key: cord-0973610-xtr8h4p7
authors: Scheidt-Nave, Christa; Barnes, Benjamin; Beyer, Ann-Kristin; Busch, Markus A.; Hapke, Ulfert; Heidemann, Christin; Imhoff, Maren; Mumm, Rebekka; Paprott, Rebecca; Steppuhn, Henriette; von Berenberg-Gossler, Petra; Kraywinkel, Klaus
title: Care for the chronically ill in Germany – The challenges during the COVID-19 pandemic
date: 2021-02-17
journal: J Health Monit
DOI: 10.25646/7168
sha: 0cacad0fe0170e0233bca30d6925df03dc9d0939
doc_id: 973610
cord_uid: xtr8h4p7

The COVID-19 pandemic is posing major challenges to the health care sector. This scoping review compiles evidence concerning changes to health care service availability and utilisation as well as possible impacts on health for selected groups of chronically ill people in Germany. The focus is on cancer, cardiovascular diseases, diabetes mellitus and mental disorders. Most empirical data available concerned inpatient care and showed a clear decline in the utilisation of inpatient treatments in March and April 2020 in the areas of oncology and cardiology as well as in mental health. For cardiovascular emergencies such as heart attack and stroke, a decline was observed especially regarding less serious cases. Although there were indications of treatment delays, there was no evidence thus far that emergency care had been generally compromised due to adjustments to inpatient care capacities. In the outpatient setting, extensive adjustments to health care services availability were observed for all disease groups considered. Overall, very limited empirical data were available. In particular, hardly any data were available on how changes in care impacted population health. There is an urgent need for continuous surveillance and evaluation based on health care and epidemiological data.

To contain the spread of SARS-CoV-2 infections and prevent overburdening the health care system, Germany, among other countries, implemented a set of non-pharmaceutical interventions (NPI) beginning in mid-March 2020. These included, on the one hand, measures to reduce physical contact and recommendations for social distancing [1] . On the other hand, adjustments to all ar eas of medical care were introduced. For example, inpatient treatment capacity, especially intensive care capacity for COVID-19 patients, was expanded and elective (postponable) surgery at all hospitals was postponed until further notice [2] .

Results of international studies suggest that treatment figures for people with common noncommunicable diseases have decreased during the COVID-19 pandemic in many countries, at least temporarily. The reasons for this are manifold. Restrictions on the availability of care seem to have played as large a role as has a reluctance of patients to utilize services [3] [4] [5] [6] [7] [8] . A recent World Health Organization (WHO) survey of health ministries in 160 countries [9] showed that the extent and duration of health care shortfalls are determined to a large extent by type of disease, 3 FOCUS presentation and description of the identified study types, central concepts and results is prepared.

To identify relevant literature, a search was conducted for peer reviewed publications in the PubMed and COVID-19_MAP literature databases. To include commentaries from stakeholders, grey literature (non-publisher-bound publications) and opinions of experts [15, 16] , an additional keyword search in Google and Google Scholar and on the websites of selected organisations was carried out, and sources cited in reference lists were taken into account.

Our search covered the period from 1 March to 19 June 2020 (for Google Scholar from 2020 on) with a focus on publications pertaining to cancer, cardiovascular diseases, diabetes mellitus and mental disorders. For each of the four subject areas considered, the electronic PubMed literature database was systematically searched with four different search queries in English (the search strings used are available on request from the corresponding author). In order to ensure the greatest possible congruence in the topic-specific search, all search queries contained a core of combined search terms for SARS-CoV-2 and COVID-19. This core was linked with further combinations of search terms specific to the respective disease groups. Simpler combinations of search terms were used for the additional searches in Google and Google Scholar and for searches on the websites of relevant professional societies, extent of regional SARS-CoV-2 infections and by pre-existing differences in the capacities of individual countries' health care systems to provide and adapt their services.

This article reviews changes in the health care situation of patients with selected noncommunicable diseases in Germany between the beginning of March and mid-June 2020. The focus is on cancer, cardiovascular diseases, diabetes mellitus and mental disorders. All these diseases require continuous and quality-assured care, some within the framework of structured disease management programmes (DMPs). In addition, study data show that patients with diabetes, cardiovascular diseases and some cancers may be at increased risk of developing severe symptoms in the course of a COVID-19 infection [10] [11] [12] [13] . The following questions should be answered: (1) How have availability and uti lisation of health care services changed for these groups of chronically ill people in Germany following the introduction of NPIs to control the spread of SARS-CoV-2? (2) Is there evidence that such measures have affected the health and well-being of chronically ill people? On the basis of this review, we will identify areas where there are obvious gaps in the available evidence and in which new questions arise that require continued and more in-depth work.

