key: cord-0956988-64ahnjpt authors: Fiest, Kirsten M.; Krewulak, Karla D.; Plotnikoff, Kara M.; Kemp, Laryssa G.; Parhar, Ken Kuljit S.; Niven, Daniel J.; Kortbeek, John B.; Stelfox, Henry T.; Parsons Leigh, Jeanna title: Allocation of intensive care resources during an infectious disease outbreak: a rapid review to inform practice date: 2020-12-18 journal: BMC Med DOI: 10.1186/s12916-020-01871-9 sha: 332aaeaeda90fa5699d59fe03821a48e6817abbf doc_id: 956988 cord_uid: 64ahnjpt BACKGROUND: The COVID-19 pandemic has placed sustained demand on health systems globally, and the capacity to provide critical care has been overwhelmed in some jurisdictions. It is unknown which triage criteria for allocation of resources perform best to inform health system decision-making. We sought to summarize and describe existing triage tools and ethical frameworks to aid healthcare decision-making during infectious disease outbreaks. METHODS: We conducted a rapid review of triage criteria and ethical frameworks for the allocation of critical care resources during epidemics and pandemics. We searched Medline, EMBASE, and SCOPUS from inception to November 3, 2020. Full-text screening and data abstraction were conducted independently and in duplicate by three reviewers. Articles were included if they were primary research, an adult critical care setting, and the framework described was related to an infectious disease outbreak. We summarized each triage tool and ethical guidelines or framework including their elements and operating characteristics using descriptive statistics. We assessed the quality of each article with applicable checklists tailored to each study design. RESULTS: From 11,539 unique citations, 697 full-text articles were reviewed and 83 articles were included. Fifty-nine described critical care triage protocols and 25 described ethical frameworks. Of these, four articles described both a protocol and ethical framework. Sixty articles described 52 unique triage criteria (29 algorithm-based, 23 point-based). Few algorithmic- or point-based triage protocols were good predictors of mortality with AUCs ranging from 0.51 (PMEWS) to 0.85 (admitting SOFA > 11). Most published triage protocols included the substantive values of duty to provide care, equity, stewardship and trust, and the procedural value of reason. CONCLUSIONS: This review summarizes available triage protocols and ethical guidelines to provide decision-makers with data to help select and tailor triage tools. Given the uncertainty about how the COVID-19 pandemic will progress and any future pandemics, jurisdictions should prepare by selecting and adapting a triage tool that works best for their circumstances. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-020-01871-9. Five pandemics occurred in the last century: H1N1 (1918), H2N2 (1957) (1958) , H3N2 influenza (1968), the H1N1 virus (2009) [1] [2] [3] , and the novel coronavirus SARS-CoV-2 (COVID-19) (2020) [4] . Viral infections caused by influenza or coronavirus may lead to organ failure, including respiratory illness, which can progress to hypoxemic respiratory failure and the acute respiratory distress syndrome, requiring admission to an intensive care unit (ICU) [5] . ICUs are specialized units wherein highly trained specialists work with a multidisciplinary team to deliver life sustaining therapies [6] . The availability of ICU beds varies across countries ranging from 0 (low-income countries such as South Sudan) to 59.5 (high-income countries such as Monaco) adult ICU beds per 100,000 population [7] . With the world's population over 7.8 billion [8] , rapid viral spread during a pandemic can overwhelm ICU resources [9, 10] (e.g., staff, beds, ventilators, extracorporeal life support). It is essential that hospitals have a strategy to ensure equitable and ethical resource allocation if the demand for ICU resources exceeds supply [11] . One such strategy is a triage protocol, which is a set of criteria that are enacted during resource scarcity to determine which patients should be admitted to an ICU or continue to receive care in an ICU. Recent reviews discuss the principle of triage and implementation of triage plans [12] , quality of criteria to triage and transfer critically ill patients [13] , and ethical principles used in disaster response [14, 15] . However, it is unclear which triage criteria perform best. In light of the ongoing COVID-19 pandemic, we conducted a rapid review of the published triage literature to evaluate the validity of published triage protocols and the mortality prediction embedded within them to help inform health system-decisionmaking. We conducted a rapid review to ensure timeliness of data in response to the COVID-19 pandemic and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards where possible (as no guideline for rapid reviews exists) [16] (Supplementary Appendix 2, Additional File 1). The search strategy included the following: (1) terms for critical care (e.g., ICU, intensive care, mechanical ventilation); (2) terms for pandemics, epidemics, and