key: cord-0959078-hc4pql01
authors: Cavalcante, Marcelo Borges; Sarno, Manoel; da Silva, Arlley Cleverson Belo; Barini, Ricardo
title: Letter: COVID-19 and human reproduction: hypothesis need to be investigated
date: 2020-06-05
journal: Mol Hum Reprod
DOI: 10.1093/molehr/gaaa041
sha: a2f08f2b52d2399bffe0a3b95faa22188d7533c0
doc_id: 959078
cord_uid: hc4pql01

nan

organs. The SARS-CoV epidemic occurred in 2002/2003 to a lesser extent than COVID-19. At that time, Xu et al. (2006) warned of a possible negative impact on the fertility of survivors of SARS-CoV. They described six orchitis cases in autopsies of men who died due to SARS-CoV (Xu et al., 2006) . Animal studies have also demonstrated an association of avian infectious bronchitis virus (AIBV), a coronavirus known to cause an acute respiratory infection in chickens, with a reduction in fertility of roosters and chickens (Boltz et al., 2004; Villarreal et al., 2007) .

Recently, the hypothesis of Fan et al. (2020) started to be investigated. Li et al. (2020) demonstrated the presence of SARS-CoV-2 in 06 semen samples from a total of 38 men (06/ Unfortunately, the paper by Jing et al. (2020) may seem sensationalistic and opportunistic to some critics. However, as we stated earlier, science is made from hypotheses that need to be confirmed or refuted. In the case of the Fan et al. (2020) hypothesis, it is already possible to

Avian infectious bronchitis virus: a possible cause of reduced fertility in the rooster

Structure analysis of the receptor binding of 2019-nCoV

ACE2 Expression in Kidney and Testis May Cause Kidney and Testis Damage After 2019-nCov Infection

Potential influence of COVID-19/ACE2 on the female reproductive system

Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease

Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and nonobstructive azoospermia (NOA) human male testes

Effect of SARS-CoV-2 infection upon male gonadal function: A single center-based study

Orchitis in roosters with reduced fertility associated with avian infectious bronchitis virus and avian metapneumovirus infections