The included sources were stratified by disease area, and essential information was extracted and tabulated using a predefined matrix. In addition to bibliographic information, responsible stakeholders or institutions, key contents and results as well as the type of publication were documented. Regarding the type of publication, a distinction was made between empirical studies with their own data basis and non-empirical studies (e.g. commentaries, recommendations, information and communications). All results of the literature search were summarised in two tables (Table 1 and Table 2 ), corresponding to the two questions posed above (changes to health care services availability and uti lisation, effects on health and wellbeing).

professional associations and patient organisations. The literature searches were stratified by disease group and carried out by at least one person per group. At least two co-authors were involved in screening and selecting the literature search results for each disease group. Unclear or conflicting screening decisions were discussed, and consensus was reached among the co-authors involved.

All German-and English-language contributions relating to the health care of patients with cancer, cardiovascular diseases, diabetes mellitus or mental disorders in Germany were included. Contributions that related exclusively to cancer screening examinations or to persons in outpatient home nursing care or long-term residential care were excluded. Report that invasive examinations and procedures (e.g. cardiac catheters, stent implantations) were sometimes only carried out after a waiting period of two to three weeks or were then scheduled at extremely short notice (on the same day), lack of capacity led to patients being treated at more distant clinics, cardiologists in private practice increasingly took over the outpatient care of patients who would normally have been monitored as inpatients Diabetes mellitus 1 [37, 49] Federal Joint Committee (G-BA) Recommendations to suspend compulsory patient training and medical examinations in the context of disease management programmes (temporary special arrangement) Communication by the medical society on the postponement of treatment in psychiatric hospitals and the replacement of inpatient services with outpatient services to ensure care in acute crisis situations 1 [95] National contact and information point for the motivation and support of self-help groups (NAKOS)

Information on changes to available care services in support of selfhelp groups for mentally ill persons, self-help contact points were closed and only accessible by telephone/email, group meetings or personal exchanges were not possible 1 [96] Federal Chamber of Psychotherapists (BPtK) Information on possible switches to telephone and video appointments as well as online interventions for treatment and therapy 1 [50] Federal Chamber of Psychotherapists (BPtK) Information on the expansion of existing telephone services and the development of new services and more specific local therapy and counselling services 1 [97] German Society for Psychology (DGPs) Opinion from this medical society on the need to allow emergency childcare in day-care centres and schools to children and adolescents with mental health problems and of mentally ill parents if needed * 1 non-empirical studies, e.g. discussion papers, recommendations, information and communications 2 empirical studies, e.g. surveys, analyses of insurance data or inpatient data Continued on next page Survey of breast cancer centres worldwide, including more than 30 facilities in Germany; increase in genetic diagnostics before possible neoadjuvant treatment (treatment to reduce the size of a tumour before surgery)

Martini-Klinik at the University Medical Center Hamburg-Eppendorf (UKE)

Discussion of experiences of the clinic regarding the cancellation of operations by patients and the clinic, temporary slight decrease in admissions Cardiovascular diseases 2 [51] Institutes of nuclear medicine in Germany, Austria and Switzerland (participating institutes in Germany: University Hospital Essen, Centre for Radiology and Nuclear Medicine Rhineland)

Survey in hospitals and practices showed a decrease in the number of outpatient myocardial scintigraphies carried out, with greater differences in hospitals than in private practices (survey between 14 April and 20 April 2020 on changes in the previous three weeks)

1 [31] German Cardiac Society (DGK) Report on a nationwide decline in heart surgeries by 60%, also in cases with more urgent indications (to be performed within 30 days) * 1 non-empirical studies, e.g. discussion papers, recommendations, information and communications 2 empirical studies, e.g. surveys, analyses of insurance data or inpatient data Continued on next page For patients with cardiovascular diseases, the pandemicrelated adjustments also led to restructuring of inpatient care capacities. For example, hospital beds in dedicated wards for patients with acute stroke (stroke units) or with acute chest pain (chest pain units) were partly converted into intensive care beds [24, 25] . According to the medical societies, however, the care of patients with cardiovascular diseases could still be fully assured [26] [27] [28] . In addition, by simplifying approval procedures for rehabilitative follow-up treatment, transfers to rehabilitation clinics were accelerated [26, 29] . However, medical professional associations have reported that invasive examinations and procedures (e.g. cardiac catheterisation and stent implantation) were sometimes only carried out after a two-to three-week waiting period and that an increasing number of patients had to visit more distant clinics [30] . Moreover, cardiologists in private practices increasingly took over treatment of patients who otherwise would have been admitted as inpatients for observation [30] . According to the German Society of Cardiology (DGK), the call to postpone elective operations resulted in a significantly lower number of heart operations carried out overall, including the number of more urgent elective operations that should normally have been carried out within 30 days [31] .

