key: cord-0966023-k3h03gck authors: Jouffroy, Romain; Darmon, Michael; Isnard, Foucauld; Geri, Guillaume; Beurton, Alexandra; Fartoukh, Muriel; Tudesq, Jean-Jacques; Nemlaghi, Safaa; Demoule, Alexandre; Azoulay, Elie; Vieillard-Baron, Antoine title: Impact of prone position in non-intubated spontaneously breathing patients admitted to the ICU for severe acute respiratory failure due to COVID-19 date: 2021-05-01 journal: J Crit Care DOI: 10.1016/j.jcrc.2021.04.014 sha: f7e0fc9d946f8ea6ad0910d5f508fe90099e503b doc_id: 966023 cord_uid: k3h03gck PURPOSE: Studies performed in spontaneously breathing patients with mild to moderate respiratory failure suggested that prone position (PP) in COVID-19 could be beneficial. MATERIALS AND METHODS: Consecutive critically ill patients with COVID-19 were enrolled in four ICUs. PP sessions lasted at least 3 h each and were performed twice daily. A Cox proportional hazard model identified factors associated with the need of intubation. A propensity score overlap weighting analysis was performed to assess the association between spontaneous breathing PP (SBPP) and intubation. RESULTS: Among 379 patients, 40 underwent SBPP. Oxygenation was achieved by high flow nasal canula in all but three patients. Duration of proning was 2.5 [1.6;3.4] days. SBPP was well tolerated hemodynamically, increased PaO(2)/FiO(2) (78 [68;96] versus 63 [53;77] mm Hg, p = 0.004) and PaCO(2) (38 [34;43] versus 35 [32;38] mm Hg, p = 0.005). Neither day-28 survival (HR 0.51, 95% CI 0.16–1.16] nor risk of invasive ventilation [sHR 0.96; 95% CI 0.49;1.88] differed between patients who underwent PP and others. CONCLUSIONS: SBPP in COVID-19 is feasible and well tolerated in severely hypoxemic patients. It did not induce any effect on risk of intubation and day-28 mortality. The COVID-19 pandemic has led to a massive influx of patients in intensive care units (ICUs) [1] , as severe forms have been frequently reported, including acute respiratory distress syndrome (ARDS) [2, 3] . In a large series of patients hospitalized for severe ARDS was reported to be the cause of death in 98% of cases [4] . In the context of potential ventilator shortage, and based on the characteristics of this specific ARDS [5] , limiting mechanical ventilation to only patients with obvious clinical indications in order to avoid complications of mechanical ventilation was proposed [6, 7] . COVID-19 patients tolerate profound hypoxemia well with a rate of invasive ventilation worldwide ranging from 29 to 90% [8] . Recent single-centre studies have suggested the feasibility of prone position (PP) in spontaneously breathing COVID-19 patients with acute respiratory failure and its ability to increase oxygenation, resulting in clinical improvement [9] [10] [11] [12] [13] . However, these studies were performed in selected patients with mild to moderate decrease in oxygenation, most of them being hospitalized outside the ICU and treated with positive airway pressure. Before large implementation, more studies evaluating the impact of such a strategy on the outcome are required [14] . Ferrando et al. recently reported that PP did not affect the need for intubation [15] , while this remains to be confirmed. We sought to report prevalence PP in spontaneously breathing critically ill COVID-19 patients -with severe acute respiratory failure, as well as its impact on outcomes. J o u r n a l P r e -p r o o f Journal Pre-proof Methods This retrospective observational study was performed in four university-affiliated hospitals in Paris [3] . All consecutive patients with laboratory-confirmed SARS-CoV-2 infection admitted to one of the ICUs between February 20 and April 24, 2020 were enrolled. The appropriate IRB approved this study and, due to the nature of retrospective chart review, waived the need for informed consent from individual patients. Laboratory confirmation of SARS-Cov-2 was defined as a positive result of real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay of nasal and pharyngeal swabs. The four participating ICUs applied Parisian guidelines regarding the provision of standard of care, the use of non-invasive ventilation, antibiotic treatment, as well as the use of rescue therapy as ECMO. All mechanically ventilated patients had a protective lung approach. These guidelines were approved by all and shared on the Health Regional Agency website (https://www.iledefrance.ars.fr/coronavirus-covid-19-information-aux-professionnels-desante). There were no guidelines regarding the use of anti-viral agents, steroids, or cytokineblockade that were mostly used in RCTs. Prone position in spontaneously breathing patients was protocolized including at least twice daily physiotherapy. It was left to the discretion of the attending physician when it was expected as potentially useful, as well as the decision to move to intubation, mainly based on clinical status as respiratory exhaustion, encephalopathy, need to start or to increase vasopressors, and rejection by patients to continue proning. thereby allowing calculation of the interval between symptom onset and admission to the ICU. SOFA score [16] was recorded, as were the need for vasopressors, the serum lactate level, the presence of acute kidney injury at admission [17] , the need for renal replacement therapy, and the main laboratory findings. PaO 2 /FiO 2 