key: cord-0971692-ezzcgy6z
authors: Musa, Saif A.; Sivaramakrishnan, Anand; Paget, Stephanie; El-Mugamar, Husam
title: COVID-19: Defining an invisible enemy within healthcare and the community
date: 2020-06-08
journal: Infection control and hospital epidemiology
DOI: 10.1017/ice.2020.283
sha: 33498d54efdc554fe7a1c55389224dd0af302daf
doc_id: 971692
cord_uid: ezzcgy6z

nan

To the Editor-The rapid dissemination of severe respiratory coronavirus virus 2 (SARS-CoV-2) throughout the globe has been declared a pandemic. A lack of national and internationally agreed case definitions for healthcare-associated coronavirus disease 2019 (COVID-19) has led to inconsistencies in describing epidemiology, which limit comparisons. 1,2 A median incubation period of 5 (range, 1-14) days has been accepted in COVID-19 guidance. 3 Adapting established case definitions from other infectious diseases, such as Clostridium difficile infection (CDI), may help overcome variability. 4 All cases with a positive nasopharyngeal real-time polymerase chain reaction (PCR) assay would therefore be described as either healthcare associated (HA) or community associated (CA).

Hospital-onset healthcare-associated (HoHA) COVID-19 would define current hospitalized inpatients residing >14 days. Hospitalonset possible healthcare-associated (HoPHA) cases, in those residing between 3 and 14 days in the hospital, in the absence of suspected COVID-19 on admission. New cases diagnosed within 14 days of acute-care hospital discharge would be community-onset, healthcare-associated (CoHA) infection. Community-associated (CA) cases would refer to those diagnosed within 2 days or suspected on admission (diagnosed >2 days after admission) and no acute-care hospitalization within the previous 14 days. This group can be further subdivided into those who are independent and self-caring from their own home (CoCA) or those requiring social care, that is, social-onset community-associated (SoCA). Social care includes those requiring domiciliary care (including visiting home care, extra care housing and live in homecare), admissions from care homes, community rehabilitation, and mental healthcare institutions.

We retrospectively applied these definitions to 631 adult COVID-19-positive patients (aged >16 years) at our acute-care institution in North London from March 1, 2020, to April 15, 2020 inclusive. The study was registered with our local clinical governance committee. Because all care was routine, in keeping with UK national guidance, ethical approval was not required. In total, HoHA, HoPHA, and CoHA cases accounted for 80 of 631 (12.68%) of all positive cases (Fig. 1) . The rates of HoHA and HoPHA COVID-19 cases per total number of hospital admissions during this period were 32 of 1,818 (1.76%) and 32 of 1,818 (1.76%), respectively. Median diagnosis occurred 25 days (IQR, 21-43) after admission for HoHA COVID-19 and 9 days (IQR, 6-11) after admission for HoPHA COVID-19, respectively. For CoHA, 16 of 631 patients (2.54%) presented a median of 8 days (IQR, 2-11) after hospital discharge. Median diagnosis of CA cases occurred 1 day (IQR, 1-2) after testing.

Recent NHS England guidance recommends screening all emergency hospital admissions on admission followed by a single repeat, for those testing negative, between 5 and 7 days after admission. 5 Our data demonstrate that healthcare-associated COVID-19 has contributed an important number of cases patients during the height of a pandemic. Sequential screening of non-COVID-19 hospitalized patients beyond this, possibly on a weekly basis up to 14 days after hospital discharge, may prove beneficial in further reducing the threat posed by SARS-CoV-2. Further validation of proposed definitions is required and according to the evolution of CDI definitions, amendments are likely. 

Prevention of nosocomial COVID-19: another challenge of the pandemic

Fast nosocomial spread of SARS-CoV2 in a French geriatric unit Lyon Study Group on COVID-19 infection

COVID-19: infection prevention and control guidance

Clostridium difficile infection objectives for NHS organisations in 2019/20 and guidance on the intention to review financial sanctions and sampling rates from 2020/21 improvement. National Health Service England and National Health Improvement website

Operating framework for urgent and planned services in hospital settings during COVID-19. National Health Service England and National Health Improvement website

Algorithm describing COVID 19 cases presenting at our institution from

Financial support. No financial support was provided relevant to this article.

All authors report no conflicts of interest relevant to this article.