This review covers a total of 62 publications with highly uneven numbers and types of publications for each question and disease area (Table 1 and Table 2 ). A total of 40 publications were identified exclusively via the additional internet-based search. The remaining 22 sources (including all sources on cancer, 7 of 24 sources on cardiovascular diseases, 2 of 18 on diabetes, and 2 of 9 on mental disorders) were found via PubMed. An additional report by the Scientific Institute of the AOK (WIdO), published shortly after the end of the search period, was nonetheless included, since preliminary results of this analysis had been published in advance during the period covered by the search [17, 18] .

In all disease groups considered, major adjustments to health care availability have taken place (Table 1) . A distinction must be made between, on the one hand, changes to the regulatory framework, such as billing modalities, and, on the other hand, recommendations by medical societies.

In the area of oncology, guidelines prioritising the urgency of surgical cancer treatments were implemented (Table 1 ) in order to ensure that necessary operations could be carried out promptly even when intensive care resources became limited [19, 20] . To segregate patient flows in the health care setting and reduce the risk of infection for cancer patients, it was recommended that treatments be carried out in specialised oncological facilities where possible [20, 21] . Further recommendations involved modifying crisis intervention. For the treatment of physical diseases, follow-up care and check-up appointments as well as tumour conferences have been conducted using telemedicine approaches. These changes were also made possible by expanding billing options to include telemedicine and video consultations [49] . Certain certified video service providers could also be used free of charge in April/May [45] . In psychiatry, new services such as telepsychiatric crisis services, special crisis hotlines or other local services were set up [50] .

The number of hospital admissions of cancer patients insured by the statutory AOK health insurance decreased significantly in the period from mid-March to the beginning of April 2020 (calendar weeks 12 to 14) compared to the same period in the previous year (Table 1 ) [17] . The figures for oncological operations were mixed: for some cancer diagnoses (especially colorectal and lung cancers) the number of primary operations fell by around 20%, while for other diagnoses either no significant decreases or even increases (breast and cervical cancers) were recorded. The number of second operations (breast and colorectal cancers) fell by more than 70% [18] . A survey of nuclear medicine departments and practices, mainly from Germany, concerning cancer and cardiovascular diagnostic and therapeutic procedures also showed a decline in tumour diagnostic procedures of between 14% and 58% (depending on examination type). In contrast, radiation therapy figures for malignant tumours have remained stable [51] . For cardiovascular diseases, the same study showed an overall Routine diabetes care was also curtailed to provide capacity for COVID-19 patients [32, 33] , including the postponement of elective surgical procedures (e.g. kidney transplantation and bariatric surgery) [34] [35] [36] . In addition, the changes made by the Federal Joint Committee (G-BA) to the DMP requirements guideline were particularly important for the treatment of patients with cardiac insufficiency or diabetes. To avoid SARS-CoV-2 infections, patient training sessions, which are normally compulsory parts of the DMP and are usually carried out in a group setting, as well as the documentation of medical examinations by a doctor, were suspended during the first to third quarters of 2020 [37] . In order to ensure that people with diabetes continued to receive training, video training was considered a viable option [32, [38] [39] [40] [41] with some health insurances reimbursing such services [42, 43] . Individual training and consultations remained possible, subject to compliance with hygiene regulations [38] .

Inpatient admissions to psychiatric (day) clinics or rehabilitation facilities were restricted and appointments for treatment postponed. In order to protect mental health care availability for people experiencing acute crises, inpatient services were replaced by outpatient services. Outreach services and treatments were made available to people in need of a high level of support to cope in their daily lives, to those who have difficulty obtaining necessary medication and to those who lack sufficient social support [44] .

Medical societies and professional associations recommended expanding telemedicine services for patients and establishing video consultation hours [20, [45] [46] [47] [48] . Regarding mental health, for example, these recommendations impacted both regular psychotherapeutic treatment and Furthermore, the associations of statutory health insurance physicians and professional associations have reported a reduction in the number of consultations in oncology and cardiology practices, with similar developments being reported in the areas of endocrinology and diabetology [32, 33, [58] [59] [60] [61] [62] . Many professional societies as well as patient organisations urged patients not to neglect the treatment of their chronic disease for fear of infection and, for example, to schedule and attend follow-up and treatment appointments [27, 28, 36, 63] . There were also warnings against independently discontinuing medication such as ACE inhibitors, which are used to treat high blood pressure and were for a while suspected of increasing the risk of a severe course of COVID-19 [64] .

The WIdO institute's analysis of AOK insurance data showed a 49% decrease in inpatient treatment for mental and behavioural disorders during the stricter phases of the lockdown compared to the previous year [65] . The Central Institute of Mental Health in Mannheim recorded a 27% decrease in the use of its emergency service for people with mental health issues, particularly for affective disorders [66] . However, the German Association for Psychiatry, Psychotherapy and Psychosomatics (DGPPN) reported that the 450 psychiatric outpatient clinics in Germany observed an increase in the number of patients from residential and semiresidential care facilities [67] .