infectious disease outbreaks (e.g., avian influenza, Severe Acute Respiratory Syndrome [SARS] , Middle East Respiratory Syndrome [MERS] , ; and (3) terms for triage criteria, resource allocation, and ethical frameworks (e.g., triage, resource allocation) (see Supplementary Appendix 2, Additional File 1). The search was executed on November 3, 2020, in three databases: MEDLINE (Ovid), EMBASE (Ovid), and SCOPUS (Elsevier). References were exported and managed using EndNote X9 (Clarivate Analytics). To ensure inter-rater agreement, a random sample of 10% of included articles were pilot tested independently by three reviewers (KK, KP, LK) with 92% agreement. The remaining titles and abstracts were screened independently by one of three reviewers (KK, KP, LK). Studies were included if they were published in the English language and were (1) primary research and other research, including consensus-based study designs; (2) targeted critically ill adults (i.e., patients with lifethreatening respiratory, cardiovascular, or neurological illness or other illnesses necessitating life sustaining therapies only provided in an ICU and are ≥ 18 years old [or an adult as defined by the study]); and (3) described development or evaluation of triage criteria used on all patients (e.g., COVID and non-COVID) to allocate critical care resources during an infectious disease outbreak. Citations deemed eligible by any reviewer at the title and abstract stage were included for full-text review. Fulltext articles were similarly screened independently and in duplicate by three reviewers (KK, KP, LK). Disagreements were resolved by discussion or consensus with a fourth reviewer (KF). Reference lists were examined for any additional relevant studies not identified in the original search. The following data were recorded on a standardized form in Excel: study information (e.g., country of study conduct, year published, study design), participant characteristics (e.g., study population, sample size), and outcomes (e.g., triage guideline creation, evaluation of triage criteria, and triage protocols). Data are reported using descriptive statistics. The quality of included quantitative studies was assessed using the Joanna Briggs Institute Critical Appraisal tools for case control, cohort, cross-sectional, diagnostic test accuracy, quasi-experimental, qualitative, or text and opinion studies [17] [18] [19] [20] [21] [22] . The quality of Delphi techniques was assessed based on proposed recommendations by Jünger and colleagues. The quality of guidelines was assessed using the 23-item AGREE Reporting Checklist. In all cases, a higher number indicated better methodological quality. The literature search identified 11,539 unique citations (Fig. 1) . After assessing titles and abstracts for eligibility, 697 articles were included for full-text review. Eightythree articles were included in the final rapid review. The most common reasons for exclusion included not original research (249/614, 40.6%) or not reporting on the development or evaluation of triage criteria used on all patients in the context of an infectious disease outbreak (209/614, 34.0% (Fig. 1 Several studies were categorized as text and opinion (48/ 83, 57.8%), which was further defined as studies that include research evidence such as working groups, expert opinions, consensus, or current discourse for the purposes of this review. Among the 83 included articles, 52 unique critical care triage protocols from 59 articles and 25 ethical frameworks or recommendations from 25 articles were described. Four articles included both a triage protocol and an ethical framework [23] [24] [25] . Two articles were computer simulation models and were not assessed as a triage protocol or ethical framework [26, 27] Table 2 , Additional File 1). In the algorithmic approach, each patient is assessed for each criterion, which determines if the patient is eligible to receive critical care. For example, the Ontario Health Plan for an Influenza Pandemic (OHPIP) has four main components: inclusion criteria (patients who require critical resources), exclusion criteria (patients who have poor prognosis), minimum qualifications for survival (amount of resources required), and a prioritization tool (color scheme to prioritize patients for ICU admission and mechanical ventilation) [28] (Supplementary Table 2 , Additional File 1). Some algorithmic triage protocols are conceptually similar (7/29, 24.1%) (Supplementary Table 2 , Additional File 1). Few articles (10/29, 34 .5%) [29] [30] [31] [32] [33] [34] [35] [36] [37] describe supplemental criteria for situations where triage decisions cannot be reached after evaluating patients based on the criteria. These criteria included fair innings (5/10, 50%), random selection (3/ 10, 30%), multiplier effect/essential worker/caregiver/ healthcare provider/first come, and first served/groups subjected to social deprivation and disadvantage (each 2/ 10, 20%) (Supplementary Table 1 triage decisions cannot be reached after evaluating patients based on the OHPIP triage