and respiratory rate (RR) were collected, as were the modalities of oxygenation in spontaneously breathing patients: noninvasive ventilation (NIV), continuous positive airway pressure (CPAP), high-flow nasal cannula (HFNC) and conventional low flow devices (nasal cannula, simple face mask). Need for intubation until day 28, ICU discharge and day-28 mortality were evaluated. We recorded the duration in days of the PP strategy. In the spontaneous breathing PP (SBPP) group, PP session lasted between 3 and 6 hours and was performed twice a day when possible. PP tolerance was evaluated by reporting respiratory rate (RR), mean arterial pressure (MAP), heart rate (HR) and serum lactate before and at the end of the first proning session, just before resupination. FiO 2 , PaO 2 /FiO 2 , PaCO 2 , and pH were reported before the first proning session and at the end of the last proning session. Quantitative variables were described as median (interquartile range [IQR] ) and were compared between groups using the non-parametric Wilcoxon rank-sum test. Qualitative variables were described as frequency (percentages) and were compared between groups using Fisher"s exact test. Factors associated with day-28 mortality were assessed using survival analysis. Risk of invasive ventilation was assessed using a time-dependent Cox model and competing risk cumulative incidence analysis taking into account competing risk of mortality and discharge alive from the ICU. Data are reported as hazard ratios (HR; 95% CI) or sub-hazard ratios J o u r n a l P r e -p r o o f Journal Pre-proof (sHR; 95% CI) according to the model used. Adjustment for a centre effect was assessed using frailty models. Then propensity score weighting analysis was performed to assess the association between SBPP and the outcome of interest. Briefly, variables associated with SBPP and believed to have influenced its choice were entered in a propensity score overlap weighting. This strategy allows weighting of patients from each treatment group by the probability of being assigned the other treatment group [18] . This allows higher weight to be assigned to patients with intermediate risk and lower weight to outliers in both treatment groups, the analysis emphasizing the proportion of the population where the most treatment equipoise exists in clinical practice [19] . Covariates included in the model were centre, underlying immune defect, history of hypertension, underlying chronic kidney disease, interval between onset of symptoms and ICU admission, SOFA score, acute kidney injury, need for vasopressors and PaO 2 /FiO 2 at ICU admission, and use of HFNC as oxygenation modality at day 1. Quality of matching was assessed using propensity score distribution before and after matching and standardized mean difference of variables of interest before and after matching. The influence of SBPP on mortality and risk of invasive ventilation was assessed using survival analyses as previously described. Statistical analyses were performed using R version 3.6.2 (R Foundation for Statistical Computing), "survival"," cmprisk" and "WeightIt" and "Survey" packages and statistical significance was considered using two-sided tests with a critical alpha risk of 0.05. Of 379 consecutive patients included, 40 (10.5%) underwent SBPP (Figure 1) . Figure 2 ), increased PaO 2 /FiO 2 (p = 0.004) and PaCO 2 (p = 0.005) (Table 3, Figure 2 ). "Do not intubate" decision was negligible in the whole cohort, as 12 patients died without intubation, 1 (2.5%) in the SBPP group and 11 (3.2%) in the non-SBPP group. Twenty-three patients (58%) in the SBPP group were discharged alive without any intubation, while 16 (40%) required invasive ventilation, all within 10 days. One patient died without invasive ventilation. After adjustment for centre, SBPP was associated with increased day-28 survival ( Figure S1, (Table S1 ). The fact that median PaO 2 /FiO 2 was 63 mmHg at the time of proning highlights that our patients not only were critically ill, but also presented pictures of severe ARDS. It is somewhat questionable that patients with such low PaO 2 /FiO 2 were not considered for a quick escalation of respiratory support. While it is considered to be specific to COVID-19 patients to well-tolerated profound hypoxemia [6, 20] , this respiratory strategy has been actually proposed much before the pandemic by Scaravelli et al. in 15 non-COVID patients with "usual" severe respiratory failure, in whom mean PaO 2 /FiO 2 before proning was around 120 mmHg [21] . Previous studies in COVID-19 suggested the potential value of prone position in awake patients, but they were performed in selected patients with mild to moderate respiratory failure, outside the ICU, and, in 2 of the studies, in patients treated with positive pressure ventilation [9] [10] [11] [12] . Elharrar et al. enrolled 24 patients; PaO 2 /FiO 2 was not given, but mean PaO 2 before proning was 73 mmHg with an oxygen delivery below 4 L/min in most patients [9] . Sartini et al. enrolled 15 patients, all non-invasively ventilated [10] . Thomson et al. reported in 25 patients admitted that PP increased oxygenation, but that almost half of the patients finally required intubation, especially among those who did not have oxygen respiratory failure. We were able to compare survival and the risk of invasive ventilation