key: cord-0953923-mrwpxvet
authors: Mortier, P.; Vilagut, G.; Ferrer, M.; Alayo, I.; Bruffaerts, R.; Cristóbal-Narváez, P.; del Cura-González, I.; Domènech-Abella, J.; Felez-Nobrega, M.; Olaya, B.; Pijoan, J. I.; Vieta, E.; Pérez-Solà, V.; Kessler, R. C.; Haro, J. M.; Alonso, J.
title: Thirty-day suicidal thoughts and behaviours in the Spanish adult general population during the first wave of the Spain COVID-19 pandemic
date: 2021-02-17
journal: Epidemiol Psychiatr Sci
DOI: 10.1017/s2045796021000093
sha: 673385bbe5542ec7efb684f6be05edd0f4d450a1
doc_id: 953923
cord_uid: mrwpxvet

AIMS: To investigate the prevalence of suicidal thoughts and behaviours (STB; i.e. suicidal ideation, plans or attempts) in the Spanish adult general population during the first wave of the Spain coronavirus disease 2019 (COVID-19) pandemic (March−July, 2020), and to investigate the individual- and population-level impact of relevant distal and proximal STB risk factor domains. METHODS: Cross-sectional study design using data from the baseline assessment of an observational cohort study (MIND/COVID project). A nationally representative sample of 3500 non-institutionalised Spanish adults (51.5% female; mean age = 49.6 [s.d. = 17.0]) was taken using dual-frame random digit dialing, stratified for age, sex and geographical area. Professional interviewers carried out computer-assisted telephone interviews (1–30 June 2020). Thirty-day STB was assessed using modified items from the Columbia Suicide Severity Rating Scale. Distal (i.e. pre-pandemic) risk factors included sociodemographic variables, number of physical health conditions and pre-pandemic lifetime mental disorders; proximal (i.e. pandemic) risk factors included current mental disorders and a range of adverse events-experiences related to the pandemic. Logistic regression was used to investigate individual-level associations (odds ratios [OR]) and population-level associations (population attributable risk proportions [PARP]) between risk factors and 30-day STB. All data were weighted using post-stratification survey weights. RESULTS: Estimated prevalence of 30-day STB was 4.5% (1.8% active suicidal ideation; n = 5 [0.1%] suicide attempts). STB was 9.7% among the 34.3% of respondents with pre-pandemic lifetime mental disorders, and 1.8% among the 65.7% without any pre-pandemic lifetime mental disorder. Factors significantly associated with STB were pre-pandemic lifetime mental disorders (total PARP = 49.1%) and current mental disorders (total PARP = 58.4%), i.e. major depressive disorder (OR = 6.0; PARP = 39.2%), generalised anxiety disorder (OR = 5.6; PARP = 36.3%), post-traumatic stress disorder (OR = 4.6; PARP = 26.6%), panic attacks (OR = 6.7; PARP = 36.6%) and alcohol/substance use disorder (OR = 3.3; PARP = 5.9%). Pandemic-related adverse events-experiences associated with STB were lack of social support, interpersonal stress, stress about personal health and about the health of loved ones (PARPs 32.7–42.6%%), and having loved ones infected with COVID-19 (OR = 1.7; PARP = 18.8%). Up to 74.1% of STB is potentially attributable to the joint effects of mental disorders and adverse events−experiences related to the pandemic. CONCLUSIONS: STB at the end of the first wave of the Spain COVID-19 pandemic was high, and large proportions of STB are potentially attributable to mental disorders and adverse events−experiences related to the pandemic, including health-related stress, lack of social support and interpersonal stress. There is an urgent need to allocate resources to increase access to adequate mental healthcare, even in times of healthcare system overload. STUDY REGISTRATION NUMBER: NCT04556565

