key: cord-0952663-rrgb2rnd authors: Wilson, William; Raj, Jeffrey Pradeep; Rao, Seema; Ghiya, Murtuza; Nedungalaparambil, Nisanth Menon; Mundra, Harshit; Mathew, Roshan title: Prevalence and Predictors of Stress, anxiety, and Depression among Healthcare Workers Managing COVID-19 Pandemic in India: A Nationwide Observational Study date: 2020-07-06 journal: Indian J Psychol Med DOI: 10.1177/0253717620933992 sha: 4550419d4fd3095c0c548b01e1517a21d40f12e4 doc_id: 952663 cord_uid: rrgb2rnd BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has caused great financial and psychological havoc. Healthcare professionals (HCPs) are among the many groups of people who are in the frontline and facing a risk of direct exposure to the virus. This study aimed to assess the prevalence and predictors of stress, depressive, and anxiety symptoms among HCPs of India. METHODS: It was a cross-sectional, online survey conducted in April 2020 among HCPs who are directly involved in the triage, screening, diagnosing, and treatment of COVID-19 patients and suspects. Stress was estimated using Cohen’s perceived stress scale. Depression and anxiety were assessed using the tools Public Health Questionnaire—9 and Generalized Anxiety Disorder—7. Predictors were analyzed using univariate and multivariate binary logistic regression. RESULTS: A total of 433 online responses were obtained, and N = 350 were finally included. The prevalence (95% CI) of HCPs with high-level stress was 3.7% (2.2, 6.2), while the prevalence rates of HCPs with depressive symptoms requiring treatment and anxiety symptoms requiring further evaluation were 11.4% (8.3, 15.2) and 17.7% (13.9, 22.1), respectively. Women had approximately two times the increased odds of developing moderate- or high-level stress, depressive symptoms requiring treatment, and anxiety symptoms requiring further evaluation. Similarly, women staying in a hostel/temporary accommodation had two times the increased odds of developing depression or anxiety symptoms. CONCLUSION: The prevalence of stress, depressive, and anxiety symptoms among HCPs in India during the pandemic is comparable with other countries. world, with numbers increasing by the day. 1 This has put healthcare professionals (HCP) under tremendous pressures as they deal with many variables some of which are longer working hours, lack of personal protective equipment, lack of specific drugs and protocols, and being away from family. According to previous studies, during the outbreaks of severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS), frontline medical staff had reported high levels of stress that resulted in posttraumatic stress disorder (PTSD). 2, 3 It was also found that HCPs considered resignation, faced stigmatization, 4 and feared contagion and spread to family and friends, resulting in high levels of stress, depression, and anxiety symptoms. 5 There have been plenty of reports from China detailing the number of HCPs getting infected and even succumbing to the illness. 6 Concerns of the psychological impact of the pandemic like before are arising. This resulted in interventions such as setting up psychological assistance services over the telephone, internet, and application-based sessions. As on April 11, 2020, India faces the most critical phase of the pandemic, with community transmission not yet in full flow. 7 HCPs across the country are facing a fight like never before. Vulnerable to psychological impact, we aim to evaluate the magnitude of stress, anxiety, and depression and to assess possible associated risk factors at this early stage of the pandemic. This would help us plan appropriate interventions at the early stage to prevent a detrimental outcome for the brave HCPs out there. The study was approved by the institutional ethics committee. An online written informed consent was obtained from all potential participants. This was an online-questionnaire-based cross-sectional study conducted in India during the month of April 2020.The online questionnaire was designed on Google Forms and circulated in multiple WhatsApp groups, targeting doctors and nurses involved in triage, screening, diagnosing, and treatment of COVID-19 patients and suspects. Those who were currently doing their internship were excluded. The link to the online questionnaire was circulated on April 10, 2020, and the target sample size was achieved on April 25, 2020. A maximum of three reminders were sent in all WhatsApp groups. To limit the number of HCPs who inadvertently answer the questionnaire without being involved in COVD-19 work, a specific yes/no question confirming their work in COVID-19 was asked. Those who marked the answer as "Yes" were allowed to continue answering the questionnaire. The questionnaire had five sections, namely, baseline sociodemographic characteristics, Generalized Anxiety Disorder 7-item (GAD-7), Patient Health Questionnaire-9 (PHQ-9), Perceived Stress Scale-10 (PSS-10), and miscellaneous psychosocial questions. Data were collected anonymously, with only one response was permitted per person. PHQ-9 is a 9-item self-report questionnaire used in clinical practice for screening, diagnosing, monitoring, and measuring the severity of depression. PHQ scores ≥10 have a sensitivity of 88% and a specificity of 88% for major depression and require treatment. 