key: cord-0975238-4299fm1a
authors: Long, Ann; Grimaldo, Felipe
title: Authors response to “A more realistic relationship between covid 19 and hemopneumothorax” (MS 24398)
date: 2020-09-09
journal: Am J Emerg Med
DOI: 10.1016/j.ajem.2020.09.015
sha: 70eb6f802bd327f21ea29695cadd1b31187b3edf
doc_id: 975238
cord_uid: 4299fm1a

nan

Declarations of interest: The views expressed in this case report are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the United States Government. We are military service members. This work was prepared as part of our official duties. Title 17 U.S.C. 105 provides that "Copyright protection under this title is not available for any work of the United States Government." Title 17 U.S.C. 101 defines a United States Government work as a work prepared by a military service member or employee of the United States Government as part of that person's official duties.

Thank you for your comments on our case report and providing us with the opportunity to discuss the possible relationship between COVID-19 and hemopneumothorax. As new information about this disease surfaces daily, we as clinicians must strive to consider novel possibilities for pathophysiology.

The comments propose that COVID-19 would be more likely to result in spontaneous hemothorax via pulmonary emboli (PE) and the subsequent anticoagulant therapy. Indeed, COVID-19 is well known for predisposing patients to thrombotic disease, both in venous and arterial circulations [1] . PE can then lead to both spontaneous pneumothorax (SP) and spontaneous hemopneumothorax (SHP) by way of pulmonary infarction and cavitating lesions [2] [3] . Pulmonary infarction is a less common complication of PE, with an incidence ranging from 16-31% [4] [5] . From the documented cases of SP complicating infarction, the time interval from embolus to pneumothorax may be as long as 5 weeks [2] . Thus, it does seem feasible that a PE would lead to SHP, especially in subacute presentations of COVID-19.

However, because SHP is primarily associated with SP, it will be of interest to note from future studies if patients with COVID-19 have a higher risk of developing SP than the general population, which has an overall incidence of 17-24 per 100,000 in males and 1-6 per 100,000 in females [6] . The mechanism of SP formation in COVID-19 patients is uncertain. It is speculated that the severe inflammatory response gives rise to SP due to degenerative changes in the lung parenchyma [7] . Histologic examinations show diffuse alveolar damage with cellular fibromyxoid exudates, which lead to formation of cystic lesions and alveolar rupture [8] .

Currently, there have been multiple case reports of SP and COVID-19, but only a single retrospective review from China citing a 1% incidence [9] , which is likely an underestimation as only 99 patients were included and the review was published in the early months of the J o u r n a l P r e -p r o o f pandemic. If it is shown that COVID-19 patients have an increased risk of SP, it would follow that these patients may also be at increased risk of SHP. Therefore, it is possible that our case of SHP was due to the inflammation caused by COVID-19, especially since the patient was not previously diagnosed with PE, nor was the patient anticoagulated [10] .

Multiple other studies of clinical characteristics have been performed, but none have specifically addressed the rates of SP. We look forward to future research into the clinical presentations of this novel disease.

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-ofthe-Art Review

Secondary spontaneous pneumothorax: a rare complication of pulmonary embolism

Spontaneous haemopneumothorax due to cavitating pulmonary infarction -a rare condition revisited

Predictors of Pulmonary Infarction

Pulmonary infarction secondary to pulmonary embolism: An evolving paradigm

The Evolving Epidemiology and Management of Spontaneous Pneumothorax

COVID-19 with cystic features on computed tomography: a case report

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

Spontaneous hemopneumothorax in a patient with COVID-19: A case report