protocol (e.g., clinical evidence of a significantly better outcome, multiplier effect which is those with skills and knowledge to save others during the pandemic) [36] . The article by Winsor et al. summarizes common "supplementary criteria" and included a list of key considerations when jurisdictions are considering supplementary triage criteria. Most included algorithm triage protocols (18/29, 62.1%) included a Sequential Organ Failure Assessment (SOFA) score as exclusion criterion. Of these, 10 (10/18, 55.6%) proposed a SOFA score of > 11 to exclude patients from critical care resources [25, 28, 30, 34, 35, [38] [39] [40] [41] [42] . Seven did not state a cutoff [29, 31, [43] [44] [45] [46] [47] , and one proposed a SOFA score ≥ 14 or ≤ 8 [48] . Only four (4/29, 13.8%) triage protocols included a criterion for patient age (> 85 years) as an exclusion criterion [28, 34, 49, 50] . Seven (7/29, 24 .1%) include frailty as a criterion [29, 42, 44, 46, [51] [52] [53] . Most triage protocols (19/29, 65 .5%) include a reassessment and re-categorization of each patient (e.g., at 48 and 120 h) to determine if patients are improving and are still eligible for critical care [28-33, 35, 38, 39, 42-44, 46-49, 53, 54] . Twenty-three unique point-based triage protocols were described in the included studies (Supplementary and Severity Score for the Elderly with Community-Acquired Pneumonia) [60, [67] [68] [69] or intensive respiratory or vasopressor support (SMART-COP) in patients with community acquired pneumonia. Five (5/23, 21.7%) are commonly used scoring systems for severity of illness in the ICU or to determine if a patient requires critical care intervention and include the Acute Physiology And Chronic Health Evaluation-II/III (APACHE-II/ APACHE-III) [70, 71] , Modified Early Warning System (MEWS) [66] , SOFA [61, [70] [71] [72] [73] [74] [75] [76] , quick SOFA (qSOFA) [66] , or Simplified Acute Physiology Score (SAPS-II) [71] . Two included a scoring system for severe hypoxemic respiratory failure from acute respiratory distress (Murray score, PaO 2 /FiO 2 ratio) [63, 77] . One included a predictor of mortality for sepsis (Mortality in Emergency Department Sepsis [MEDS]) [60, 63] . Most pointbased triage protocols included the patient's age (12/23, 52.2%) ( Table 1 ) that is gender specific (PSI-men: points in years, women: points in years-10), includes age categories (e.g., 0-49, 50-69, 70-84, ≥ 85), a multiplier (e.g., 0.5x), or an age cutoff (e.g., ≥ 65, ≥ 75, ≥ 85). In all cases, the older the patient is, the more points they are assigned (i.e., less favorable). Nearly all point-based triage protocols (20/23, 87%%) included vital signs, with the most commonly included being respiratory rate (18/ 23, 78.3%), blood pressure (14/23, 60.9%), and heart rate (12/23, 52.2%). Nearly all point-based triage protocols included laboratory or radiographic findings, with oxygenation (14/23, 60.9%%) the most commonly included criterion. One point-based triage protocol deducted points (i.e., were more favorable) for patients who were pregnant [58] . Sixteen of the included studies described the accuracy of 18 critical care triage protocols (Supplementary Table 3 Table 3 , Additional File 1) [61-63, 72, 74] . Four of these studies evaluated the performance of an algorithm-based triage protocol [76, 78, 79] , with three evaluating the OHPIP [76, 78, 79] . Of the patients who met the criteria for OHPIP blue (i.e., palliative care only and would not be admitted to the ICU), 24.6-63.0% died and 27.3-75.4% survived [63, 76, 78, 79] . Of the patients who met the criteria for OHPIP red (i.e., high priority for ICU admission), 65-93.7% survived and 6.3-35.0% died ( Table 2) . One article used a machine-learning based algorithm, which predicted mortality in all ICU patients (AUROC 0.862) more accurately compared to the qSOFA (0.760), MEWS (0.833), and CURB-65 (0.652) [66] . The remaining articles evaluated the performance of pointbased triage protocols. Five articles evaluated four triage protocols developed for an infectious disease outbreak: CAT, P-MEWS, STSS, and SWiFT. No score was a good predictor of mortality with AUCs ranging from 0.58 (95% CI 0.46-0.69; P-MEWS) to 0.71 (95% CI 0.66-0.77; STSS) (Supplementary Table 3 , Additional File 1). Six included articles evaluated scoring systems for severity of illness in the ICU: APACHE-II/APACHE-III, MEWS, qSOFA/SOFA, and SAPS-II (Supplementary Table 3 , Additional File 1). The SOFA score on admission was a good predictor of 30-day mortality in one study with an AUC of 0.83 (95% CI 0.81-0.85]) [72] . Two studies reported that a SOFA score > 11 was a fair predictor of mortality (AUC 0.74 and 0.65) [70, 78] . Six studies reported in-hospital mortality in patients with a SOFA score > 11, which ranged from 0% [73] to 59% (95% CI 56-62%) [75] (Table 2) . Four included articles evaluated performance of predictors of mortality in community acquired pneumonia for triage of patients during a pandemic [57, 60, 67, 69] . No score was a good predictor of mortality with AUCs ranging from 0.64 (95% CI 0.58-0.71; PIRO-CAP) to 0.78 (95% CI 0.72-0.83; PSI). Thirty of the included articles explicitly stated which ethical principles guided the development of the triage criteria. Of these, twelve articles described ethical frameworks (12/30, 40%) and 13 described guiding principles or recommendations (13/30, 43.3%) for triage decisions during a pandemic (Supplementary Table 4 , Additional File 1). Four articles used an ethical framework or recommendation to inform the development of a triage protocol [23] [24] [25] 32] . Although terminology differed across the studies, they can be divided between substantive values (e.g., duty to provide care, equity, stewardship, etc.) and procedural values (e.g., reasonable, open and transparent, etc.) [80] (Table 3) . For example, most included the principle of stewardship (20/30, 66.7%) in [88, 93, 95, 98] engaged the public to prioritize triage criteria. In all studies, the criterion "most likely to survive" was perceived as fair or was prioritized. The criterion "first come, first served" was perceived as unfair or prioritized in the bottom half of the triage criteria [32, 58, 87, 88, 98] . Only five studies (5/30, 16.7%) supported allocation of resources based on societal contributions or reciprocity [10, 88, 90, 93, 98] . Several included papers described when triage criteria should be initiated, who should administer the triage criteria, an appeals process, if load leveling is possible to distribute patients throughout a region and consider vulnerable populations. Most included articles suggested that triage criteria be initiated when critical care resources have been overwhelmed despite all efforts to expand critical care capacity to meet demands [10, 11, 25, 29, 31, 32, 36, 40, 44, 46, 47, 50, 53, 58, 82-85, 89, 90, 92, 98, 101] . Some articles suggested that triage criteria be administered by a triage officer who is an intensivist or other physician with appropriate critical care experience and has no direct contact with the patient [10, 11, 33, 35, 37, 38, 79, 81, 85, 89] . Several articles suggested a triage team or committee to remove the burden of the decision from a single individual [23, 25, 29-32, 34-36, 47, 51, 52, 65, 83, 93, 102] . This triage team may be important when decisions using supplementary criteria are involved [34, 103] or if there are appeals from family or clinicians [23, 24, 92, 93] . This triage team is recommended to include a senior ICU physician, non-physician ICU healthcare professional, and a professional from outside the ICU. This triage process may be overseen by a triage review board [99] or include prospective (i.e., during an appeals process) or retrospective review to ensure accountability, consistent application of the triage criteria, and an adequate level of prioritization (i.e., not over or under triaging) [11, 33, 34, 42, 89] . Several articles suggested that an appeals process is not feasible given time and resource constraints [24, 36, 89] . Some articles recommend including an appeal process, but limiting appeals to deviations from the triage process or reevaluations due to updated clinical information [10, 11] . Articles discussed a regionalization scheme for highly sophisticated critical care (e.g., ECMO) [77] or transferring patients to less strained ICUs [38, 42] . When withdrawing critical care from one patient to reallocate it to another patient with a better prognosis [98] , articles outline the ethical [24] and legal challenges associated [90] . Some articles described the importance of educating the public on triage criteria and early family involvement in decision-making as a way to potentially mitigate some of the issues raised by families when decisions to withhold care are made [23, 24, 92, 93] . Several articles advocated for the consideration of vulnerable populations [96] to ensure that medical treatment in the context of a pandemic is not restricted to those able to pay [10] or that allocation decisions do not replicating existing inequities (e.g., insured vs. uninsured, urban vs. rural) [98] . Moreover, secondary triage factors may be necessary for selecting among patients with similar prognosis. In this case, the fairest option in the included articles was randomization versus first-come first-served, which penalized people of lower socio-economic means or minority populations [10, 35] . Several articles recommend the use of advanced age as triage criterion [45] , while others reject the use of age and instead encourage frailty, which takes into consideration functional and cognitive status and burden of comorbidities [35, 42, 44, 50, 81] . Of 83 included articles, 80 were evaluated for quality (Table 4 ). Three articles could not be assessed because we could not find quality criteria for evaluating studies that included a computer-generated study population or development of an intelligence dashboard [26, 27, 65] . Five included studies were published conference abstracts and, as such, we did not have enough methodological information to determine their risk of bias. The remaining 75 