The coronavirus disease 2019 (COVID-19) pandemic poses unprecedented challenges worldwide. In line with concerns about a potential increase in psychopathology related to the pandemic (Vindegaard and Benros, 2020) , representative populationbased studies (i.e. not using snowball sampling) from the Czech Republic, the UK and the US found high prevalence of suicidal thoughts and behaviours (STB) during the pandemic, i.e. suicidal ideation range 4.6-18% and suicidal behaviour range 0.1-4.9% (Bryan et al., 2020; Czeisler et al., 2020; Fitzpatrick et al., 2020; Gratz et al., 2020; Iob et al., 2020; O'Connor et al., 2020; Winkler et al., 2020; Ammerman et al., 2021) . Mental health experts have therefore urged governments to invest resources in mental health and suicide prevention strategies (Gunnell et al., 2020; Moutier, 2020; Wasserman et al., 2020) . To guide intervention planning, research is needed to provide reliable STB prevalence estimates and to quantify the population-level impact of relevant risk factors (Christensen et al., 2016) . The latter can be achieved by calculating population attributable risk proportions (PARP; Krysinska and Martin 2009) , i.e. estimates of potential reductions in STB when eliminating risk factors in the population. Despite their great value in prioritising prevention interventions (Christensen et al., 2016) , no study to date provided PARP for STB during the COVID-19 pandemic.

Spain was hit particularly hard by the COVID-19 pandemic. The first COVID-19 case in Spain was confirmed on 31 January 2020. On 14 March, a state of alarm was declared, including national lockdown restrictions requiring citizens to stay at home except to purchase food and medicines, or to go to work. Schools and all non-essential shops and businesses were closed. As from 28 April, all activity in non-essential sectors was banned. Between the beginning of March and mid-April, daily new cases were >2000/day, peaking on 27 March (10 141 cases; . During the last two weeks of March, daily hospitalisations were >2000/day (RENAVE, 2020) . Daily deaths peaked on 1 April (913 deaths) with 29 080 cumulative deaths by the end of May (WHO COVID-19 Dashboard). The healthcare system nearly collapsed during April−May due to lack of healthcare resources (RENAVE, 2020) . By the time the situation stabilised in early July, Spain had the eighth highest number of cases (i.e. 249 659), and the fifth highest COVID death rate (i.e. 60.7/100 000) in the world (Roser et al., 2020) .

In this report we investigate 30-day STB during the first wave of the COVID-19 pandemic (March−June 2020) in the Spanish adult general population. Spain traditionally has low rates of STB (12-month estimates 0.7-0.9%; Miret et al., 2014) and suicide (3.5-9.0/100 000; Alfonso-Sánchez et al., 2020) , but this might have changed due to the particularly severe toll of in Spain in terms of number of cases and deaths, healthcare system overload and a prolonged period of national lockdown. No previous data exist on STB prevalence during the pandemic in Spain other than from an online survey (March 2020) based on non-representative snowball sampling (Sáiz et al., 2020) . Representative estimates could contribute to the ongoing debate as to whether STB have increased during the pandemic. Here, we present data from a nationally representative sample assessed near the end of the first wave of the Spain COVID-19 pandemic (June 2020). By that time, daily new cases were <500/day, and restrictions were lifted to obtain a 'new normality', including social distancing, obligatory wearing of masks and limited capacity in shops, bars and restaurants.

Apart from STB prevalence, we also investigate a range of relevant STB risk factors for individual-and population-level impact. Distal risk factors (i.e. referring to the pre-pandemic period) include sociodemographic variables (Franklin et al., 2017; Carrasco-Barrios et al., 2020) , physical health conditions (Franklin et al., 2017) and pre-pandemic mental disorders (Nock et al., 2015; Franklin et al., 2017; O'Connor et al., 2020) . Proximal risk factors (i.e. referring to the pandemic period) are current mental disorders (Fitzpatrick et al., 2020; Iob et al., 2020) ; health-related factors, including COVID-19 infection (Iob et al., 2020; Winkler et al., 2020) and health-related stress (Winkler et al., 2020; Ammerman et al., 2021) ; financial factors (Fazel and Runeson, 2020) , including COVID-19-related financial stress or job loss (Gratz et al., 2020; Winkler et al., 2020) ; and interpersonal factors, including interpersonal stress and lack of social support (O'Connor and Kirtley, 2018; Carrasco-Barrios et al., 2020) .

This study is explanatory in purpose, and risk factors are therefore conceptualised as causal factors, i.e. factors that, when manipulated (e.g. through interventions), may change the outcome (Schooling and Jones, 2018) . However, this is an exploratory observational study without experimental manipulation, using a cross-sectional study design. No temporality between the risk factors and the outcome can be established, and therefore, no causal inference can be made.

