key: cord-0981305-reri5082 authors: Rossi, Rosario; Coppi, Francesca; Monopoli, Daniel Enrique; Sgura, Fabio Alfredo; Arrotti, Salvatore; Boriani, Giuseppe title: Pulmonary arterial hypertension and right ventricular systolic dysfunction in COVID-19 survivors date: 2022-02-23 journal: Cardiol J DOI: 10.5603/cj.a2021.0159 sha: 314ade19bd80137456b60118b439de95173d23ed doc_id: 981305 cord_uid: reri5082 nan Although much has been published about the in-hospital prognosis of COVID-19 patients, much less attention has been paid to what happens to those who have been discharged alive from the hospital [1] . In the present study we investigated a group of patients initially admitted for acute respiratory failure due to coronavirus disease 2019 (COVID-19)-related interstitial pneumonia and then, at a later time point, discharged from hospital. We noted that some of these patients presented a specific cluster of signs and symptoms: asthenia, fatigue, high heart rate (HR) at rest, and tachycardia disproportionate to physical exertion [2] . These patients find it difficult to resume their social and working life after discharge. We can say that these symptoms and signs fall within the generic definition of "post-COVID syndrome" [3] , but we do not know the origin and causes of this clinical condition. We then performed a right heart catheterization (RHC) in all these patients, in order to evaluate the possible presence of cardiac and/or pulmonary vascular alterations. The study group consisted of 25 consecutive patients, COVID-19 survivors, referred to our divisional outpatient clinic for the cluster of signs and symptoms described above. All patients were hospitalized between March 2020 and February 2021. In all these patients we performed a RHC and a 6-minute walking test (6MWT). The obtained results were compared with those of a control group, which comprised 25 gender-and age-matched patients, COVID-19 survived, but asymptomatic. Patients with pulmonary hypertension (PH) underwent an additional 6MWT and catheterization every 6 months of follow-up. The present study was approved by the local Ethical Committee (protocol number: AOU 0012597). Right heart catheterization was performed using a 7 F balloon-tipped (Swan-Ganz catheter), triple lumen thermodilution catheters. Right atrial pressure (RAP), mean pulmonary artery pressure (mPAP), and pulmonary capillary wedge pressure (PCWP) were recorded. Cardiac output (CO) was determined by thermodilution method. Cardiac index (CI = CO/body surface area), right ventricle stroke volume (RVSV = CO/HR), and pulmonary vascular resistance [PVR = (mPAP − PCWP)/CO] were calculated. Right ventriculography was performed in the 30° right anterior oblique view using a 6 F pig-tail catheter. Right ventricular (RV) end-diastolic diameter (EDD) and ejection fraction (EF) were calculated. Continuous variables were expressed as mean ± ± standard deviation or median (range) values, and categorical data as percentages. All dichotomous variables were compared applying the c 2 test; continuous variables using one-way analysis of variance. Changes from baseline to follow-up were assessed using analysis of variance for repeated measures. Bonferroni's correction was utilized for multiple comparisons. P < 0.05 was considered statistically significant. Our study population comprised 25 patients hospitalized for acute respiratory failure due to COVID-19 interstitial pneumonia, confirmed by chest computed tomography images. The comparison between symptomatic patients and the control group is depicted in Table 1 . Twenty-one patients/25 (84% of the entire population) had an additional control after 6 months, and 15/25 (60%) one more after 1 year of follow-up. In these patients we noted a significant improve- Table 1 . Comparison between symptomatic (study group) and asymptomatic (control group) post--COVID-19 patients. Both groups consisted of patients who survived SARS-CoV-2 infection, but only patients included in the study group suffered from the specific cluster of the following signs and symptoms: asthenia, fatigue, elevated heart rate at rest, and tachycardia disproportionate to exertion. The control group consisted of asymptomatic patients of equal age and gender. ment in pulmonary pressure (mPAP passed from 23 ± 2 to 20 ± 4 mmHg after 6 months, to 18 ± ± 5 mmHg after 1 year of follow-up; p = 0.01 for all comparisons); a significant increase in RV systolic performance (RVSV moved from 59 ± 8 to 66 ± ± 10 mL at 6 months, and 72 ± 12 mL after 1 year; p = 0.01); associated with a significant amelioration of 6MWT (from 420 ± 45 to 495 ± 40 m after 6 months, to 520 ± 35 m after 1 year; p = 0.001). All patients who presented the following cluster of signs/symptoms: asthenia, fatigue, high HR at rest, and tachycardia disproportionate to physical exertion, suffered from mild degree pulmonary arterial hypertension (PAH) and severe RV systolic dysfunction. We found a perfect match between this hemodynamic status and the described clinical condition. All our symptomatic patients presented a mPAP > 20 mmHg, a value already indicative of PH according to the 6 th World Symposium on Pulmonary Hypertension of Nice, 2018 [4] . In addition, RVSV and EF were both reduced by about 40% compared to the asymptomatic (control) group. Our hypothesis would be that, in relation to the parenchymal ("ground-glass" and "dense" opacifications) and vascular pulmonary involvement (markedly impaired pulmonary perfusion, caused by pulmonary angiopathy and thrombosis) that occurs during the acute phase of pneumonia [5, 6] , an increase in PVR develops, with a consequent onset of PH [7] . RV normally works at an extremely low level of afterload, and the muscle thickness of its free wall is not particularly conspicuous. However, when the RV is stressed by an increase in afterload, its internal cavity gradually expands [8, 9] . In this phase of the disease, the right atrium acts as an effective pump in the late diastole. The pressure in the right atrium consequently increases. The intensification of the right atrium contractile efficiency implies a recruitment of preload, which has the function of more effectively filling the underlying ventricle. According to the Frank-Starling principle, the RV increases the stroke volume [9] . Furthermore, the most important and timely compensatory mechanism capable of maintaining an adequate CO, represented by the stimulation of the sympathetic-adrenaline reflex, becomes active from the earliest stages of the disease, which leads to positive chronotropic and inotropic effects [10] . In conclusion, there is a phase of COVID-19, after discharge, characterized by PAH and RV systolic dysfunction. As long as this state persists, patients suffer from a specific cluster of symptoms and signs. Our results allow us to assume that recovery of normal RV function is gradual and spontaneous. In other words, the RV initially sustains an increase in pulmonary resistance, and then gradually resumes its function, as after a "stunning". However, it is noticeable that the disappearance of symptoms is always accompanied by improvement of the RV systolic performance. Low physical functioning and impaired performance of activities of daily life in COVID-19 patients who survived hospitalisation What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol COVID--19-ALC research group. Post-acute COVID-19 syndrome. 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