So far, very little empirical data exist concerning the impacts on health due to the observed changes to health care decrease in myocardial scintigraphy in outpatients, with a more pronounced trend for hospitals compared to radiological practices [51] . Analyses of AOK insurance data showed a significant decrease in hospital admissions for acute ischemic stroke, myocardial infarction or heart failure in March/April 2020 compared to the corresponding period in the previous year [17] . In a more in-depth analysis, this decrease was particularly marked for mild cases of heart attack and stroke [18] . The same applied to the admission of patients with an abdominal aortic aneurysm [18] . In concordance with these results, decreases in inpatient treatments for heart attack and in acute treatments for heart failure and arrhythmias were reported for the early phase of the pandemic based on data from a second statutory health insurance company (the Deutsche Angestellten Krankenkasse, DAK) and two hospital networks [52] [53] [54] . One university hospital in southern Germany recorded significantly fewer admissions due to minor acute heart attacks -those without changes in the ECG typical of an infarction (NSTEMI) -in March/April 2020 than during the same period in 2017, 2018 and 2019 [55] . The number of admissions due to more severe acute myocardial infarction with ECG changes typical of an infarction (STEMI) did not change, however. Consistently fewer emergency treatments than in previous years were also observed for patients with minor stroke or transient ischaemic attack (TIA). This is shown by analyses of data from 36 regional stroke centres in the Ruhr area [26] and from several stroke units at university hospitals [56] , as well as from the Alfried Krupp Hospital in Essen [26] . In addition, a decline in neurovascular emergencies was also observed at the Charité Berlin during the early phase of the pandemic [57] .

There were no indications that emergency care for stroke and heart attack had been comprised by adjustments to inpatient care capacity in Germany.

Care for the chronically ill in Germany -The challenges during the COVID-19 pandemic FOCUS high-sensitivity troponin T (hsTnT) were measured than in previous years, which may indicate a delayed onset of therapy [55] . The Charité hospital in Berlin also found indications of delayed treatment for patients with chronic subdural haematoma (collection of blood between the outer covering of the brain (dura mater) and the brain) [57] . For example, patients admitted during the early stages of the pandemic showed more severe symptoms and a worse prognosis in the hospital setting [57] .

Various uncertainties were observed among people with diabetes. Patients with diabetes were worried that they might face a higher risk of developing and suffering a severer course of COVID-19 and that they might be infected with SARS-CoV-2 during a doctor's appointment [60] . Patients were afraid of shortages in diabetes medication [71] and reported problems with the contact-free transmission of therapy data to their diabetology practice and uncertainty about how to adjust insulin requirements under changing everyday conditions [72] . The risk of stigmatising people with diabetes as a COVID-19 risk group by excluding them from public life was also discussed [73] .

Our research on the changes to the health care situation for people with selected noncommunicable diseases in Germany during the first months of the COVID-19 pandemic identified only a few empirical studies that were almost exclusively related to inpatient care. The analyses of AOKinsurance data showed a clear decline in inpatient admissions for oncology in March/April 2020 [18] . Other European countries have reported similar declines in hospital service availability and uti lisation. Instead there are pre-dominantly opinions on the feared consequences of delayed diagnosis and therapy, as well as results from surveys of patients and doctors (Table 2) .

Cancer patients often expressed concerns about potentially inadequate or delayed treatment. The possibility of becoming infected and the risk of suffering a severe course of COVID-19 due to cancer or therapy-related immunosuppression have also caused uncertainty [20, 68] . Access restrictions for visitors and accompanying persons of patients in inpatient and outpatient care were considered a burden [68, 69] . In oncological clinical research, there were concerns about delays in recruitment of patients to ongoing clinical therapy trials [20] . These play an important role in providing care to people with rare cancers in particular. A task force formed by the German Cancer Aid, the German Cancer Society and the German Cancer Research Centre (DKFZ) warned of a 'wave' of oncological treatments as a result of the lockdown and changes made necessary by the pandemic [70] .

According to Germany's Association of Cardiologists in Private Practice (BNK), some cardiology patients who cancelled appointments were later treated as emergencies [61] . Furthermore, the German Cardiac Society has also reported an increase in the incidence of complications typical of untreated heart attacks [31] . Based on data from the University Hospital of Ulm, the blood values of heart attack patients, which can provide information about the extent of the organ damage caused, during the early stages of the pandemic were compared with those from the corresponding periods in the years 2017 to 2019 [55] . It was found that in the current year higher average concentrations of Moreover, only a few of the articles identified in the search period discussed outpatient care. According to reports from the National Association of Statutory Health Insurance Physicians (KBV), significantly fewer appointments in oncological and cardiological practices were made during the early stages of the pandemic [61] . An analysis by the Central Research Institute of Ambulatory Health Care in Germany (Zi) has confirmed these observations, but was published outside the review period. According to this analysis, treatment figures in oncological, cardiological, neurological, endocrinological, psychiatric and psychotherapeutic practices fell in the course of March 2020 by up to 40% in the last week of March compared to the same period in the previous year [81] .

