key: cord-0982858-rwqlthmf authors: Villanego, Florentino; Cazorla, Juan Manuel; Vigara, Luis Alberto; Garcia, Teresa; Trujillo, Teresa; Montiel, Natalia; Rodriquez‐Iglesias, Manuel; Mazuecos, Auxiliadora title: Protecting kidney transplant recipients against SARS‐CoV‐2 infection: A third dose of vaccine is necessary now date: 2021-09-07 journal: Am J Transplant DOI: 10.1111/ajt.16829 sha: 2aeea4129f0beeb79105a9587f3dc037762ddf3e doc_id: 982858 cord_uid: rwqlthmf We have read the article written by Ison et al. (1) that has raised some issues we would like to discuss. COVID-19 breakthrough infection rates in vaccinated kidney transplant (KT) recipients much higher than in the general vaccinated population have been reported (2). Furthermore, the severity remains markedly high. Although Ison et al. referred cases are rarely severe, other series, and among them the largest cohort published so far, have reported 27% of very serious cases (3). To the Editor: We have read the article written by Ison et al. 1 that has raised some issues we would like to discuss. COVID-19 breakthrough infection rates in vaccinated kidney transplant (KT) recipients much higher than in the general vaccinated population have been reported. 2 Antibodies, boosters, and optimizing SARS-CoV-2 vaccines for transplantation: a call for more research Risk of breakthrough SARS-CoV-2 infections in adult transplant recipients Occurrence of severe COVID-19 in vaccinated transplant patients Covid-19 breakthrough infections in vaccinated health care workers Efficiency of a boost with a third dose of anti-SARS-CoV-2 messenger RNA-based vaccines in solid organ transplant recipients