between patients with and without the SBPP strategy, and not between responders and nonresponders to proning, which adds new information on the potential impact of PP in a population of spontaneously breathing COVID-19 patients without any assistance. Interestingly, 58% of our patients in the SBPP group were discharged alive without intubation. Ferrando Besides the absence of association with intubation and survival, patient"s safety and oxygenation benefits, namely, increase in PaCO 2 , an improvement in oxygenation and no increase in RR could also suggest that SBPP did alleviate self-inflicted lung injury. We were however unable to report changes in respiratory compliance in the 16 patients who secondarily required intubation. We also recently reported that oxygen delivery in spontaneously breathing patients using HFNC was able to prevent intubation [22] , which also does not support such an injury. However, early intubation and "preemptive mechanical ventilation" to avoid self-inflicted lung injury remains controversial until trials will appropriately assess this hypothesis [6] . Ferrando et al. also reported that prone position in awake patient could induce delay in intubation, while they did not report any impact on day- Our study has some limitations. First, its retrospective design did not allow a definitive conclusion to be drawn. However, as discussed, patients were not a priori selected for PP, while most of them had single organ failure with lower Sofa score, less acute kidney injury and a lower number of patients with vasopressors. By using adequate statistical analysis with a propensity score, we tried to soften this limitation and especially the absence of a randomized control group and our adjustment between the 2 groups was very good. Journal Pre-proof Moreover, we did not differentiate patients according to predictors of response to proning, as CT-scan or lung ultrasonography. Second, although we report one of the largest series of patients, the sample size was relatively small and a lack of power is not excluded. Another explanation for the absence of impact on outcomes could be related to limited time of patients" exposure to proning. However, in their small observational study, Scaravilli et al. reported that most patients were discharged alive from hospital without intubation and the exposition was also limited with a median duration of proning of 3 hours and a mean number of sessions per patient of 2 [21] . Despite low exposition, SBPP could avoid or delay intubation and well-known deleterious effects of positive pressure ventilation [6] , especially during the pro-inflammatory process following the admission in the ICU. A recent study which performed a clustering in critically-ill COVID-19 patients based on their inflammatory status reported that patients with high interleukine-6 at ICU admission had the highest requirement to intubation and the highest mortality [23] . How SBPP could be useful in this subgroup of patients could be evaluated. Third, we did not differentiate responders and nonresponders to SBPP and then to evaluate whether their outcome could be different. However, this is also one of the strengths of our study as we evaluated a global strategy which is to delay intubation when possible thanks to use of SBPP. Moreover, previous studies have reported that oxygenation improvement (responders) was usually transient and not maintained [9] [10] [11] [12] . We also acknowledge that increase in PaO 2 /FiO 2 after proning was probably clinically non-relevant, while statistically significant. However, it was well-demonstrated in ARDS that improvement in gas exchange by prone position did not predict and explain improved survival [24] . We report that SBPP was used in around 10% of patients admitted in the ICU for severe respiratory failure and was well-tolerated. After adjusting for confounders, we did not demonstrate any association with intubation and day-28 mortality rates. Randomized controlled trials to assess clinical benefits associated with SBPP are warranted. The following are the supplementary data related to this article. The appropriate IRB approved this study and, due to the nature of retrospective chart review, waived the need for informed consent from individual patients. GG declares non-financial support from Bard. JJT declares non-financial support from Pfizer and personal fees from MSD. MD declares grant from MSD and personal fees from MSD, Astellas and Gilead. AVB declares grant from GSK. The other authors did not declare any conflict of interest. Funding: no funding. Authors 'contribution: AVB and RJ designed the study and wrote the manuscript, EA read and corrected the manuscript, MD did the statistical analysis, RJ, FI, GG, AB, MF, JJT, SM and AD included patients, read and accepted the manuscript. J o u r n a l P r e -p r o o f Panel A regards changes in blood gas and FiO 2 after the last proning session. Panel B regards clinical tolerance after the first session, just before resupination. 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AVB and RJ designed the study and wrote the manuscript, EA read and corrected the manuscript, MD did the statistical analysis, RJ, FI, GG, AB, MF, JJT, SM and AD included patients, read and accepted the manuscript.Authors declare no conflict of interest in relation with this manuscript.