A baseline survey of a cohort of general population adults was conducted as part of the MIND/COVID project (MIND/COVID, 2020). The target population consisted of non-institutionalised Spanish adults (i.e. aged 18 years or older) without Spanish language barriers. Professional interviewers carried out computer-assisted telephone interviews (1-30 June 2020) in a sample drawn using dual-frame random digit dialing (n = 3500). Mobile numbers were generated through an automated system and landline numbers were selected from an internal database maintained by the survey company to ensure that all Spanish geographical areas were adequately represented. Up to seven calls at different times of the day and days of the week were attempted to each number. The distribution of the interviews was planned according to quotas in terms of age groups, sex and autonomous community (National Institute of Statistics in Spain, July 2019 . For analyses, three dichotomies were created: "any STB" (i.e. having any of the four STB outcomes), "passive suicidal ideation only" and "active suicidal ideation, plan or attempt", with no STB as the reference level'. Distal risk factor domains included in this study are sociodemographic variables, number of physical health conditions and type and number of pre-pandemic lifetime mental disorders. Proximal risk factor domains are type and number of current mental disorders as well as four risk factor domains considering adverse events-experiences related to the pandemic: personal health-related factors, factors related to the health of loved ones, financial factors and interpersonal factors.

Socio-demographic variables included age (i.e. 18-29/30-49/ 50-64/65 < years), sex, nationality (i.e. non-Spanish nationality or both Spanish and non-Spanish nationality, v. Spanish nationality only), marital status (i.e. single, divorced or legally separated, widowed and married), living with a partner, pre-pandemic level of income (i.e. <570/570-799/800-1049/1050-1299/1300-1549/ 1550-1799/1800-2199/2200-2699/2700-3599/3600-4499/4500-5999/6000 < euros), having children in care, having elderly people or people with a disability in care and work status (i.e. essential service worker, non-essential service worker, not working).

Physical health conditions were assessed using a 7-item checklist (Sangha et al., 2003) including respiratory diseases (not provoked by coronavirus), cardiovascular diseases, diabetes, cancer, chronic hepatic diseases, immunological diseases and 'other'. A sum score was created and categorised into 'none', 'exactly one', 'exactly two' and 'three or more'.

Pre-pandemic lifetime mental disorders were assessed using a checklist based on the Composite International Diagnostic Interview (CIDI; Kessler and Üstün 2004) that screens for depression, bipolar disorder, anxiety, panic attacks, alcohol and drug use problems and 'other' mental disorders. A sum score was created and categorised into 'none', 'exactly one' and 'two or more'.

Current mental disorders were assessed using well-validated screener scales, i.e. two-week major depressive disorder (PHQ-8; cutoff score 10; Kroenke et al., 2009) , two-week generalised anxiety disorder (GAD-7; cutoff score 10; Newman et al., 2002) , 30-day panic attacks (adapted CIDI screening scale item; Kessler et al., 2013) , 30-day post-traumatic stress disorder (4-item short form of the PCL-5; cutoff score 7; Zuromski et al., 2019) and 30-day alcohol and substance use disorders (CAGE-AID; cutoff score 2; Hinkin et al., 2001) . A sum score was created and categorised into 'none', 'exactly one' and 'two or more'.

Personal health-related factors included: a history of COVID-19 infection (positive test and/or medical diagnosis) and/or having been in isolation or quarantine related to COVID-19 (three items recoded into a dichotomy); number of close contacts (<1 m) when working outside of home (0-100); perceived inefficiency of available protective equipment at work (4-level Likert-type item ranging from 'sufficient' to 'completely insufficient'); and personal health-related stress, i.e. a summary scale [0-4] of two 5-level Likert-type items (ranging from 'none' to 'very severe') adapted from the Peri Life Events Scale (PLES; Dohrenwend et al., 1978) assessing stress related to personal health and to potential COVID-19 infection.

Factors related to the health of loved ones included: having loved ones infected with COVID-19 (including type of loved one infected and severity of infection of most affected loved one); and stress related to loved ones' health, i.e. a summary scale [0-4] of two 5-level Likert-type adapted PLES items (ranging from 'none' to 'very severe') assessing stress related to the health of loved ones and to loved ones potentially getting infected with COVID-19 (Dohrenwend et al., 1978) .

Financial factors included: a significant loss of income and/or [temporary] unemployment due to COVID-19 (two items recoded into a dichotomy); and financial stress, i.e. a summary scale [0-4] of two 5-level Likert-type adapted PLES items (ranging from 'none' to 'very severe') assessing financial stress and stress related to loss of job or income due to COVID-19 (Dohrenwend et al., 1978) .

