key: cord-0954373-7rhd9avi
authors: Temiz, Selami Aykut; Abdelmaksoud, Ayman; Dursun, Recep; Vestita, Michelangelo
title: Acral chilblain‐like lesions following inactivated SARS‐CoV‐2 vaccination
date: 2021-04-26
journal: Int J Dermatol
DOI: 10.1111/ijd.15619
sha: 1571ed9c703046f79589ac18f8e491e03c2850db
doc_id: 954373
cord_uid: 7rhd9avi

nan

ally adenoviruses) vaccines that trigger the immune response by revealing the SARS-CoV-2 genes. 1 Cutaneous lesions related to COVID-19 may be attributed to a collateral effect of the activation of the immune system rather than being a direct effect of the virus, despite relatively common. 2 Cutaneous reactions following COVID-19 vaccination, such as herpes zoster and lichen planus, have been reported. 3 Herein, we present two cases who developed acral chilblain-like lesions (CLL) after the 5 reported a case of "blue toes" in a 40-year-old woman 4 days after the first dose with "Pfizer-BioNTech-162b2 vaccine". It has been attributed to the fact that the inactivated vaccine can affect the immune system in a similar way to COVID-19 disease. 1 Further accumulating case reports/series are awaited to further confirm or refute our observation. Till that, it should be considered that CLL may develop in patients recently administered inactivated SARS-CoV-2 vaccine.

Selami Aykut Temiz 1 , MD Ayman Abdelmaksoud 2 *, MSc

Development of an inactivated vaccine candidate for SARS-CoV-2

Absence of SARS-CoV-2 RNA detection in tissue samples of COVID-19-related cutaneous lesions analyzed by real-time RT-PCR

COVID-19 "second wave" and vaccines: the dermatologists' perspective

Relapse of chilblainlike lesions during the second wave of coronavirus disease 19

Blue toes' following vaccination with the BNT162b2 mRNA COVID-19 vaccine

Funding source: None. doi: 10.1111/ijd.15619