key: cord-0990405-difn43na authors: Ghram, Amine; Saad, Helmi Ben; Briki, Walid; Jiménez-Pavón, David; Mansoor, Hend; Moalla, Wassim; Akbari, Hesam Addin; Ghram, Abdeljelil; Al-Mohannadi, Abdulla Saeed; Arena, Ross; Lavie, Carl J title: Ramadan Intermittent Fasting, Physical Activity, and COVID-19 Pandemic in Patients with Chronic Diseases date: 2021-05-26 journal: Am J Med DOI: 10.1016/j.amjmed.2021.04.035 sha: bdd3dd6488a426a58892e6ad66635676babb8b16 doc_id: 990405 cord_uid: difn43na nan Ramadan 2021 is expected to begin on April 13, 2021, following the sighting of the moon. The practice of Ramadan entails refraining from eating food, drinking liquids, and other activities, such as smoking and sexual intercourse. From a medical standpoint, Ramadan intermittent fasting can be considered as a dietary intervention through which people intermittently fast with the potential benefit of improving the overall health. Importantly, the 2021 Ramadan is one of the most challenging fasting periods for Muslims given the Coronavirus disease 2019 (COVID-19) pandemic; the discovery of new Coronavirus mutations and persistent outbreaks around the globe continue to be of significant concern. In particular, coronavirus variants might be associated with increased mortality and have an impact on the individual's immune response and the effectiveness of newly developed coronavirus vaccines 1 . It is important to note that there is currently a lack of information on reasons for vaccination hesitancy, in particular the reluctance to receive the vaccination during this Islamic month of fasting over concern the vaccination invalidates the While preventive health measures aim to hinder the spread of COVID-19, there is a serious concern on the health status of vulnerable patient populations 8 In conclusion, the practice of fasting can improve the immune system, and the body's resistance to bacterial infections. An individual's decision on whether to fast or not, is influenced by several factors, such as knowledge, beliefs, attitudes, and physician's recommendations, as well as hesitancy surrounding safety concerns. Participating in regular physical activity while fasting and receiving a COVID-19 vaccination are important strategies to reduce risk of infection and improve general health. As this time, guidelines specifically tailored to patient populations engaged in fasting on how to perform physical activity during a pandemic are lacking, a knowledge gap that should be addressed in the future. In addition, health professionals must exercise sound judgment in providing physical activity recommendations to patients with medical conditions who choose to fast. Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study Ramadan and COVID-19 vaccine hesitancy-a call for action. The Lancet Physical activity for immunity protection: Inoculating populations with healthy living medicine in preparation for the next pandemic Physical exercise as therapy to fight against the mental and physical consequences of COVID-19 quarantine: Special focus in older people A tale of two pandemics: How will COVID-19 and global trends in physical inactivity and sedentary behavior affect one another? Progress in cardiovascular diseases Homebased exercise can be beneficial for counteracting sedentary behavior and physical inactivity during the COVID-19 pandemic in older adults Ramadan Fasting Exerts Immunomodulatory Effects: Insights from a Systematic Review Physical activity/inactivity and COVID-19 A systematic review on the effect of Ramadan on mental health: minor effects and no harm in general, but increased risk of relapse in schizophrenia and bipolar disorder Vaccine and physical activity in the era of COVID-19 pandemic. Progress in cardiovascular diseases