Interpersonal factors included: interpersonal stress, i.e. a summary scale [0-4] of four 5-level Likert-type adapted PLES items (ranging from 'none' to 'very severe') assessing stress related to romantic relationships, family relationships, other problems of loved ones and getting along with people at work (Dohrenwend et al., 1978) ; and lack of social support using the reverse scaled [0-4] Oslo Social Support Scale (Dalgard, 1996) .

All analyses were conducted using SAS version 9.4 (SAS Institute Inc, 2013). Post-stratification weights were used to match the sample to the distribution of the Spain adult general population according to age groups, sex and geographic region. Item-level missing data were minimal (median 0.09% [IQR 0.03-0.25%]; see also online Supplementary Table 1 ) and addressed using single multivariable imputation by chained equations (van Buuren, 2018).

STB prevalence was estimated for the entire sample and stratified by distal risk factors and current mental disorders. Logistic regression was used to estimate individual-level associations (odds ratios [OR] with 95% CI) of the risk factors with the three STB outcomes. To deal with data sparseness, penalised maximum likelihood estimation (Firth-type estimation) was used (Allison, 2012) . Population-level associations, i.e. population attributable risk proportions (PARP % [S.E.]; Krysinska and Martin 2009) were calculated using simulation methods based on the logistic regression equations. PARP is the proportion of the cumulative predicted value of an outcome explained statistically by specific predictor variables. If the odds ratios from the logistic regression equations represent causal effects of the risk factors under study, PARP can be interpreted as the expected proportional reduction in STB prevalence if STB risk factors were eradicated from the population.

Since causal relationships between the included risk factors are largely unknown, we refrained from constructing fully adjusted multivariable models to avoid the risk of overadjustment bias (Schisterman et al., 2009) . A first series of analyses considered the distal risk factor domains. We estimated bivariable individuallevel associations of socio-demographic variables and number of physical health conditions with each of the STB outcomes. Next, we estimated individual-and population-level associations of pre-pandemic lifetime mental disorders with STB using separate models for each type of disorder and for number of disorders, each time adjusting for sociodemographic variables and number of physical health conditions (i.e. the remaining distal risk Epidemiology and Psychiatric Sciences factors). Unadjusted (bivariable) models are shown in the Supplement. We also calculated a total PARP representing the joint effects of type and number of pre-pandemic lifetime mental disorders using a model including seven dummy variables indicating the seven types of disorders plus one dummy variable indicating having two or more disorders (see Nock et al., 2015 for a detailed discussion of type-number models), again adjusting for the remaining distal risk factors.

A second series of analyses considered the proximal risk factors. We estimated individual-and population-level associations of proximal risk factors with STB using separate models for each proximal risk factor, each time adjusting for distal risk factors. Unadjusted (bivariable) models are shown in the Supplement. Next, we calculated total PARPs representing the joint effects of the risk factors belonging to each separate proximal risk factor domain, each time adjusting for all distal risk factors. Similar to the total PARP for pre-pandemic lifetime mental disorders, the total PARP for current mental disorders consisted of a typenumber model including five dummy variables indicating the five types of disorders plus one dummy variable indicating having two or more disorders, adjusting for distal risk factors. We also calculated the total PARP representing the joint effects of all four risk factor domains considering pandemic adverse events−experiences, and the total PARP representing the joint effects of all five proximal risk factor domains, adjusting for distal risk factors.

Estimated prevalence of any 30-day STB was 4.5% in the total sample, 9.7% among the 34.3% of respondents with prepandemic lifetime mental disorders and 1.8% among the 65.7% without any pre-pandemic lifetime mental disorder (Table 1; see online Supplementary Table 2 for unweighted and unimputed estimates). Around 40% of those reporting any 30-day STB reported active suicidal ideation, plans or attempts (1.8% in total); five respondents (0.1%) reported a suicide attempt. Sample characteristics are shown in Table 2 (columns 2 and 3; see online Supplementary Table 3 for unweighted and unimputed estimates). STB estimates stratified by distal risk factors and current mental disorders are shown in online Supplementary Table 4 .

