key: cord-0984631-dswbl6ke
authors: Ye, Bo; Deng, Hongbin; Zhao, Hanwei; Liang, Jingjing; Ke, Lu; Li, Weiqin; ,
title: Association between an increase in blood urea nitrogen at 24 h and worse outcomes in COVID-19 pneumonia
date: 2021-02-15
journal: Renal failure
DOI: 10.1080/0886022x.2021.1879855
sha: 0d05217adc42dfd4330c5fb9d3f568670a79d4dc
doc_id: 984631
cord_uid: dswbl6ke

nan

Since March 2020, coronavirus disease 2019 (COVID-19) has been declared a pandemic, which has been on escalation. Blood urea nitrogen (BUN) has been considered to be an independent risk factor for mortality in COVID-19 patients [1] . However, there is no study assessing the relationship of dynamic change in BUN and worse outcomes in COVID-19.

In this study, we included COVID-19 patients admitted to the Huoshenshan hospital from 5 Feb to 5 March in 2020, which is a newly established, referral, portable hospital for the outbreak of COVID-19 in Wuhan. And then we investigate the relationship between dynamic change in BUN and key clinical outcomes like transfer to intensive care unit (ICU), invasive mechanical ventilation, acute kidney injury (AKI), and in-hospital mortality.

Patients who had BUN level tested on admission and on the second day were considered eligible. Patients who had a known history of chronic kidney disease were excluded. Delta BUN was defined as the change of BUN from admission to 24 h after admission. The study population was divided into two groups according to their delta BUN during the first 24 h (Increase group and Non-increase group). On admission, the epidemiological data, comorbidities, vital signs, and laboratory examination of the study cohort were obtained.

There were 266 patients included for analysis. The mean delta BUN was 1.0 mg/dL (SD 9.5 mg/dL), with 206 patients (77.4%) experiencing a decrease or no change in BUN and 60 patients (22.6%) experiencing an increase. The proportion of patients with history of hypertension in the increase group is higher (55% vs. 37.4%, p < .05). Moreover, patients in the increase group had higher respiratory rate (22 ± 5 vs. 20 ± 3, p < .05), lower lymphocyte (LYM) (1.13 ± 0.90 vs. 1.31 ± 0.65, p < .05), albumin (ALB), and globulin (GLB) level (27.07 ± 3.93 vs. 28.33 ± 4.09, p < .05).

To evaluate the association between delta BUN and the in-hospital mortality and other clinical outcomes in COVID-19 patients in different subgroups, we analyzed the effect of delta BUN both in patients with normal admission BUN level (<20 mg/dL) or abnormal (!20 mg/dL) admission BUN level. Table 1 showed the in-hospital clinical outcomes of the study population, divided according to delta BUN (Increase vs. Non-increase). In-hospital mortality was significantly higher in the delta BUN increase group compared to no increase group (30.0 vs. 5.8%, p < .001). At the same time, in patients with normal or abnormal admission BUN, in-hospital mortality is also higher in delta BUN increase group (all p < .001). Moreover, patients in the delta BUN increase group also had a higher requirement of ICU admission, use of invasive mechanical ventilation and AKI (all p < .001).

The association between delta BUN (dichotomized as increase and non-increase) and the mortality of COVID-19 patients were further confirmed by logistic regression ( Table 2 ). After adjusted for age, gender, hypertension, chronic obstructive pulmonary disease (COPD), respiratory rate, LYM, ALB and GLO, delta BUN during the first 24 h after admission was independently associated with the inhospital mortality with an odds ratio (OR) of 7.427 [95% confidence interval (CI) 2.370-23.279].

The COX regression about delta BUN and the survival was summarized in Table 3 . Variables with a p value less than .05 in univariate regression analysis were included in the multivariate regression model. In the multivariable analysis, delta BUN (increase vs. no increase) and admission BUN (<20 mg/dL vs. !20 mg/dL) were both associated with survival rate. BUN increase remained an independent influential factor for survival with a hazard ratio (OR) of 6.838 [95% confidence interval (CI) 3.150-14.846].

Overall survival in patients with different delta BUN (increase or non-increase) is presented in Figure 1 . The survival curve of the increase group was significantly different from the no increase group (p < .001, Figure 1 (A)). In pairwise comparison, patients with increase delta BUN had significant lower overall survival rate than patients with no increase delta BUN in normal admission BUN group (<20 mg/dL) and abnormal admission group (!20 mg/dL) (Figure 1(B,C) ).

In this retrospective study, we observed that a substantial proportion of patients (18.4%) had elevated serum BUN value at admission. However, only 16.4% patients had increased BUN 24 h after admission. We found that both elevated BUN at admission and increased BUN within first 24 h were associated with higher in-hospital mortality.

Renal injury is not uncommon in patients with COVID-19, even in those who had no underlying kidney disease [2] . Early reports found that up to 30% of patients hospitalized with COVID-19 developed AKI [3] [4] [5] [6] . Elevated BUN at admission and increased BUN 24 h after admission may indicate early kidney injury. One possible explanation of the high prevalence of kidney involvement is the systemic immune response to the SARS-COV-2 can be detrimental in some patients, leading to so-called a cytokine storm. Besides, in kidney tissue and urine, SARS-CoV-2 RNA was also identified in COVID-19 patients [7, 8] . Therefore, the kidney may be a susceptible target of this novel coronavirus.

Apart from injury of the kidney, the delta BUN may also reflect patients' health condition. Patients with increased BUN had higher proportion of hypertension and COPD history and lower LYM, albumin and globulin level. Such patients may be functionally defective in innate and adaptive immune cell populations, making them vulnerable to COVID-19 and more likely to have worse prognosis. Therefore, monitoring BUN level might be of value. Early detection of potential or evidence AKI may facilitate appropriate treatment, including avoidance of nephrotoxic drugs and adequate fluid therapy.

In conclusion, we found that an increase in BUN at 24 h of hospitalization was associated with a composite of clinical outcomes and in-hospital mortality in patients with COVID-19. The importance of dynamically monitoring BUN may therefore be justified in the treatment of COVID-19. 

This study was approved by the medical ethics committee of Huoshenshan Hospital (HSSLL036). Written informed consent for publication was obtained from all participants.

Kidney disease is associated with in-hospital death of patients with COVID-19

COVID-19 and the kidney: a matter of concern

Acute renal failure during COVID-19 epidemic

Clinicopathological features and outcomes of acute kidney injury in critically ill covid-19 with prolonged disease course: a retrospective cohort

Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019

Acute kidney injury in critically ill patients with COVID-19

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Single-cell RNA sequencing analysis of human kidney reveals the presence of ACE2 receptor: a potential pathway of COVID-19 infection

We thank Research Square for posting this material in a preliminary form on 22 September 2020 [https://doi.org/10. 21203/rs.3.rs-74258/v1].

LWQ and KL design the work, YB, LJJ, and DHB collect the data, YB and DHB write the paper, DHB and ZHW analyzed the data. All authors have read and approved the final manuscript.

The authors declare that they have no competing interests.

This study was supported by the National Natural Science Foundation of China (81900593).

The data sets supporting the results of this article are included within the article. Some data used during the study are available from the corresponding author by request.