vs. ≤ 170 h was analyzed using the Fisher's exact and Wilcoxon rank-sum tests as appropriate.

Calculated AVDSf was aggregated in 2-h time intervals. To assess the trend over time of AVDSf between the primary and secondary outcomes, a polynomial mixed-effect model is used. Given that shunt fraction can have significant clinical importance on AVDSf, additional subgroup analysis, based on physiology and presence of shunt, 2 ventricle physiology with no shunt, 2 ventricle physiology with intracardiac shunt, and single ventricle was performed. Finally, we also performed additional analysis with traditional bedside surrogates of cardiac input including serum lactate, pH, and changes in blood pressure using the same method as above for AVDSf.

The AVDSf was log-transformed to ensure linearity, and the time variable was considered continuous in the model. For the trend analysis of AVDSf, a mixed-effect model with a polynomial of degree 3 was chosen based on LRT (likelihood ratio test). Predicted means were generated for each time point and back transformed to represent geometric means. Contrast statement was used to access the joint distribution of main and interaction effects to determine whether the trend was significantly different. The effect of outcomes at specific time intervals was evaluated using estimate statements in the models.

Logistic regression models were fit to determine the OR for one standard deviation increase in AVDSf in predicting the primary and secondary outcomes at 23-24 h' time interval. Receiver operating characteristic (ROC) analyses were conducted to assess the optimal cut-off values for prediction. A p value < 0.05 was considered statistically significant. SAS software (version 9.4, SAS Institute, Cary, NC) was used for all statistical analyses.

Total of 315 patients underwent cardiac surgery with CBP and received invasive mechanical ventilation for at least 24 h during the 5-year study period. One hundred and two patients were included in the study (Fig. 1) . All demographic data, perioperative risk factors, invasive markers of cardiac output, and outcomes are presented in Table 1 . S1 ). Similarly, cerebral and renal rSO 2 (as a non-invasive surrogates of CO) over the first 24 h were not statistically significant with p = 0.11 and 0.2, respectively (supplementary Fig. S2 ). Demographics and basic characteristics, serum lactate, invasive MAP, and arterial pH pertaining to secondary outcomes are illustrated in Supplementary Table S1 and Supplementary Table S2 .

Over the first 24 h, mean AVDSf was significantly higher in patients who had longer hospital LOS (> 21 days) p = 0.02 and longer DMV (> 170 h) p = 0.01. Although the mean AVDSf over the first 24 h was higher in patients who did not survive to discharge, that difference was not statistically significant, p = 0.16 (Fig. 2) . Cross-sectional analyses at 23-24 h' time interval revealed that AVDSf higher than 0.25 predicts hospital mortality and DMV (p = 0.03 and P = 0.02, respectively); however, it did not predict prolonged hospital LOS (Fig. 2) . For every 0.1 (1 SD) increase in the AVDSf the odds of mortality, DMV, and hospital LOS increased by 4.9, 2.06, and 1.43, respectively (Table 2) . Subgroup analysis for AVDSf did not demonstrate a significant Fig. 1 Consort diagram of the study. CHD: congenital heart Disease, CPB: cardiopulmonary bypass, PICU: pediatric intensive care unit association with mortality (Fig. 3) , hospital LOS (Fig. 4) , or DMV (Fig. 5 ) in the patients with no shunts, residual shunts (both right-to-left and left-to-right shunts), or single ventricle physiology.

The area under the ROC curve at 23-24 h for AVDSf was 0.868 to predict mortality as an outcome, which was superior to other commonly used surrogates of CO. Only AVDSf > 0.25 at 23-24 h postoperatively was an independent predictor of hospital mortality with sensitivity and specificity of 83% and 80%, respectively (Fig. 6A) . The area under the ROC curve at 23-24 h for AVDSf to predict hospital LOS and DMV are shown in (Fig. 6B, C) . The area under the ROC curve at 23-24 h for commonly used invasive and non-invasive surrogates of CO to predict hospital LOS and DMV are shown in (Fig. 6A-C) .

In this retrospective study of critically ill children with CHD who underwent surgical repair on CPB and required mechanical ventilation > 24 h during the postoperative period, we report that AVDSf measured at bedside, in a simple non-invasive manner, may be used to predict postoperative outcomes, including DMV, hospital LOS, and mortality. These findings are similar to other previously published studies in which pulmonary dead space fraction was observed to be a predictor of hospital outcomes [5, 20] . This study further adds to the current limited data with regards to the use of AVDSf in the postoperative period after repair of CHD on CPB, as a valuable tool to predict postoperative outcomes in this high-risk patient population.

