key: cord-0980365-rx9wn36t
authors: Murt, Ahmet; Eskazan, Ahmet Emre; Yılmaz, Umut; Ozkan, Tuba; Ar, Muhlis Cem
title: COVID‐19 presenting with immune thrombocytopenia: a case report and review of the literature
date: 2020-06-04
journal: J Med Virol
DOI: 10.1002/jmv.26138
sha: 649f2077e15e2d1052d67a242a20871ce68dca60
doc_id: 980365
cord_uid: rx9wn36t

Novel coronavirus disease (COVID‐19) may be associated with thrombocytopenia which might have different mechanisms in different patients and in different phases of the disease. Cytokine release, thrombotic consumption or autoimmune destruction are some leading etiologies of thrombocytopenia in COVID‐19. This case report presents a 41‐year‐old male COVID‐19 patient who had petechiae and purpura as the referral symptoms. Laboratory tests revealed isolated thrombocytopenia with no other additional pathologic findings. Most probable diagnosis was COVID‐19 induced immune thrombocytopenia (ITP) and high dose intravenous immunoglobulin (IVIg) treatment generated a good response. There were four other recent publications with a total of eight cases in the literature. The presented case was discussed in comparison with those similar cases. This article is protected by copyright. All rights reserved.

Mild thrombocytopenia (platelet counts of 100-150 x 10 9 /L) can be observed in novel coronavirus disease , however severe thrombocytopenia is rare 1 . COVID-19-associated thrombocytopenia can be due to; the direct invasion of bone marrow, This article is protected by copyright. All rights reserved.

cytokine release leading to hemophagocytic lymphohistiocytosis, autoimmune destruction of platelets in peripheral blood (immune thrombocytopenia -ITP), and increased platelet consumption as a consequence of thrombi in the microvasculature 2 .

Severe thrombocytopenia (< 50 x 10 9 /L) was related to poor prognosis in a recent COVID-19 cohort where thrombocytopenia was attributed to coagulopathy related consumption 3 .

We herein report a mild disease course in a patient who had COVID-19-induced severe thrombocytopenia, along with the recently published similar cases in the literature.

A 41-year-old male was presented with petechiae and nasal bleeding. He had cough and runny nose 15 days ago, which resolved recently. He was diagnosed as ITP and referred to our center after 4 days of high-dose dexamethasone therapy, which was not effective.

His medical history was otherwise unremarkable. Physical examination was normal except for petechiae and purpuric rash. Upon admission, he had isolated thrombocytopenia (9 x 10 9 /L). In the differential diagnosis of isolated thrombocytopenia, the patient did not have consumption coagulopathy or thrombotic microangiopathy with no schistocytes or blasts in the peripheral blood smear. Laboratory tests including viral hepatitis panel and rheumatological markers did not reveal any cause of thrombocytopenia, and the diagnosis of ITP was made.

Since he had cough and runny nose recently, a nasopharyngeal swab was sent for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) real time polymerase chain reaction (RT-PCR), which came out to be positive. His chest computerized tomography This article is protected by copyright. All rights reserved.

showed bilateral ground glass opacities consistent with COVID-19 pneumonia.

Favipiravir was prescribed as the antiviral agent, and his pneumonia gradually resolved in five days.

As ITP secondary to COVID-19 was the most likely diagnosis, intravenous immunoglobulin (IVIg) with a total dose of 2 g/kg was administered concomitantly with favipiravir in the first two days of admission. After the treatment, his platelet count was 54 x 10 9 /L, and during 4-weeks of follow-up, platelet counts were between 50-100 x 10 9 /L.

Recently there have been published cases of isolated severe thrombocytopenia associated with COVID-19 (Table) . Among them, two patients (Patients #1 and #2) were presented as ITP with no fever or respiratory symptoms 4 . Additional two patients (Patients #5 and #6) who were presented with ITP had prior fever and respiratory symptoms, starting 10 and 21 days before referral, respectively 5 . Similar to our patient, these four cases were also responsive to high-dose IVIg. Thrombocytopenia was detected relatively later in the other four cases (Patients #3, #4, #7, and #8) 4-6 . Patients #3 and #7 developed thrombocytopenia on the 5 th and 12 th days of admission respectively, and thrombocytopenia in both cases coincided with clinical deterioration. Patient #4 had used amoxicillin-clavulanic acid and low-molecular-weight-heparin prior to the detection of thrombocytopenia 6 , which might also be related to thrombocytopenia. IVIg was not effective in these patients (#3, #4 and #7). Patients #3 and #7 died because of COVID-19 progression, whereas prednisolone and eltrombopag were administered in Patient #4, This article is protected by copyright. All rights reserved.

which induced a good response. Another patient (Patient #8) developed thrombocytopenia on 16 th day of admission, which was 29 days after the initiation of respiratory symptoms 7 . That patient had a stable disease course and was in the recovery stage. His platelet counts recovered following IVIg administration.

Thrombocytopenia has been defined as a poor prognostic factor in COVID-19 8 , but thrombocytopenia in the disease course is not of one kind. Cytokine release or thrombi in the microvasculature may be responsible for platelet consumption in clinically 

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