Our research identified no results from either quantitative or qualitative studies on the reasons for a delayed utilisation of inpatient or emergency medical treatment in Germany. We were also unable to identify any population-based quantitative or qualitative studies that report whether and why outpatient appointments did not take place (i.e. whether they were cancelled or postponed, either by the doctor's practice due to lack of capacity or by the patients themselves). This question will require further research. Some reports identified by our review indicated that (partial) closures of and limited admissions to hospitals had to be compensated by outpatient services, for example in outpatient cardiology [30] and psychotherapy [82] . Results from ongoing research projects monitoring outpatient care since March 2020, such as COVI-Prim (Accompanying Monitoring of Primary Care in General Practitioners' Practices during the COVID-19 Pandemic), would be important for gaining a deeper insight into the complex admissions and registered cancer diagnoses since mid-February [8, 20, 74, 75] . For cardiovascular diseases, in line with international reports [5, 6, 74, [76] [77] [78] , both AOK data and data from cardiological and neurological clinical departments indicate a decline in the number of patients receiving emergency medical or acute diagnostic care in the same period compared to the previous year [79] . This was associated primarily with a decrease in the number of mild heart attacks and strokes as well as transient ischaemic attacks. According to an analysis of data from 36 emergency departments in Germany, a sharper decrease was likewise observed in less urgent compared to more urgent emergency treatments following implementation of lockdown measures [79] .

In conjunction with some evidence from international studies, this pattern can be interpreted as indicating a substantial role of patients reducing or delaying uti lisation of health care services [18, 26, [55] [56] [57] . An expert report on the effects of the COVID-19 Hospital Relief Act also supports such a hypothesis. In their final report, the members of the committee conclude that a patient's decision to go ahead with treatment or not has played a greater role in explaining the decline in inpatient treatment figures in 2020 compared to the same period last year than hospitals cancelling treatment [80] . For example, in the period from January to May 2020, the proportion of emergency hospital admissions was higher for the first time than the proportion of non-emergency admissions, and the number of less urgent treatments decreased more than more urgent ones [80] . However, our review only identified two empirical studies for Germany indicating a delayed uti lisation of medical care for heart attack and chronic subdural haematoma [55, 57] .

A decrease in hospital admissions for stroke, heart attack and other cardiovascular emergencies has been presumed to be associated with delayed uti lisation of available services.

Care for the chronically ill in Germany -The challenges during the COVID-19 pandemic

Journal of Health Monitoring 2020 5(S10) Journal of Health Monitoring 19 FOCUS not led to critical bottlenecks in oncological care in Germany, and the system has overall been perceived as being relatively adaptable. Probably only a small number of time-critical therapies were postponed. In contrast to European regions with high COVID-19 case numbers, no fundamental restructuring of emergency care for stroke patients in Germany has so far appeared to have occurred [26] . According to the medical societies, the timely diagnosis and treatment of patients with acute cardiovascular events has at no time been at risk [27, 28] . Despite the closure of diabetes units as part of the adaptations of inpatient care capacities in the context of the pandemic [32, 33, 38] , it has been assumed for the time being that the care of diabetes patients could be largely maintained, at least in paediatrics [38] . The health care situation for people with mental disorders cannot yet be fully assessed.

The key question as to the extent to which patients with chronic diseases have suffered damage to their health as a result of pandemic-related changes to health care availability and reduction in uti lisation cannot be answered at present. Our review identified only two empirical studies that found suggestive evidence of delayed utilisation followed by greater disease severity in patients with heart attacks and elderly people with chronic subdural haematoma [55, 57] .

We cannot rule out that delays in diagnostic assessments and follow-up appointments, also due to changes in the utilisation patterns of patients, have led to a shift of diagnosis to later disease stages. Such a shift could lead to poorer treatment outcomes with increases in acute complications or longer-term sequelae [31, 48, 55, 57, 61, 70, 87, 88] . For example, an article published after the literature review requirements that outpatient care providers had to meet, especially in the early stages of the pandemic [81, 83] .