8 PSS-10 is an instrument designed to measure the degree to which situations in one's life are appraised as stressful. PSS items have been found to have good correlations with other stress measures, self-reported health and health service measures, health behavior measures, smoking status, and help-seeking behavior. 9 GAD-7 is a 7-item self-report questionnaire used in clinical practice for screening and assessing severity of generalized anxiety disorder. Cut-off points of 5, 10, and 15 may be interpreted as representing mild, moderate, and severe levels of anxiety on the GAD-7. A score of >10 would require further evaluation. 10 Considering an estimated prevalence of depression (p) among HCPs to be 13.5% based on the study by Zhu et al., 11 the sample size estimated using the formula (Zα) 2 pq/d 2 using an alpha error of 5% and an absolute precision (d) of 5% was 179. If estimated considering the prevalence of stress (p = 29.8%), although a different tool being used, and anxiety (p = 24.1%), the sample size, with the other assumptions remaining constant, would be 322 and 281, respectively. Considering the largest value among the three and assuming an approximate 10% of questionnaires to have incomplete responses, we decided to increase the sample size to 350. Data were exported from the Google Demographic characteristics were summarized using descriptive statistics such as frequency and percentages in case of discrete data, or mean and standard deviation (SD) in the case of continuous data. Prevalence rates of high-level stress, anxiety symptoms requiring further evaluation, and depressive symptoms requiring treatment were expressed as proportions with 95% confidence intervals (CI). The hypothesized factors/predictors to each of these conditions, namely stress, anxiety, and depression, such as age, gender, being a doctor, years of experience, hostel/ temporary accommodation, history of mental illness, presence of comorbidities, perceived inability to distress, and employment in the government sector, were subjected to univariate binary logistic regression. Those with a significance of P < 0.2 in the univariate analysis were included in the multivariate binary logistic regression model. A total of 433 responses were received. Of these, 83 respondents were not involved in any of the COVID-19 related activities and hence were excluded. The remaining 350 from across ten states and one union territory were included in the analysis. A total of 344 participants had disclosed their institutions of affiliation, and the number of participating institutions totaled to 98. Of the 350 participants, 84.3% (n = 295/350) were doctors and the remaining 15.7% (n = 55/350) were nurses. The mean (SD) age of the participants was 30.21 (5.22) years. The demographic characteristics are summarized in Table 1 . The details regarding the occupation of participants are given in Table 2 . Junior residents formed the major proportion (n = 168/350; 48.0%). The mean (SD) years of experience of the participants were 5.52 (4.79). The prevalence (95% CI) of HCPs with high-level stress was 3.7% (2.2, 6.2). The prevalence rates (95% CI) of HCPs with depressive symptoms requiring treatment and anxiety symptoms requiring further evaluation were 11.4% (8.3, 15.2) and 17.7% (13.9, 22.1), respectively. The details of various categories of stress, depressive symptoms, and anxiety symptoms, and the details of leisure activities are depicted in Table 3 . A large majority (n = 273/350; 78.0% had serious concerns about the spread of infection from them to their friends or family members. Also, most participants (n = 151/350; 43.2% and n = 175/350; 50.0%, respectively) were not satisfied with the administrative support from the institution and the availability of personal protective equipment. An analysis to identify the predictors of moderate-and high-level stress revealed that female gender (odds ratio [OR] = 2.008, 95% CI = 1.122, 3.594, and P value = 0.019) was the only significant predictor among all the hypothesized factors, thereby negating the need for multivariate analysis. With regards to depressive symptoms requiring treatment, the significant predictors (adjusted OR; 95% CI; P value) were female gender (2.023; 1.021, 4.010; 0.044) and hostel/temporary accommodation (2.355; 1.180, 4.702; 0.015). Similarly, the significant predictors (ad-justed OR; 95% CI; P value) of anxiety symptoms requiring further evaluation were female gender (2.180; 1.230, 3.862; 0.008) and hostel/temporary accommodation (1.926; 1.046, 3.548; 0.035). The details of the univariate analysis and multivariate analysis to identify the predictors of stress, depression, and anxiety are summarized in Table 4 . The prevalence of high-level stress was low (3.7%) and the rates for depressive symptoms requiring treatment and anxiety symptoms requiring further evaluation (11.4% and 17.7%, respectively) were comparatively more. The prevalence rates of depressive and anxiety symptoms are in line with the findings from similar studies assessing psychological impact during the COVID-19 pandemic in China but the prevalence of high-level stress in our study is comparatively low. However, a huge majority of our participants still have moderately-high stress (78.9%), which is clinically relevant. Zhu et al. from Wuhan, China, the epicenter of the virus outbreak, have reported that among 5,062 HCPs, the prevalence rates of stress, depression, and anxiety were 29.8%, 13.5%, and 24.1%, respectively. 