In this study, we found that higher AVDSf at 23-24 h interval is associated with hospital mortality and prolonged DMV in postoperative patients with CHD and performed better than other commonly used surrogates of CO ( Fig. 6A-C) . Our result is consistent with Yehya et al. [20] , who reported that AVDSf > 0.31 in pediatric patients diagnosed with acute respiratory distress syndrome is associated with mortality, with an area under the ROC of 0.76 (95% CI, 0.66-0.85; p < 0.001). In their retrospective study, they found that AVDSf performed better than either initial oxygenation index or PaO 2 /FiO 2 . Similarly, our findings are consistent with those of Ong et al. [11] who found that patients with high dead space following cardiac surgery, had prolonged DMV and hospital LOS.

In contrast to our results, Shakti et al. [5] reported that in patients with single ventricle who underwent stage 1 palliation, higher Vd/Vt during the first 48 postoperative hours was associated with longer DMV and hospital length of stay; however, our subgroup analysis for both patient with both intracardiac shunts and single ventricle physiology populations did not demonstrate a significant association between elevated AVDSf and mortality, hospital LOS, or DMV. This could be explained by the fact that mechanisms behind increased dead space in patients with single ventricle patients during the postoperative period are multiple and not only the result of the inflammatory response to CPB, LCOS, or microvascular thrombosis, but could be secondary to decreased pulmonary blood flow associated with shunts placement or alveolar overdistention secondary to the use of higher tidal volumes in this population [21] . It is important to understand that the presence of shunt increases not only the alveolar-arterial O 2 difference but also the arterial-alveolar CO 2 difference and, therefore, increases calculated physiological dead space [22] . It is established that a shunt-mediated contribution to the alveolar dead space calculation would be increased by either a decrease in cardiac output or increase in metabolic rate, where either change would increase the mixed venous PCO 2 ; however, a presence of large shunt is required to achieve such results. It should also be noted that in the presence of a right-to-left shunt the Enghoff modification of the Bohr equation overestimates physiological dead space due to venous admixture [23, 24] .

Our study results were consistent with the above findings, since AVDSf in our study failed to perform as well, in patient sub-groups with residual shunts and single ventricle physiology (Figs. 3, 4, 5) . On contrary, despite some of these limitations, several recent studies from Shostak et al. [17] , Koth et al. [25] , and Shakti et al. [6] have demonstrated the effective role of elevation of AVDSf on poor postoperative outcomes, including prolonged mechanical ventilation and longer ICU length of stay specifically in the immediate postoperative period. All these studies were largely comprised with patients having an underlying shunt physiology and/ or single ventricle physiology patients. These studies did recognize the likelihood of overestimating Vd/Vt in patients with single ventricle and those with residual shunt physiology, similarly the lack of exact etiology for elevation of dead space or shunt fraction calculation is also a limitation of our study.

To have a more detailed pictures, we also report the correlation between the primary outcomes and some surrogates of cardiac output. We found that patients who had higher lactate levels, lower pH, and lower renal rSO 2 had longer hospital LOS, and patients who had lower pH had longer DMV. However, none of these surrogates had any impact on the patient's outcomes with regard to our primary outcome (mortality). This report has significant limitations. First, it's a single-center, retrospective study. Second, the findings highlighted in this study might not be generalizable to other institutions or patient populations and therefore, should be validated in adequately powered prospective studies. Third, the calculation of the AVDSf may have been affected by the retrospective data collection of the EtCO 2 values, which were not charted concurrently with the PaCO 2 values at times. Finally, our study was not able to determine the exact underlying etiology for elevation of alveolar dead space fractions.

Although our findings cannot support any conclusions regarding postoperative management of critically ill children after cardiac surgery, it emphasizes a further need for more future prospective, randomized, and adequately powered interventional trials to determine whether early interventions based on input from capnography could improve clinical outcomes and reduce both DMV and mortality in these high-risk groups.

In this retrospective study of children having surgery requiring CPB for CHD, we found that higher AVDSf values in the immediate postoperative period are associated with mortality, DMV, and hospital LOS.

The online version contains supplementary material available at https:// doi. org/ 10. 1007/ s00246-021-02674-2.

Authors' Contributions IS participated in the conceptualization, methodology, data curation, and original draft preparation. SH participated in the conceptualization, methodology, and reviewing and editing of the manuscript. VR participated in the methodology, data analysis, and Receiver operation for AVDSf, arterial blood gases, serum lactate, mean arterial blood pressure, cerebral and renal rSO 2 at 23-24 h postoperatively to predict mortality, B) hospital LOS, and C) DMV. AUC and 95% confidence intervals (CI) for mortality ROCs are given

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