Bivariable associations of socio-demographic variables and number of physical health conditions with STB are shown in Table 2 . Risk factors consistently associated with all three STB outcomes were pre-pandemic level of income (OR = 0.9), having work (ORs = 0.3-0.5) and having three or more physical health conditions (ORs = 3.9-5.3). Unique associations with active suicidal ideation, plan or attempt included being aged 30 or more (ORs = 0.3-0.5), being single (OR = 2.2), being divorced or legally separated (OR = 3.0) and living with a partner (OR = 0.3). Unique associations with passive suicidal ideation included being female (OR = 2.5), being widowed (OR = 2.2), having elderly persons or persons with a disability in care (OR = 1.9) and having exactly two physical health conditions (OR = 4.0).

Adjusted associations of pre-pandemic lifetime mental disorders with STB are shown in Table 3 (see online Supplementary  Table 5 for unadjusted analyses). Almost all pre-pandemic disorders were significantly associated with all three STB outcomes (ORs = 2.7-21.0; PARPs = 2.8-48.7%), including comorbidity of disorders (ORs = 6.2-10.9; PARPs = 31.2-56.1%). Associations were generally stronger with active suicidal ideation, plan or attempt than with passive ideation only. Individual-level impact was particularly high for bipolar disorder (ORs = 9.3-21.0) while population-level impact was highest for depression and anxiety (PARPs = 33.9-48.7%). About 49.1% of any STB is potentially attributable to the joint effects of all pre-pandemic lifetime mental disorders.

Adjusted associations of proximal risk factors with 30-day STB are presented in Table 4 (see online Supplementary Table 6 for unadjusted analyses). Almost all current mental disorders were significantly associated with all three STB outcomes (ORs = 3.3-11.7; PARPs = 5.9-58.2%), including comorbidity of disorders (ORs = 9.4-36.5; PARPs = 40.7-68.7%). Considering personal healthrelated factors, we found that the perceived inefficiency of protective equipment at work was consistently associated with STB (ORs = 1.7-2.0; PARPs = 6.5-6.6%), while personal health-related stress was uniquely associated with active suicidal ideation, plan or attempt (OR = 1.7; PARP = 52.6%). Factors related to the health of loved ones were uniquely associated with were also associated with active suicidal ideation, plan or attempt. No significant associations were found with financial factors. Interpersonal stress was consistently associated with STB (ORs = 1.4-1.9; PARPs = 30.7-50.0%) while lack of social support was uniquely associated with active suicidal ideation, plan or attempt (OR = 2.6; PARP = 68.3%). Table 5 shows that large proportions of any 30-day STB are potentially attributable to interpersonal factors (total PARP = 62.4%), followed by current mental disorders (total PARP = 58.4%), factors related to the health of loved ones (total PARP = 42.2%) and to personal health (total PARP = 34.2%). Up to 69.7% of any STB is potentially attributable to the joint effects of pandemic adverse events-experiences, while up to 74.1% of STB is potentially attributable to the joint effects of all five proximal risk factor domains. Except for the health of loved ones domain, all risk factor domains were more strongly associated with active suicidal ideation, plan or attempt, than with passive suicidal ideation.

Using data from a representative sample of general adults, 30-day prevalence of STB during the first wave of the Spain COVID-19 pandemic was estimated at 4.5%. Population-level impact analysis of risk factors showed that approximately three quarters of STB is potentially attributable to mental disorders and adverse events −experiences related to the pandemic, including health-related stress, lack of social support and interpersonal stress. Above all, these findings highlight the need for interventions that increase access to adequate mental healthcare. Several limitations of this study need mentioning. First, the lack of a pre-pandemic reference point of STB precludes direct pre−post comparisons of STB prevalence. Second, the observational cross-sectional study design limits causal inference of the identified associations of risk factors with STB. Prospective studies are needed, which could also use a structural approach (e.g. direct acyclic graphs) to control for as much confounding as possible according to prior causal knowledge without introducing overadjustment bias. Third, poststratification weights were based on three sociodemographic variables only, and the survey cooperation rate was low (16.5%), which could have led to non-response bias. Scarce evidence from previous studies suggests that mental disorders are higher among survey non-respondents (Kessler et al., 1994) , suggesting underestimation of STB in our study. Fourth, the assessment of mental disorders relied on self-report screener scales (current disorders) and a CIDI checklist (prepandemic lifetime disorders); it should be stressed that this assessment is inferior to face-to-face clinical assessments.