11 Another study from China, conducted among 1,257 HCPs, reported that the prevalence rates of severe distress, depressive symptoms requiring treatment, and anxiety symptoms requiring further evaluation were 10.5% (n = 132/1257), 14.8% (n = 186/1257), and 13.3% (n = 154/1257), respectively. 12 To the best of the authors' knowledge, as on April 20, 2020, study results from India or other countries on the psychological impact of COVID-19 among HCPs are yet to be published. A closer look into the baseline prevalence of stress, depression, and anxiety among medical staff revealed similar prevalence rates even without the pandemic. A study by Grover et al. among doctors from Chandigarh, conducted in the pre-pandemic period, has reported the prevalence of moderate or severe depression to be 13.2% (n = 59/445) and moderate-or high-level stress to be 80.2% (n = 357/445), using the same tools used by us. 13 Swapnil et al. have reported that the prevalence rates of anxiety Greater than ten years 40 11.4 and depression were 64.60% and 14.18% as assessed using the 28-item general health questionnaire. 14 This suggests that the pandemic has not overtly affected the psychological well-being of the HCPs in India. One possible reason could be that the community transmission is in check due to the ongoing nationwide lockdown, thereby reducing the patient load. 15 Another factor could be resilience that Indian doctors might have developed during the course of their professional life. 16 Medical post-graduate training in India is very competitive, 17 usually very vigorous, and with long working hours, 18 associated burnout, and routine exposure to a variety of infectious diseases. 19 Furthermore, even without a pandemic, the public sector hospitals in India always see a huge number of cases, with very limited staff and infrastructure. 20 Exposed to such stressors, the attitude of HCPs to the current crisis could be paradoxically less panic-stricken. Although we discuss that the psychological issues are not much different now when compared to the non-pandemic days, the concern of spreading the infection to family and friends and the concern about lack of administrative support and adequate personal protective equipment is very high as noted in HCPs across the world. 21 An analysis of the risk factors for stress, depression, and anxiety symptoms revealed that female gender was a significant predictor. Women were at approximately two times higher odds to develop these conditions. This finding is in line with the findings reported by Lai et al., where women are at increased odds of developing distress (OR: 1.45; P = 0.01), depression (OR: 1.94; P = 0.003), and anxiety (OR: 1.69; P = 0.001). 12 Staying at a hostel or other temporary makeshift accommodations was yet another significant predictor, with participants at two-times the increased odds of developing depression or anxiety symptoms. Those living away from home are most likely feeling lonely, which itself is an important risk factor for psychiatric symptoms. 22 Female gender is yet another risk factor for the development of psychiatric symptoms during loneliness. 22 studies from other countries have identified many other predictors of psychological symptoms, 12, 21 we believe that the resilience developed during the early days of the professional career, as discussed, have helped Indian HCPs to tide over the psychological crisis the pandemic otherwise would have created. Our study has a few limitations. By virtue of its design that it is an online questionnaire without face-to-face interviews, it is difficult to pin a clinical diagnosis on participants who exhibited symptoms. The actual prevalence rates of clinically diagnosed psychological issues studied may vary, although validated screening tools have been used in this study. Also, self-selection bias is a possibility. Further, not all cadres of HCPs other than nurses and doctors have participated in the study. Yet another limitation is that India being a large country in area, the burden of patients diagnosed with COVID-19 is varied, with metros facing the brunt of the pandemic rather than the interiors. Thus, the findings may not be truly reflective of the entire nation during the time of this study. Having said that, the main strength of this study is that the psychological impact has been assessed while the trigger event is actually still ongoing and the threat is still looming. The prevalence rates of high-level stress, depressive symptoms requiring treatment, and anxiety symptoms requiring further evaluation were 3.7%, 11.4%, and 17.7%, respectively. These were comparable to the reports from other countries. Female gender and staying away from family were significant predictors. The government of India has already been taking a lot of initiatives to cater to the psychological needs of the general population and its HCPs, and we recommend that these measures continue to be in place at least till the pandemic completely phases out itself. 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