key: cord-0963110-822aq4l9
authors: nan
title: P5‐90: Association of persistent and delayed symptoms with pneumonia in COVID‐19
date: 2021-11-19
journal: Respirology
DOI: 10.1111/resp.14150_297
sha: dba9d20d41e09ea1c894dfa0cf1651a9184157fd
doc_id: 963110
cord_uid: 822aq4l9

nan

Background: The immune response in COVID-19 has some characteristic features which are unlike other viral fevers. Some post COVID-19 symptoms are prevalent even after the patients are discharged. A rise in CRP levels is associated with an increase in the disease severity of COVID-19. Inflammatory markers have been found to be raised even after patients tested RT-PCR negative for COVID-19. The aim of this study was to evaluate CRP levels in post COVID-19 geriatric patients. Methods: 90 adult patients, above 60 years of age, with diagnosed COVID-19 disease, were studied in a tertiary health care center in New Delhi, India. In this study, the follow-up was follow-up visit was done within 6 weeks. The serum levels of CRP were measured by immunoturbidimetry. High-Resolution Computed Tomography (HRCT) Scanning was done for all patients during the course of the disease and they were classified into mild (n=30), moderate(n=30) and severe (n=30) groups based on the scoring. Data is presented as MeanAES.D. and relationships were determined by Pearson correlations. Results: The mean age of the patients was 64AE3 (mild), 62AE4 (moderate), 65AE3 (severe) years COVID-19. The mean serum CRP levels [29.6AE3.7 mg/l] for severe and moderate [24.3AE4.8 mg/l] post COVID-19 patients were significantly higher than mild post COVID-19 cases [16.5AE4.1 mg/l] [p<0.01]. Higher CRP values post COVID-19 correlated with a higher HRCT score. Conclusion: Our results suggest that inflammatory marker CRP should be evaluated in patients recovering from COVID -19 as a part of their follow-up program in order to track the recovery of patients.

Sakuo Hoshi 1 1 Infection Control Team, Koto Hospital, Japan

Background and Aims: Covid-19 develops flu-like symptoms, so it is very important to screen Covid-19 suspicious patients. We have made a Covid-19 questionnaire since Feb. 20, 2020. We have evaluated the effectiveness of our Covid-19 questionnaires. Methods: The first version questionnaire has been made on Feb.20, 2020. The questionnaire has been revised 5 times according to the change of a Covid-19 epidemic. Items of the questionnaire were composed of symptoms such as fever and impaired sense of taste and smell, travels within 2 weeks, close contact with Covid-19 patients and so on. We asked more than 1000 patients on the basis of the questionnaire. We set criteria to diagnose if a patient suffered Covid-19. We did a SARSCoV-2 nucleic acid amplification test to 481 patients actually. We examined if questionnaire positive patients were SARSCoV-2 test positive and if questionnaire negative patients were SARSCoV-2 test negative, then estimated sensitivity and specificity of an each questionnaire. Results and Conclusions: In a case of April 7 questionnaire, sensitivity was estimated as 88.2% and specificity was estimated as 59.5%. In a case of May 20 questionnaire, sensitivity was estimated as 75.0% and specificity was estimated as 54.9%. In a case of July 27 questionnaire, sensitivity was estimated as 67.3% and specificity was estimated as 53.3%. Many Covid-19 questionnaires are opened on the internet. All questionnaires contain item of fever, but our survey shows if a patient has fever is not useful to diagnose if he is Covid-19 positive or negative. But items of impaired sense of taste and smell, fatigue, and hardness of breath are useful. On basis of our survey, we are going to propose a more effective questionnaire.

Takeshi Oshio 1 , Norio Kodaka 1 , Chihiro Nakano 1 , Kayo Watanabe 1 , Kumiko Niitsuma 1 , Hirotsugu Morita 1 , Takatomo Hirouchi 1 , Yuka Yamada 1 , Hiroto Matsuse 1 1 Respiratory Medicine, Toho University Ohashi Medical Center, Japan

Rationale: It has been reported that various symptoms persist for a long period of time when suffering from COVID19, and new symptoms appear later. However, the clinical characteristics of these persistent and delayed symptoms has not yet been clarified. Methods: For COVID19 patients who were admitted to our hospital from April 2020, the physical symptoms that occurred from the day of onset to the day of discharge were recorded. We conducted a telephone interview survey on the presence or absence of persistent symptoms and delayed symptoms 30 and 60 days after discharge. In addition, we divided the group into those who developed pneumonia and those who did not, and examined the relationship with the symptoms of COVID-19. Results: The mean age was 59 years, 17 males and 22 females, with an average hospital stay of 15 days. The initial symptoms were fatigue, sore throat, cough, dyspnea, and arthralgia, and the symptoms that persisted during the recovery period were fatigue, loss of appetite, anosmia, and ageusia. Hair loss was observed in the delayed symptoms, but only in a few patients. There was no statistically significant difference in the association between initial and persistent and delayed symptoms and pneumonia, but there was a tendency for more symptoms in the group without pneumonia.

Conclusions: The present study shows that most patients requiring hospitalization for COVID-19 still have persistent symptoms after being discharged and it's potentially reduce patients' QOL and require treatments.

Polymerase chain reaction (PCR) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is useful, however, if it is negative result especially in the early phase of illness, PCR should be repeated to confirm the result. Simultaneous detection of other respiratory viruses might be helpful to avoid both unnecessary additional PCR test for SARS-CoV-2 and excess isolation of patient. Based on this perspective, it is important to understand the epidemics of respiratory viruses during COVID-19 pandemic. Methods: We examined stored respiratory specimens collected from suspected COVID-19 patients between

To test SARS-CoV-2, conventional PCR (National Institute for Infectious Diseases [NIID] in Japan) and AllplexTM SARS-CoV-2 Assay (Seegene) were used and compared the results. Results: Respiratory viruses but SARS-CoV-2 were detected in 114 out of 535 respiratory samples (21.3%), and human rhinovirus was most common. Co-infection of SARS-CoV-2 and other respiratory viruses were seen in 10 samples. Positive and negative agreement rate between NIID method and AllplexTM SARS-CoV-2 Assay were 95.5% and 93.1%, respectively. Discussion: Our result revealed that other respiratory viruses were commonly detected even during COVID-19 pandemic