Ongoing analyses of the developments of health care availability and uti lisation in Germany for specific groups of chronically ill persons are important, especially if a new spike in cases were to develop in the course of the pandemic. For example, professional societies in the field of oncology began, at an early stage, to develop a wide range of recommendations to adapt procedures in order to avoid interruptions to diagnostic and therapeutic measures that cannot be postponed while minimising the risk of infection. One potential problem was that a backlog of patients could still develop, partly because older patients in particular may have avoided the health care system, despite symptoms, and thus not have received prompt diagnostics and treatment [20, 70] . Temporary suspension (mammography screening) or reduced uti lisation of cancer screening examinations could also contribute to this.

Encouraged by recommendations from medical societies and associations as well as new billing options, telemedical care services for patients with chronic physical illnesses and mental disorders were expanded. There is great potential for further development of these options beyond the end of the current pandemic [20, 39, 40, 84] . Further analysis is required to determine the extent to which these services are accepted and used by medical professionals and patients. Such analyses should identify barriers to uti lisation due to deficiencies in technical equipment and expertise as well as the inherent limits of such services [72, 85, 86] .

According to the results of surveys, expert assessments and reports from the field, the COVID-19 pandemic has Decreasing outpatient treatments for cancer, cardiovascular disease and diabetes mellitus could have been due to changes in availability and uti lisation of health care services.

Care for the chronically ill in Germany -The challenges during the COVID-19 pandemic

Journal of Health Monitoring 2020 5(S10) Journal of Health Monitoring 20 FOCUS which changes to health care availability and uti lisation related to the pandemic are particularly relevant. The most important limitation is that gaps remain in the review; for example, unpublished results, ongoing work or work in publication were not systematically researched by contacting the relevant institutions. Similarly, as a scoping review, only a categorisation according to type and content of cited sources was conducted, with no evaluation regarding scientific validity. Our searches only covered the period between March and June 2020, meaning that results published outside the search period could not be included in the systematic overview, even if they refer to the period between the beginning of March and mid-June 2020.

In summary, during the early stages of the COVID-19 pandemic the number of people treated for cancer, cardiovascular diseases, diabetes mellitus and mental disorders decreased in Germany. In order to learn from this for future crises, the roles played by changes to health care availability and declines in uti lisation will require further clarification. In order to make necessary adjustments quickly, it will be important to continue monitoring the health care situation throughout the ongoing course of the pandemic. Only a targeted monitoring of the developments in outpatient and inpatient care can shed light on adverse and possibly long-term consequences for patient's health and well-being due to changes in the health care situation. At the population level, the close monitoring of the development of cause-specific morbidity and mortality will require a reliable, timely and continuously available data basis. period showed that the frequency of diabetic ketoacidoses in children and adolescents with newly diagnosed type 1 diabetes was higher during the early stages of the pandemic than in the comparable period of previous years, which could be due to a delay in diagnosis [87] . As a result of the COVID-19 pandemic, experts expect an increase in mental disorders such as adjustment disorders, anxiety disorders, depression and trauma disorders [89] to which the health care system will have to respond in the longer term. Based on past experiences, the German Association for Psychiatry, Psychotherapy and Psychosomatics also points out that increased suicide rates must be anticipated, especially if the economic downturn caused by the pandemic continues to worsen [90] .

In summary, these results show a considerable need for research both on the causes and the consequences of changes to the availability and uti lisation of health care services by chronically ill people in Germany.

One of the strengths of the present review is that it included not only a structured search in PubMed but also additional searches via the search engines Google and Google Scholar as well as the websites of selected organisations. The expanded search enabled us to identify the vast majority of contributions, including important reports from the WIdO institute on changes in hospital case numbers in March/April 2020 as well as opinions, recommendations for action and information from medical societies and professional organisations. In addition, the searches were specifically targeted at four common noncommunicable disease groups for

Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe

Coronavirus: Krankenhäuser verschieben planbare Eingriffe

Chouihed T (2020) Collateral damage of the COVID-19 outbreak: expression of concern

Decline of acute coronary syndrome admissions in Austria since the outbreak of COVID-19: the pandemic response causes cardiac collateral damage

COVID-19: A&E visits in England fall by 25% in week after lockdown

Emergency ambulance services for heart attack and stroke during UK's COVID-19 lockdown

Delayed access or provision of care in Italy resulting from fear of COVID-19

Fewer cancer diagnoses during the COVID-19 epidemic in the Netherlands

World Health Organization (WHO) (2020) Rapid assessment of service delivery for NCDs during the COVID-19 pandemic

Association of Cancer with Risk and Mortality of COVID-19: Results from the UK Biobank

COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study

Aktualisierte Stellungnahme: Auswirkungen der SARS-CoV-2-Pandemie auf die Versorgung zerebrovaskulärer Erkrankungen

Capacity changes in German certified chest pain units during COVID-19 outbreak response

Stroke care during the COVID-19 pandemic: experience from three large European countries

DGK) (2020) Offener Brief an BMBF-Ministerin Karliczek

Auswirkungen der SARS-CoV-2-Pandemie auf die Versorgung zerebrovaskulärer Erkrankungen

DGK) (2020) In Sorge um unsere Patienten: der Wunsch nach einem Pragmatismus mit Plan!