Thirty-day STB prevalence in this study (4.5%; about 1 in 22 adults) is substantially higher than reliable 12-month estimates in the pre-pandemic Spanish population (0.7-0.9%; Miret et al., 2014) , even though lower than in representative population-based studies in other countries conducted during the COVID-19 pandemic: the Czech Republic (11.9%; Winkler et al., 2020) , the UK (8.2-18.0%; Iob et al., 2020; O'Connor et al., 2020) and the US (4.6-15%; Bryan et al., 2020; Czeisler et al., 2020; Fitzpatrick et al., 2020; Gratz et al., 2020; Ammerman et al., 2021) . Pre-pandemic studies also documented higher 12-month STB prevalence in countries such as the US (4.3%; SAMHSA, 2018) and the UK (5.4%; APMS, 2014) v. Spain. Apart from methodological differences (e.g. different STB measures), higher degrees of collectivism in Spain are likely to explain the lower STB in Spain relative to other countries (Eskin et al., 2020) .

Despite our study lacking a direct pre-pandemic reference point of STB prevalence, two observations suggest a potential increase of STB during the pandemic. First, although ∼75% of all STB was found among the roughly one-third of the population with a pre-pandemic history of psychopathology, STB among respondents without pre-pandemic mental disorders was substantial, i.e. 1.8%. Second, we found that 74.1% of STB is potentially attributable to mental disorders and adverse events−experiences related to the pandemic. This estimate is in line with the PARP that can be indirectly calculated when comparing the prepandemic STB estimate from Miret et al. (2014) , i.e. 0.7-0.9%, with our STB estimate of 4.5%, i.e. PARP = (4.5−[0.7-0.9])/4.5 = 80.0-84.4% (Fleiss, 1979) . Since no data on suicides during the Spain COVID pandemic are currently available, it is Total PARP c 49.1 (5.4)* 48.3 (6.9)* 55.0 (8.5)* Abbreviations: OR = odds ratio; CI = confidence interval; PARP = Population Attributable Risk Proportion; S.E. = standard error; STB = suicidal thoughts and behaviours. a Number of observations (n) are unweighted; proportions (%, S.E.) are weighted. b Adjusted models were used, i.e. a separate logistic regression model was created for each type of pre-pandemic lifetime mental disorder and for the number of pre-pandemic lifetime mental disorders, each time adjusting for sociodemographic variables and for number of physical health conditions. c Total PARP considers the joint effects of type and number of pre-pandemic lifetime mental disorders, i.e. a model including seven dummy variables indicating the seven types of disorders plus one dummy variable indicating having two or more disorders, adjusting for sociodemographic variables and for number of physical health conditions. * Indicate statistically significant results (α = 0.05); for PARP, statistical significance is based on the percentile bootstrap confidence interval. 6 P. Mortier et al. 

Positive screens for current mental disorders

Major depressive disorder 407 11.2 (0.5) 6.0 (4.1-8.8)* 39.2 (5.0)* 3.8 (2.4-6.1)* 27.4 (6.7)* 11.7 (6.5-20.8)* 58.2 (7.4)* Generalised anxiety disorder 395 10.9 (0.5) 5.6 (3.8-8.1)* 36.3 (4.8)* 3.7 (2.3-5.9)* 25.4 (6.6)* 10.5 (5.9-18.7)* 54.0 (7.6)*

Post-traumatic stress disorder 342 9.5 (0.5) 4.6 (3.1-6.8)* 26.6 (4.3)* 4.2 (2.6-6.8)* 25.7 (5.5)* 4.8 (2.7-8.5)* 28.1 (7.2)* Panic attacks 357 9.8 (0.5) 6.7 (4.5-10.0)* 36.6 (4.6)* 5.2 (3.2-8.5)* 29.9 (6.0)* 8.9 (4.9-16.2)* 47.3 (7.8)*

Alcohol or substance use disorder 

Significant income loss or (temporarily) unemployed due to COVID-19 1445 39.8 (0.8) 1.1 (0.7-1.5) 1.9 (6.9) 1.2 (0.8-1.9) 6.7 (8.9) 0.9 (0.5-1.6) Adjusted models were used, i.e. a separate logistic regression model was created for each proximal risk factor, each time adjusting for distal risk factors. * Indicate statistically significant results (α = 0.05); for PARP, statistical significance is based on the percentile bootstrap confidence interval.

