key: cord-0969471-1qlqhrf9 authors: Huang, Xiaoyi; Wei, Fengxiang; Yang, Ziqing; Li, Min; Liu, Liuhong; Chen, Ken title: Lactose Dehydrogenase in Patients with Severe COVID-19: A Meta-Analysis of Retrospective Study date: 2020-04-24 journal: Prehospital and disaster medicine DOI: 10.1017/s1049023x20000576 sha: bd4aa2fa1c75da6088a5075abedde1d29f1f5ead doc_id: 969471 cord_uid: 1qlqhrf9 nan continuous LAC measurements may play a role in predicting the evolution of more severe disease forms. The evidence makes a plausible explanation. The increase of LAC in severe patients is more obvious than that in normal patients, which may be linked to the inflammatory response. The sharp and sudden rise of LAC accompanied by respiratory failure often indicates the acute inflammatory response storm and indicates the disease progression. The LAC test is not widely used in clinical tests. The LAC in the body mainly comes from the results of anaerobic fermentation of glucose by red blood cells and tissue cells. Glucose is paralyzed by a series of enzymes to form pyruvate, which is then catalyzed by LAC to form LAC, which is circulated through the blood to the liver and converted into glucose via gluconeogenesis. Severe hypoxia, strenuous exercise, and severe liver disease all lead to the increase of LAC level. 12 Changes in LAC levels in COVID-19 patients can reflect the body's hypoxia state. In hospitals where blood and gas analysis cannot be conducted, LAC measurement can indirectly reflect the body's respiratory function and also reflect the degree of metabolic acidosis in the body. 13 Patients with COVID-19 showed mild or normal symptoms after onset and were discharged after treatment. 14 However, with the development of the disease, some patients become severe or critical, with dyspnea and hypoxemia, and progress to acute respiratory distress syndrome (ARDS) and severe metabolic acidosis, which can lead to death. 15 Due to the complexity of severe patients and emerging infectious diseases, it is inevitable that there are errors or deficiencies which require more and more in-depth research in many aspects, as well as the joint efforts of multiple disciplines such as epidemiological investigation, clinical medicine, pathology, laboratory medicine, and pharmacology. 16 Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study COVID-19: a critical care perspective informed by lessons learnt from other viral epidemics Clinical features of patients infected with 2019 novel coronavirus in Wuhan Coronavirus disease 2019 (COVID-19) and pregnancy: what obstetricians need to know World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19) Novel coronavirus is putting the whole world on alert Going global -travel and the 2019 novel coronavirus Estimating the mean and variance from the median, range, and the size of a sample Clinical features of patients infected with the 2019 novel coronavirus (COVID-19 Clinical characteristics of coronavirus disease 2019 in China Epidemiological and clinical features of 2019-nCoV acute respiratory disease cases in Chongqing municipality, China: a retrospective, descriptive, multiple-center study. medRxiv A novel coronavirus (2019-nCoV) causing pneumoniaassociated respiratory syndrome A pneumonia outbreak associated with a new coronavirus of probable bat origin Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study COVID-19: not a simple public health emergency