key: cord-0984067-snjp1hqw
authors: Luo, Mengqiang; Mei, Zubing; Wei, Liqun; Cao, Shu mei; Su, Shiheng; Wang, Yingwei
title: Precautions for weaning from invasive mechanical ventilation with critically ill COVID-19
date: 2020-07-09
journal: Heart Lung
DOI: 10.1016/j.hrtlng.2020.07.005
sha: 358bd0fca82661421d552adaf675275d380f3462
doc_id: 984067
cord_uid: snjp1hqw

nan

The coronavirus disease (COVID-19) pandemic remains an ongoing threat worldwide. By July 3, 2020 there had been 517,337 confirmed deaths and 216 countries and territories were affected. 1 This has created a major challenge worldwide, especially for patients with limited health care coverage. COVID-19 has a broad spectrum of clinical severity. Approximately 5-20% of those who are hospitalized are admitted to the intensive care unit because of acute respiratory failure, shock, and multiple organ dysfunction. 2 In China, 6-47% of critically ill COVID-19 patients received intubation and invasive mechanical ventilation (IMV) support, [2] [3] while this figure goes up to 71-75% in the United States, [4] [5] and 88% in Italy. 6 Moreover, the mortality rate among intubated COVID-19 patients is reported to be as high as 97% 7 . An early study conducted in Wuhan reported that 31 of the 32 patients who received IMV support died.

Recently, 56.5-62.1% of patients were reported to be successfully extubated eventually, which suggests that better outcomes after intubation are extremely concerning for the survival of critically ill COVID-19 patients. [8] [9] COVID-19 leads to an atypical form of acute respiratory distress syndrome with relatively well-preserved lung compliance despite severe hypoxemia, and no specific antiviral drug has been identified. Extubation is a high-risk procedure in patients with COVID-19 because of direct contact with patients and exposure to airway droplets and aerosols. Therefore, it is critical to ensure that the decision to extubate is appropriate so that the patients are not harmed by extubation, and the hazards related to the cycle of reintubation and extubation are avoided. A protocol that facilitates the decision-making and execution of extubation in COVID-19 patients is warranted.

An important goal of extubation is to ensure that patients tolerate extubation and to minimize the chance that they will require reintubation. High-risk factors for reintubation include age, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Rapid Shallow Breathing Index (RSBI), and positive fluid balance. A low PaO 2 /FiO 2 ratio at extubation may be a risk factor for reintubation due to respiratory insufficiency. 10 Hence, patients should have a patent airway, adequate ventilation and gas exchange capacity with minimal or no respiratory stress before extubation. Daily spontaneous breathing trials, with pressure support for 30 minutes or T-piece ventilation for 2 hours should be performed to determine whether patients are ready for discontinuation of IMV support. Progressive reduction of pressure support and daily spontaneous breathing trials are satisfactory methods of weaning in COVID-19 patients. It should be ensured that the established criteria are met before starting spontaneous breathing trials 11 (Table 1) . For instance, a chest X-ray is needed to demonstrate remission of the lung disease ( Figure 1 ) and the PaO 2 /FiO 2 ratio should be above 200 mmHg.

Some details need to be highlighted. A humidifier with a virus-filtering function should be used when modified T-piece ventilation is needed. Gentle in-line closed suction should be used to clean airway secretions (Figure 1 ). Because the dispersion distance of exhaled air can range from 42 to 99 mm and that from coughing bouts may range up to 460 mm, multiple strategies should be used to reduce droplet spread during extubation. These may include covering the patient's mouth and nose with a wet gauze, plastic drapes, or a box; halting flow of oxygen with gauze; clamping the endotracheal tube; and use of suctioning devices. 12 Furthermore, "Mask-Over Tube Extubation" technique may enable the anesthetist to avoid direct exposure to droplets or aerosols produced by extubation or associated coughing. 13 Measures such as dexmedetomidine or remifentanil infusion and intravenous lidocaine maybe useful to prevent agitation, coughing, and bucking. Supraglottic airways and airway exchange catheter are not recommended in COVID-19 patients due to the potential for coughing.

The planned use of non-invasive ventilation (NIV) after extubation is recommended in high-risk patients to reduce the chance of extubation failure. Strategies for supporting respiration after extubation, such as NIV and high-flow nasal oxygen, are relatively contraindicated due to their ability to aerosolize viral particles. However, during the severe acute respiratory syndrome epidemic NIV did not appear to be associated with an increased risk of transmission of the virus to healthcare workers. 14 Minimizing unnecessary patient and surface contact, and careful waste management, are essential for risk reduction. Healthcare workers who are involved in the extubation process should wear standard Level 3 personal protective equipment, including a powered air-purifying respirator system.

In conclusion, meticulous considerations are needed to ensure the quality of care, decrease the chance of reintubation, and ensure the safety of healthcare workers when weaning critically ill COVID-19 patients from invasive mechanical ventilation. patients.Written consent for publication was obtained from patient.)

World Health Organization: Coronavirus disease (COVID-19) Dashboard, Last update: 3

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1.1 Clinical criteria to be met before starting SBT for COVID-19 11 1 . bedside x-rays suggest lung disease remission or absorption;