key: cord-0952702-4als30xg
authors: Messina, F.; Piaserico, S.
title: SARS‐CoV‐2 infection in a psoriatic patient treated with IL‐23 inhibitor
date: 2020-04-15
journal: J Eur Acad Dermatol Venereol
DOI: 10.1111/jdv.16468
sha: 5de1862f9c6bbddfd7b8185588885c3b72a272fa
doc_id: 952702
cord_uid: 4als30xg

Since December 2019, an outbreak of 2019 novel coronavirus disease (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been spreading worldwide. This has risen concern among patients undergoing biologics and physicians who administer them, as far as the possible increase of incidence and severity of COVID‐19 in this delicate population concerns.

This article is protected by copyright. All rights reserved Since December 2019, an outbreak of 2019 novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading worldwide. This has risen concern among patients undergoing biologics and physicians who administer them, as far as the possible increase of incidence and severity of COVID-19 in this delicate population concerns 1 .

We describe the case of a 32-year-old woman, affected by psoriasis and psoriatic arthritis since 18 years, previously treated with several conventional and biologic drugs, including cyclosporine, methotrexate, infliximab, etanercept, adalimumab, secukinumab and ixekizumab. She had no other medical conditions. In April 2019 she developed a severe Crohn's disease while taking ixekizumab. Therefore, she switched to ustekinumab, with improvement of Crohn's disease but a worsening of both psoriasis and psoriatic arthritis. On 6 th November, we added methotrexate 10 mg/week, which was further increased to 25 mg/week after 4 weeks because of an unsatisfactory response. On 23 rd December, since psoriasis was still worsening, we switched ustekinumab to guselkumab, while maintaining methotrexate at 25 mg/week. On February 26 th , after two injections of guselkumab the patient showed a marked improvement of psoriasis and arthritis.

On February 29 th , she went out for dinner with some friends and, 2 days later, one of them was discovered to be affected by COVID-19. On March 4 th she had mild rhinorrhea and fever (37.4 °C) and the next day she was tested positive for SARS-CoV-2.

The day after the body temperature lowered to 36.3 °C and the rhinorrhea was still mild. We advised her to interrupt methotrexate and to postpone the next guselkumab injection, which was originally scheduled for March 16 th .

In the following days, the body temperature never rose above 36,5 °C and she never developed sore throat, cough, shortness of breath or other symptoms of the infection. Her blood tests revealed increased erythrosedimentation rate (120 mm/h), C-reactive protein (4,76 mg/dL), D-dimer (381 ug/L) and fibrinogen (701 mg/dL). All the other parameters were normal.

This article is protected by copyright. All rights reserved On March 13 th the rhinorrhea subsided. On March 20 th RT-PCR was still positive for SARS-CoV-2. On March 28 th and March 30 th the tests resulted negative, meeting the criteria to be considered successfully healed.

In COVID-19, inflammatory cytokines assume a double role: firstly, they stimulate the activation of an effective immune response, while later they can mediate the development of an exaggerated systemic inflammation. This "cytokine storm" is both ineffective toward the pathogen and detrimental for the body, eventually leading to acute respiratory distress syndrome and potentially to death 2 .

Available data suggest that the adaptive response toward SARS-COV-2 develops mainly in a Th1 polarized fashion, being CD8+ cytotoxic cells the main effectors of the antiviral response 2 . With the progression of the disease, the worsening of clinical conditions is associated to a marked increase in proinflammatory cytokines, such as IL-1, IL-6 and TNF alfa 2,3 .

Interestingly, the IL-23/IL-17 axis does not seem to be pivotal in an effective immune response.

On the contrary, observations carried on both coronavirus and non-coronavirus pneumonia patients show that an aberrant Th17 polarization may correlate with a worse outcome 4,5 .

Based on these observations, a clinical trial investigating the use of ixekizumab associated to antiviral therapy is currently ongoing in China as a possible treatment for COVID-19 infection 6 .

In conclusion, we reported the first case of COVID-19 infection in a psoriatic patient treated with a biologic. The outcome of this case and data from currently available literature suggest that IL-23/IL-17 axis inhibition might not be detrimental in the setting of COVID-19 infection. Further data are needed to support this hypothesis.

Should biologics for psoriasis be interrupted in the era of COVID-19?

Research progress on the mechanism of cytokine storm induced by new coronavirus pneumonia and related immunotherapy

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside?

Critical role of IL-17RA in immunopathology of influenza infection

Chinese Clinical Trial Register

Ministry of Health (China)

A randomized, blinded, controlled, multicenter clinical trial to evaluate the efficacy and safety of Ixekizumab combined with conventional antiviral drugs in patients with novel coronavirus pneumonia (COVID-19)

The patient in this manuscript has given written informed consent to publication of her case details

This article is protected by copyright. All rights reserved