key: cord-0963920-t383vln8
authors: Henry, Brandon Michael; Benoit, Stefanie; Lippi, Giuseppe; Benoit, Justin
title: Circulating plasma levels of angiotensin II and aldosterone in patients with coronavirus disease 2019 (COVID-19): A preliminary report
date: 2020-07-10
journal: Prog Cardiovasc Dis
DOI: 10.1016/j.pcad.2020.07.006
sha: 682177a1ca623a2cbdabc9e8f20833b131a7a1c9
doc_id: 963920
cord_uid: t383vln8

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J o u r n a l P r e -p r o o f PCR) test for COVID-19 via a standard-of-care nasopharyngeal swab. Patients taking medications targeting the RAAS, such as ACE inhibitors and angiotensin receptor blockers, were excluded. Deidentified samples from healthy, normotensive outpatient adults were used as controls. Plasma concentration of AngII was measured using ELISA (Enzo Life Sciences, Farmingdale, NY, USA). Plasma concentration of aldosterone was measured using Diasorin Liaison XL (DiaSorin S.p.A. Saluggia, Italy).

COVID-19 positive patients were stratified into subgroups based on ED disposition (hospitalized vs. discharged) and need for intensive care unit admission (ICU vs. no ICU).

Comparisons of plasma concentrations of AngII and aldosterone was performed using the Mann-Whitney U test. The relationship between AngII and aldosterone was evaluated using the Spearman's rho. Ang II concentrations were similar between COVID-19 patients requiring ICU admission vs.

those not requiring ICU admission (D). Ang II levels significantly correlated with aldosterone levels in the COVID-19 cohort (p=0.03) (E).

Angiotensin-Converting Enzyme 2 and Anti-Hypertensives (Angiotensin Receptor Blockers and Angiotensin Converting Enzyme Inhibitors) in Coronavirus Disease 2019 (COVID-19)

Clinical Characteristics of Covid-19 in China

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

COVID-19, ACE2, and the cardiovascular consequences