Herzkranke in Corona-Zeiten vielfach gefährdet

Die indirekten Schäden der Corona-Pandemie. WeltN24 GmbH

Häufigkeiten von Vorerkrankungen mit erhöhtem Risiko für einen schwerwiegenden klinischen Verlauf von COVID-19 -Eine Analyse kleinräumiger Risikoprofile in der deutschen Bevölkerung. Versorgungsatlas-Bericht Nr 20/05. Zentralinstitut für die kassenärztliche Versorgung in Deutschland (Zi)

Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort

Scoping studies: towards a methodological framework

Providing actionable evidence in Public Health -The 2018 international workshop on evidence-based public health at the Robert Koch Institute

Taking stock of existing evidence and closing evidence gaps -Reflections from the National Institute for Health and Care Excellence (NICE)

Wissenschaftliches Institut der AOK (WIdO) (2020) Erste Ergebnisse aus den Auswertungen zu COVID-19-Patienten: Unter Nutzung der tagesaktuellen AOK-Abrechnungsdaten nach §301 SGB V

Entwicklung der Krankenhausfallzahlen während des Coronavirus-Lockdowns. Nach ICD-Diagnosekapiteln und ausgewählten Behandlungsanlässen. Wissenschaftliches Institut der AOK (WIdO) Berlin

COVID-19-Leitfaden für die Priorisierung von Operationen bei malignen thorakalen Erkrankungen

Deutsche Diabetes Gesellschaft (DDG) (2020) Praktische Empfehlungen zum Diabetes-Management bei Patientinnen und Patienten mit einer COVID-19-Erkrankung

Und plötzlich geht immer mehr per Video

Auch für die GOÄ gibt es nun Sonderregeln

Psychiatrische Versorgung während der COVID-19-Pandemie

Neue Optionen unter COVID-19 -Videosprechstunde und anderes…

DGK) (2020) Versorgung trotz COVID-19 -Telemedizin ausbauen wo immer es geht

2020) Versorgung sicherstellen, Patienten schützen und Existenz sichern: Wichtige Informationen für die Vertragsärzte während der Coronakrise

Implications of SARS-CoV-2 Infection and COVID-19 Crisis on Clinical Cancer Care: Report of the University Cancer Center Hamburg

Beschluss Sonderregelungen aufgrund der COVID-19-Pandemie vom 27

Bundespsychotherapeutenkammer (BPtK) (2020) BPtK-Wegweiser für psychisch kranke Menschen in der Coronakrise

Diabetes News Media AG (2020) Corona zeigt deutlich den Bedarf nach Telemedizin

2020) Diabetesversorgung durch Corona-Pandemie gefährdet. DDG warnt vor drohender Unterversorgung von chronisch und akut Erkrankten

Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery

Deutsche Gesellschaft für Innere Medizin e. V. (DGIM) (2020) Mindestmengen-Regelung für Nierentransplantationenaussetzen. DGIM: Versorgung der Risikogruppe "Nierenpatient" während und nach Corona gewährleisten

Practical recommendations for the management of diabetes in patients with COVID-19

Änderung der DMP-Anforderungen-Richtlinie (DMP-A-RL): Ausnahmeregelungen für Schulungen und Dokumentationen aufgrund der COVID-19-Pandemie vom 27

Challenges in the Care of Children and Youth With Diabetes in Times of the Corona Pandemic: Personal View of the Situation in a German Clinic

Time for a Change: Personal Experiences With COVID-19 and Diabetes

COVID-19, type 1 diabetes, and technology: why paediatric patients are leading the way

Care for the chronically ill in Germany -The challenges during the COVID-19 pandemic

2020) Revitalisierung der ambulanten Versorgung in Bayern

DHS) (2020) Corona-Pandemie und Herznotfälle: Bei Herzinfarkt-Verdacht keine Scheu vor dem Notruf 112

DHS) (2020) Herzmedikamente wie ACE-Hemmer und Sartane auf keinen Fall wegen des Coronavirus absetzen!