full-text articles were deemed of sufficient quality to include in analyses (Table 4 ). The current study summarizes the literature from 83 studies that described triage criteria created before, during, and after infectious disease outbreaks (e.g., H1N1, SARS, H5N1, MERS, Ebola, . Of the 52 triage criteria from 60 articles, 29 were algorithmic-based and 23 were point-based. There were 30 articles that describe ethical frameworks or guiding principles for triage decisions. Most of the algorithm-based triage criteria are based on the OHPIP triage protocol for critical care [28] or included a SOFA score when making triage decisions. Most point-based triage protocols consider the patient's age or vital signs in the total score. Most triage criteria have not been validated and the operating characteristics for those that have (e.g., SOFA) to predict mortality are modest. It is expected that triage protocols should perform better than first-come, first served distribution of resources as a means to allocate scarce resources and maximize patient survival [27] . However, the results of this rapid review suggest that most protocols are not validated or do not have sufficient criterion validity to predict mortality. Validated scoring systems such as a SOFA or APACHE-II score or pneumonia scoring systems were designed for a specific population and have been demonstrated to be less accurate when used in other patient populations [97, [104] [105] [106] [107] [108] . A recent systematic review on prediction models for diagnosis and prognosis of COVID-19 reported that proposed models were poorly described, had a high risk of bias, and may be unreliable Table 3 Substantive and procedural values in published ethical frameworks and guiding principles for critical care triage during a pandemic (n = 30) (Continued) Example n (%) Author (year published) (2020) [84] ; Valiani (2020) [29] Inclusive "Hospitals should establish procedure in advance of a crisis. These protocols should be developed regionally and with input from stakeholders (including the public when used in situ [109] . Most triage protocols were developed with experts (e.g., ethicists, lawyers, healthcare professionals, decision-makers and, in some cases, members of the public) in advance of a pandemic (e.g., CHES T consensus statements) [11, 88, 91, 96, 100, 110] or were validated using a non-representative population (e.g., patients with COVID-19, seasonal influenza or ARDS) [111] [112] [113] [114] [115] [116] [117] [118] [119] . As such, most triage criteria are not validated (and it may not be possible to validate them) prior to their use. Our study adds to the existing reviews that discuss implementation of triage plans [12] , ethics of triage [14] , ventilator triage policies [15] , and quality of criteria to triage and transfer critically ill patients [13] by providing decision-makers with data to help them select and tailor tools best for their jurisdictions. In general, triage is grounded by utilitarian theory or "the greatest good for the greatest number" or egalitarianism or "equal distribution of resources." Both considerations are warranted during an infectious disease outbreak as triage criteria should benefit society (utilitarian) but ensure fairness (egalitarian). As such, health systems should weigh ethical principles and decide which core values should underpin the triage criteria. In addition to identifying patients at a high risk of mortality (e.g., 80-90%), triage protocols should also separate patients into cohorts of relative prognosis (e.g., 40-50-60%) with frequent revaluation in order to apply a utilitarian framework, as opposed to queuing or randomization. This rapid review suggests that most triage criteria were developed by a panel of experts and few sought public input. Triage criteria should be anchored by the procedural value of open and transparent and the substantive value of trust by engaging the public in triage development and educating the public on triage during a pandemic. In some cases, triage criteria may include the substantive value of reciprocity. For example, the developers of the Newfoundland and Labrador Critical Care Triage protocol [34] considered Indigenous populations where the death of an elder may have a devastating impact on this community. Low-income countries (e.g., South Sudan) have a shortage of skilled critical care healthcare professionals and, as such, these healthcare professionals should be given priority for receiving scarce resources because they could assist in the care of critically ill patients after they recover [120] . Health systems need to pick triage tools that consider cultural values and ideologies while adhering to utilitarian and egalitarian principles. The large number of patients admitted to ICU during the COVID-19 pandemic provides an opportunity to validate (retrospectively and prospectively), improve, and standardize selected triage tools. This may include evaluating how well they work as prognostic models to predict mortality and length of ICU stay or length of mechanical