impossible to investigate whether the potential increase in STB that our study suggests is reflected in increased suicide rates. Studies from other countries suggest that suicide rates either remained unchanged during the first wave of the pandemic (e.g. Greece, Vandoros et al., 2020; the US, Faust et al., 2021; Australia, Coroners Court of Victoria, 2020; China, Qi et al., 2020) or decreased (e.g. Norway, Qin and Mehlum 2020; the UK, Office for National Statistics, 2020; Germany, Radeloff et al., 2021; Peru, Calderon-Anyosa and Kaufman 2021) . A recent study from Japan found evidence for the so-called honeymoon effect, i.e. a delayed increase in suicide rates after an initial drop (Tanaka and Okamoto, 2021) . Taken together, this warns for the adverse effects of the pandemic on current and future population mental health and urges policy makers to implement effective prevention intervention strategies (Moutier, 2020) . The strong associations of mental disorders and interpersonal factors with pandemic STB that our study documented are in line with pre-pandemic studies: a meta-analysis on STB risk factors in the general European population found a pooled OR = 7.4 for affective disorders, OR = 4.3 for anxiety disorders, OR = 1.5-2.5 for substance use and OR = 2.6 for low social support. Our findings also confirm pandemic STB studies that found health-related worries a significant risk factor (e.g. OR = 1.43 with 30-day suicide risk; Winkler et al., 2020) . We now show that both stress about personal health and the health of loved ones is associated with 30-day STB. In contrast to previous studies (Gratz et al., 2020; Iob et al., 2020; Winkler et al., 2020) , however, no significant associations were found with having a COVID-19 diagnosis or with financial factors. Given the scarce evidence available to date, more research is needed on the relationship between adverse events−experiences related to the pandemic and STB.

Our findings support recently proposed prevention frameworks targeting adverse mental health during and after the COVID-19 pandemic (Gunnell et al., 2020; Moutier, 2020; Wasserman et al., 2020) . Above all, the results urge policy-makers to increase access to adequate mental healthcare in Spain, even during this time of healthcare system overload. The fact that nearly one out of 20 Spanish adults screened positive for STB points to the need for multi-stage routine suicide risk screening programmes in healthcare systems (Bahraini et al., 2020) , and for augmenting the availability of crisis response helplines, safety planning and evidence-based treatments for STB (Gunnell et al., 2020; Moutier, 2020; Wasserman et al., 2020) . In addition, one out of four Spanish adults screened positive for current mental disorders and roughly 58% of STB is potentially attributable to these disorders. Our findings also suggest an important role of pre-pandemic mental disorders with roughly 49% of STB being potentially attributable to disorders with onset before the pandemic. Given the high population-level burden these findings indicate, innovative methods such as remote tele-mental health services (Wasserman et al., 2020) or E-health interventions (Torok et al., 2020) are needed to support and complement traditional mental healthcare, not only during the pandemic, but also beyond (Vieta et al., 2020) .

Our study also highlights the need for interventions supporting interpersonal relationships in the population. In line with previous research on prosocial behaviour under stress (Barzilay et al., 2020) , stress related to the health of loved ones was higher than personal health-related stress, and having loved ones infected with COVID-19but not a personal COVID-19 infectionwas strongly associated with STB. Furthermore, we found that tackling interpersonal stress and lack of social support in the population could potentially reduce STB up to ∼62%. Taken together, these findings support previous calls (Gunnell et al., 2020; Moutier, 2020; Wasserman et al., 2020) to increase community-level support for those living alone, to enable regular (digital) check-ins by relatives and friends, to provide access to support by those experiencing health-related stress, family problems or domestic violence, as well as to implement public health strategies to promote stress resilience and cohesion. In conclusion, our findings together with emerging evidence worldwide call for a strong coordinated response from policy-makers, health care Data. The de-identified participant data as well as the study protocol, statistical analysis plan and data dictionaries used for this study are available as from publication and upon reasonable request from the corresponding author (PM; pmortier@imim.es) as long as the main objective of the data-sharing request is replicating the analysis and findings as reported in this paper (without investigator support), after approval of a proposal and with a signed data access agreement.

Acknowledgements. The authors would like to sincerely thank Puri Barbas and Franco Amigo for the management of the MINDCOVID project.