Wissenschaftliches Institut der AOK (WIdO) (2020) Starker Rückgang der Krankenhaus-Fallzahlen durch Coronavirus-Lockdown bei planbaren Eingriffen, aber auch bei Notfällen

Decreased utilization of mental health emergency service during the COVID-19 pandemic

Psychosomatik und Nervenheilkunde e. V. (DGPPN) (2020) Corona: Psychiatrie und Psychotherapie leisten Maximales

Oncology services in corona times: a flash interview among German cancer patients and their physicians

Caring for older patients with cancer during the COVID-19 pandemic: A Young International Society of Geriatric Oncology (SIOG) global perspective

Deutsches Krebsforschungszentrum (DKFZ) (2020) Onkologische Versorgung während der COVID-19-Pandemie: Warnung vor einer Bugwelle an zu spät diagnostizierten Krebsfällen

Impact of COVID-19 on Nuclear Medicine in Germany, Austria and Switzerland: An International Survey in

Deutlich weniger Herzinfarktpatienten in Asklepios Kliniken

Emergency hospital admissions and interventional treatments for heart failure and cardiac arrhythmias in Germany during the COVID-19 outbreak: insights from the German-wide Helios hospital network

2020) Herzinfarkt: Deutlich weniger Krankenhauseinweisungen im März

days of COVID-19-cardiac events during restriction of public life-a comparative study

Acute Stroke in Times of the COVID-19 Pandemic: A Multicenter Study

Need for ensuring care for neuro-emergencies-lessons learned from the COVID-19 pandemic

Diabetiker in Corona-Krise nicht vergessen

Nationale Diabetesstrategie in der neuen Corona-Normalität. www.diabetesstimme.de appelliert an die Politik

Weniger Besuche bei Fachärzten

Care for the chronically ill in Germany -The challenges during the COVID-19 pandemic

Veränderung der vertragsärztlichen Leistungsinanspruchnahme während der COVID-Krise Tabellarischer Trendreport für das 1. Quartal 202.1-68. Zentralinstitut für die kassenärztliche Versorgung in Deutschland (Zi)

Psychosomatik und Nervenheilkunde e. V. (DGPPN) (2020) Pandemie und Psyche

Zentralinstitut für die kassenärztliche Versorgung (Zi) (2020) Anforderungen an die Organisation der ambulanten hausärztlichen Versorgung während der COVID-19-Pandemie

DGK) (2020) Echokardiografie in Zeiten von COVID-19

Application and Effectiveness of Telehealth to Support Severe Mental Illness Management: Systematic Review

The Current State Of Telehealth Evidence: A Rapid Review

Ketoacidosis in Children and Adolescents With Newly Diagnosed Type 1

Diabetes During the COVID-19 Pandemic in Germany

Rückkehr zur Regelversorgung: Chronische Krankheiten machen keine Coronapause

COVID-19-Pandemie: Psychische Störungen werden zunehmen

Junge Menschen mit Diabetes mellitus ohne Folgeerkrankungen gehören nicht zur Risikogruppe für COVID-19

2020) Menschen mit Diabetes sind nicht grundsätzlich COVID-19-Risikopatienten: DDG warnt vor Stigmatisierung von Bevölkerungsgruppen während der Corona-Pandemie

Reduced Rate of Hospital Admissions for ACS during COVID-19 Outbreak in Northern Italy

COVID-19 in Europe: the Italian lesson

Reduction in ST-Segment Elevation Cardiac Catheterization Laboratory Activations in the United States During COVID-19 Pandemic

Admission of patients with STEMI since the outbreak of the COVID-19 pandemic. A survey by the European Society of Cardiology

The COVID-19 Pandemic and Acute Aortic Dissections in New York: A Matter of Public Health

Medical Emergencies During the COVID-19 Pandemic

Abschlussbericht zur Überprüfung der Auswirkungen der Regelungen in den § § 21 bis 23 auf die wirtschaftliche Lage der Krankenhäuser durch den Beirat gemäß § 24 Krankenhausfinanzierungsgesetz

Care for the chronically ill in Germany -The challenges during the COVID-19 pandemic

Psychosomatik und Nervenheilkunde e. V. (DGPPN) (2020) Suizidprävention: in Krisenzeiten besonders wichtig

Nuclear Medicine Operations in the Times of COVID-19: Strategies, Precautions, and Experiences

Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e. V. (DGHO) (2020) Society Bulletins

DGN) (2020) Es muss sichergestellt werden, dass alle Patienten die für sie notwendigen Behandlungen erhalten

Diabetes News Media AG (2020) Versorgung mit Hilfsmitteln in der Coronakrise

Nationale Kontakt-und Informationsstelle zur Anregung und Unterstützung von Selbsthilfegruppen (NAKOS) (2020) Selbsthilfe und Corona

Bundespsychotherapeutenkammer (BPtK) (2020) Trotz Corona -Psychotherapeut*innen weiter erreichbar

DGPs) (2020) Stellungnahme zur Notwendigkeit der Notbetreuung von psychisch kranken Kindern und Kindern von psychisch kranken Eltern in Kindertagesstätten und Schulen während der Coronakrise

We would like to thank Denise Ducks for her support in the synthesis of literature.