ventilation (i.e., utilization of resources) or the ability for each criterion or a combination of criteria identified by this rapid review (e.g., age, sex, comorbidities, vital signs, SOFA score) to act as proxies for outcomes. This is important given the uncertainty about how the current pandemic will evolve and when future pandemics will occur. This should include engaging the public to ensure that triage criteria represent societal values as well as to inform members of the public how decisions will be made [87, 92, 93, 98, 100] . There are several strengths of our rapid review. The timely synthesis of published triage criteria is important for health systems to respond to the current pandemic and prepare for future pandemics and for evidence to be generated on the utility of the currently available triage criteria to allocate scarce resources and maximize survival. The rapid review followed rigorous methodology [121] that included a search strategy created with experts, a comprehensive literature review, and all steps (full-text screening, data extraction and quality assessments) completed independently and in duplicate. There are several limitations of our rapid review that should be considered. This includes the possibility that some studies were missed in the search, during selection of studies, or because of the rapidly evolving COVID-19 literature. This also includes the exclusion of unpublished triage criteria that is available on institutional, government or society websites though most of these triage criteria either are adapted from or cite triage criteria included in this review. The current study provides a catalog of possible criteria, but with only limited data on which criteria work best. Included studies were largely developed outside of the scope of pandemics or infectious disease outbreaks, as it is difficult to know how they will perform during an infectious disease outbreak. Additionally, our review is focused on an adult critical care setting as pediatric populations use different types of triage criteria. Resource allocation and triage in pediatric groups has been explored elsewhere [122, 123] . Regardless of the operating characteristics, healthcare systems need to decide which triage protocol to enact if the demand of critical care resources exceeds supply to ensure a standardized and ethically sound approach to allocating health resources. This rapid review summarizes the existing published triage criteria used for epidemics or pandemics when ICU resources are scarce. Despite the limited validation of criteria and the modest operating characteristics of those criteria that have been validated, our study provides healthcare decision-makers with a list of available criteria, their elements, and their operating characteristics. Given the uncertainty of how the current pandemic will evolve and when future pandemics occur, all healthcare systems need to pick the criteria that work best for their circumstances. The triage process needs to adhere to utilitarian and egalitarian principles. 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A scoping review of rapid review methods Prediction of pediatric critical care resource utilization for disaster triage Triage of mechanical ventilation for pediatric patients during a pandemic A Simple Three-Tier Classification System for Triage, Communication, and Resource Utilization by Patients Afflicted with COVID-19 Disease The role of pneumonia scores in the emergency room in patients infected by 2009 H1N1 infection Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations The authors would like to thank Nicole Dunnewold (University of Calgary) with their help reviewing the search strategies. All authors contributed to the study conception and design. KDK, KMP, and LGK performed the literature search and data collection. All authors contributed to data analysis. The first draft of the manuscript was written by KMF, KDK, and KMP, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript. JPL had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Opportunity -Operating Grant (grant number RN420046-439965) to JPL. The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. KKSP is a member of the advisory board for Elsius Biomedical but has received no direct or indirect compensation and has received research grant funding from the CIHR and the MSI Foundation. All other authors declare no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years, and no other relationships or activities that could appear to have influenced the submitted work. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study. Competing interests KKSP is a member of the advisory board for Elsius Biomedical but has received no direct or indirect compensation and has received research grant funding from the CIHR and the MSI Foundation. All other authors declare no support from any organization for the submitted work, no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years, and no other relationships or activities that could appear to have influenced the submitted work.