key: cord-0982945-etbyyp3r
authors: Sriwijitalai, Won; Wiwanitkit, Viroj
title: Comparative nanostructure consideration on Wuhan novel coronavirus and possibility of transplacental transmission
date: 2020-08-25
journal: Am J Obstet Gynecol
DOI: 10.1016/j.ajog.2020.08.061
sha: 5c46a4802f29343fd2c8229b878012b66f85582a
doc_id: 982945
cord_uid: etbyyp3r

nan

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier Inc. [1] . The disease is a respiratory disease and the transmission from human to human via airborne mode is confirmed. In gynecology, the effect of COVID-19 during pregnancy is a trop for further study. As noted by Rasmussen et al. [2] , there are many issues obstetricians need to know. Of several issue, the finding of infection in neonate born to infected mother draws attention of the medical society of the possible transplacental mode of transmission.

In fact, many viruses can pass placenta from mother to child and cause infection. The good example is HIV and hepatitis virus [2 -3] . Based on nanomedicine concept, the transplacental transmission of HIV is explainable by the viral particle size and placenta pore size [2] . Conceptually, the viral pathogen that is smaller than placental pore size can pass the placenta and further cause neonatal infection. Applied the comparative nanostructure complete for the novel coronavirus infection, the estimated size of the virus is about 50 -120 nm. This size is considered larger than the placenta pore size (about 10 nm). Therefore, it is unlikely that transplacental transmission of novel coronavirus can occur if there is no placental pathology. Indeed, the observations from China also show no case of vertical transmission [5] . The neonatal Wuhan coronavirus infection should be due to respiratory transmission from closed contact with mother.

Emerging new coronavirus infection in Wuhan, China: Situation in early 2020

Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know

Re: HIV transmission from mother to child: an aspect on the placenta barrier at the nano-level

New emerging blood-borne hepatitis viral pathogens and the feasibility of passing thorough the placenta: an appraisal

Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China. Emerg Infect Dis