key: cord-0984513-4rxyyb7g
authors: Ziadi, Amra; Hachimi, Abdelhamid; Admou, Brahim; Hazime, Raja; Brahim, Imane; Douirek, Fouzia; Zarrouki, Youssef; El Adib, Ahmed R.; Younous, Said; Samkaoui, Abdenasser M.
title: Lymphopenia in critically ill COVID‐19 patients: A predictor factor of severity and mortality
date: 2020-09-30
journal: Int J Lab Hematol
DOI: 10.1111/ijlh.13351
sha: 44026cb885c56ca1942794c380cbce72ebcc4b6e
doc_id: 984513
cord_uid: 4rxyyb7g

nan

We read with interest the recent article by Terpos et al. 1 They reviewed different hematologic findings and complications of COVID-19. Especially, we are interested in lymphopenia in severe COVID-19 patients, which is a predictor factor of severity and mortality. We aimed to report the occurrence of lymphopenia, lymphocyte subsets, and its impact on ICU mortality in critically ill patients with COVID-19.

In this single-center cohort, we included adult patients with March 19, 2020 to May 15, 2020. We collected demographic data, comorbidities, clinical signs at the ICU admission, laboratory findings, chest CT scan if available, outcomes, time from onset of the first symptom to ICU admission, and sequential organ failure assessment (SOFA) scores. We expressed continuous variables as medians and interquartile (IQR) ranges or means (standard deviations (SD)), as appropriate, and compared using independent group Student's t test or the Mann-Whitney U test. Categorical variables were described using percentages and compared using the χ 2 -test, although Fisher's exact test was used when the data were sparse. We performed univariable to evaluate the risk factors of mortality. The analysis was processed by spss 10.0 for Windows (SPSS, Chicago, IL, USA). A Pvalue of <.05 was considered statistically significant. We noted that lymphopenia <1000/mm 3 was present in 53% of our patients. We performed lymphocyte subset counts in 43.6%

(24/55) of cases on admission (Table 1) 

All authors declare no competing interests. 

Hematological findings and complications of COVID-19

Lymphocyte subset (CD4+, CD8+) counts reflect the severity of infection and predict the clinical outcomes in patients with COVID-19

Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia

Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a systemic review and meta-analysis

Association of cardiac injury with mortality in hospitalized patients With COVID-19 in Wuhan, China

Risk factors associated with acute respiratory distress syndrome and death in patients with Coronavirus Disease

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study

Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage