key: cord-0976618-xtzpdewk
authors: Marinho, Paula M.; Nascimento, Heloisa; Marcos, Allexya A. A.; Romano, André C.; Rosen, Richard B.; Belfort, Rubens
title: Reply to Editorial: Interpretation of OCT and fundus findings in COVID-19 patients in recent Lancet publication
date: 2020-11-25
journal: Eye (Lond)
DOI: 10.1038/s41433-020-01283-2
sha: f09f491160eacf5e67323a8e1d78caab02a915c8
doc_id: 976618
cord_uid: xtzpdewk

nan

We have read the Editorial [1] regarding our publication [2] and would kindly request to respond in order to clarify our original observations. Our patients' age ranged from 25 to 69 years old (mean: 43 years; median: 40 years). Of the 12 patients from our original report, seven had no comorbidities, one had controlled type 2 diabetes and high blood pressure (HBP), two had HBP with good clinical control, one had a history of dyslipidemia, and one had ankylosing spondylitis, controlled with adalimumab, and no history of ocular involvement.

We do agree that cotton wool spots (CWS) can be identified in a broad spectrum of diseases. On Fig. 1 we present a follow-up composite of the patient presented at the Lancet Publication showing regression of the cited lesion. The CWS image was not a NFL myelination and disappeared as expected.

At present moment we have seen close to 200 patients, ranging from asymptomatic to deceased after intensive care unit admission. To better illustrate our findings, we present images from a 52-year-old female, who was nasal swab positive for SarS-CoV-2, hospitalized for hypoxia, displaying subtle CWS in the right eye (OD) and no alterations in the left eye. Our findings are consistent with other reports that are now been presented [3] [4] [5] . We do appreciate all the input received. More data regarding our studies will be promptly presented.

Conflict of interest The authors declare that they have no conflict of interest.

Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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A composite with fundus exam and OCT from the same patient from Fig. 2 showing lesion's evolution. a1 and a2 were taken on 1st evaluation, b1 and b2 were taken after 37 days