Financial support. Conflict of interest. EV reports personal fees from Abbott, personal fees from Allergan, personal fees from Angelini, grants from Novartis, grants from Ferrer, grants and personal fees from Janssen, personal fees from Lundbeck, personal fees from Sage, personal fees from Sanofi, outside the submitted work. In the past 3 years, RCK was a consultant for Datastat, Inc, Sage Pharmaceuticals and Takeda. VPS has been a consultant to or has received honoraria or grants from AB-Biotics, AstraZeneca, Bristol-Myers-Squibb, CIBERSAM, FIS-ISCIII, Janssen Cilag, Lundbeck, Otsuka, Servier and Pfizer. All other authors reported no conflict of interest.

Ethical standards. The authors assert that all procedures contributing to this study comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2000.

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Preliminary investigation of the association between COVID-19 and suicidal thoughts and behaviors in the U

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Associations among state-level physical distancing measures and suicidal thoughts and behaviors among U.S. adults during the early COVID-19 pandemic

Impact of COVID-19 lockdown policy on homicide, suicide, and motor vehicle deaths in Peru

Determinants of suicidality in the European general population: a systematic review and meta-analysis

Changing the direction of suicide prevention research

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Community mental health profile as tool for psychiatric prevention

Exemplification of a method for scaling life events: the Peri Life Events Scale

Is individualism suicidogenic? Findings from a multinational study of young adults from 12 countries

Suicide deaths during the COVID-19 stay-at-home advisory in Massachusetts

How bad is it? Suicidality in the middle of the COVID-19 pandemic

Inference about population attributable risk from crosssectional studies

Risk factors for suicidal thoughts and behaviors: a meta-analysis of 50 years of research

Thwarted belongingness and perceived burdensomeness explain the associations of COVID-19 social and economic consequences to suicide risk

Screening for drug and alcohol abuse among older adults using a modified version of the CAGE

Abuse, self-harm and suicidal ideation in the UK during the COVID-19 pandemic

The World Mental Health (WMH) survey initiative version of the World Health Organization (WHO) Composite International Diagnostic Interview (CIDI)

Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey

Clinical reappraisal of the Composite International Diagnostic Interview Screening Scales (CIDI-SC) in the Army Study to Assess Risk and Resilience in Service members (Army STARRS)

The PHQ-8 as a measure of current depression in the general population

The struggle to prevent and evaluate: application of population attributable risk and preventive fraction to suicide prevention research

MIND/COVID-19. Mental health Impact and NeeDs associated with COVID-19: a comprehensive national evaluation in Spain

Factors associated with suicidal ideation and attempts in Spain for different age groups. Prevalence before and after the onset of the economic crisis

Suicide prevention in the COVID-19 era: transforming threat into opportunity

Preliminary reliability and validity of the generalized anxiety disorder questionnaire-IV: a revised selfreport diagnostic measure of generalized anxiety disorder

Suicide. Global Perspectives From the WHO World Mental Health Surveys

The integrated motivational-volitional model of suicidal behaviour

Mental health and well-being during the COVID-19 pandemic: longitudinal analyses of adults in the UK COVID-19 Mental Health & Wellbeing study

The Columbia-suicide severity rating scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults

Do Lockdowns Bring about Additional Mortality Benefits or Costs? Evidence based on Death Records from 300 Million Chinese People

National observation of death by suicide in the first 3 months under COVID-19 pandemic

Quarterly Suicide Death Registrations in England

Trends in suicide rates during the COVID-19 pandemic restrictions in a major German city. Epidemiology and Psychiatric Sciences

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Prevalence of passive suicidal ideation in the early stage of the coronavirus disease 2019 (COVID-19) pandemic and lockdown in a large Spanish sample

The selfadministered comorbidity questionnaire: a new method to assess comorbidity for clinical and health services research

SAS® Software

Overadjustment bias and unnecessary adjustment in epidemiologic studies

Clarifying questions about "risk factors": predictors versus explanation

Key Substance use and Mental Health Indicators in the United States: Results From the 2018 National Survey on Drug Use and Health

Increase in suicide following an initial decline during the COVID-19 pandemic in Japan

Suicide prevention using self-guided digital interventions: a systematic review and meta-analysis of randomised controlled trials

Flexible Imputation of Missing Data

No evidence of increase in suicide in Greece during the first wave of Covid-19

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COVID-19 pandemic and mental health consequences: systematic review of the current evidence

Adaptation of evidence-based suicide prevention strategies during and after the COVID-19 pandemic

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Increase in prevalence of current mental disorders in the context of COVID-19: analysis of repeated nationwide cross-sectional surveys

Developing an optimal short-form of the PTSD checklist for DSM-5 (PCL-5)