key: cord-0977722-kvezwqeb
authors: Arnold, David T.; Milne, Alice; Samms, Emma; Stadon, Louise; Maskell, Nick A.; Hamilton, Fergus W.
title: Symptoms After COVID-19 Vaccination in Patients With Persistent Symptoms After Acute Infection: A Case Series
date: 2021-05-25
journal: Ann Intern Med
DOI: 10.7326/m21-1976
sha: 6227462c421c2a40e87332df330140b19b63b4af
doc_id: 977722
cord_uid: kvezwqeb

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with other observational studies of vaccine adverse effects in persons with previous SARS-CoV-2 infection (5) . No difference in any outcome measure was identified between the Pfizer-BioNTech (n = 18) and Oxford-AstraZeneca (n = 18) vaccines (t test P > 0.1 for all comparisons).

Discussion: This report presents a series of patients with robust measures of quality of life and symptoms both before and after vaccination. Limitations include the small sample size and the inability to blind participants to their vaccination status. Also, because the U.K. national policy prioritized vaccination for older age groups and adopted a delayed second-dose approach, it was not possible to suitably match vaccinated and unvaccinated persons, and we can only provide data for participants after their first vaccine dose. However, these observations may provide reassurance to the increasing number of persons experiencing long-term symptoms after acute SARS-CoV-2 infection that receipt of a messenger RNA or adenoviral vector vaccine is not associated with a decrease in quality of life or worsening of symptoms. Further work that includes appropriate unvaccinated controls is needed to confirm the trajectory of persistent symptoms after COVID-19 vaccination. 

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