key: cord-0952371-clibve0h authors: Fjordside, Lasse; Mens, Helene; Asmar, Ali title: Using (18)F-FDG PET/CT to rule out Richter transformation as cause of deterioration in a patient with chronic lymphatic leukemia and severe COVID-19: A case report date: 2021-11-05 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000027545 sha: 86ee89b5b1017b0e204727dde37fac29569baf37 doc_id: 952371 cord_uid: clibve0h RATIONALE: This case report demonstrates the use of flourine-18 fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) to rule out Richter transformation (RT) as the cause of clinical deterioration in a patient with chronic lymphatic leukemia (CLL) and severe COVID-19. (18)F-FDG PET/CT can be used to establish the diagnosis of RT in patients with CLL, but the use of (18)F-FDG PET/CT to exclude RT as the cause of clinical deterioration in patients with CLL and severe COVID-19 has not previously been described. PATIENT CONCERNS: A 61-year-old male with CLL and COVID-19 developed increased dyspnea, malaise and fever during hospitalization for treatment of severe and prolonged COVID-19. DIAGNOSES: (18)F-FDG PET/CT ruled out RT and revealed progression of opacities in both lungs consistent with exacerbation of severe acute respiratory syndrome coronavirus 2 pneumonia. INTERVENTIONS: (18)F-FDG PET/CT imaging. OUTCOMES: The patient was discharged at day 52 without the need of supplemental oxygen, with normalized infection marks and continued care for CLL with venetoclax. LESSONS: (18)F-FDG PET/CT ruled out RT as the cause of deteriorations in a patient with CLL and severe COVID-19, enabling directed care of exacerbation of severe acute respiratory syndrome coronavirus 2 pneumonia. Patients with chronic lymphatic leukemia (CLL) are at increased risk of severe COVID-19, likely due to dysfunctional lymphocytes. [1] During the course of severe COVID-19, some patients experience relapses and lack of treatment response. In these situations, distinguishing between hospitals acquired superinfections, relapse of viral replication or immunological hyperactivity as underlying causes is essential when determining the treatment strategy. While this may often proof to be a challenging task in itself, treating patients with CLL and severe Editor: Maya Saranathan. The authors have no funding and conflicts of interest to disclose. The patient provided informed oral and written consent for publication of this case report. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request. All data generated or analyzed during this study are included in this published article [and its supplementary information files]; Data sharing not applicable to this article as no datasets were generated or analyzed during the current study. The datasets generated during and/or analyzed during the current study are not publicly available, but are available from the corresponding author on reasonable request. COVID-19 is further complicated by the risk of Richter transformation (RT) that also has to be considered as the potential cause of sudden deteriorations. RT refers to the change of indolent CLL to aggressive non-Hodgkin lymphoma. [2] Patients typically present with fever (in the absence of infection), progressive lymph node enlargement, and elevated lactate dehydrogenase. The risk of transformation is independent of disease stage, duration or response to prior treatment, and may be triggered by viral infections (eg, Epstein-Barr virus), which are common in immunocompromised patients. [3] Transformation occurs in about 5% to 16% of patients with CLL and has a poor prognosis; median survival with conventional chemotherapy is less than 1 year. [4] Flourine-18 fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging has been used to identify such transformation; the absence of foci with significant 18 F-FDG uptake can exclude the diagnosis of RT with a high degree of confidence, [5] thus 18 F-FDG PET/CT could be a useful tool in ruling out RT in CLL patients with severe COVID-19. A 61-year-old Caucasian male known with a difficult to treat variant of CLL (TP53pos 13q mutated) and accompanying B-cell paresis presented to the ED with fever and general malaise was admitted with a SARS-CoV2 positive pneumonia with the need of 4 L/min nasal oxygen supply. The course of time during hospitalization is shown in Figure 1 . The patient had received treatment with ibrutinib for 6 months before admission, but this had been stopped due to hematuria and subcutaneous bleeding. In addition, the patient had received 2 courses of rituximab, fludarabine, and cyclophosphamide before admission together with intravenous gamma globulin. The patient received treatment with remdesivir (200 mg on day 1 and 100 mg the following days i.v.) [6] and oral dexamethasone (6 mg daily) [7] for 4 days and was discharged due to bettering of respiratory symptoms. However, the patient was readmitted within 24 hours with fever and respiratory deterioration and oxygen need of 10 L/min. He was re-treated with dexamethasone and broad-spectrum antibiotics. Due to respiratory worsening, treatment with dexamethasone was prolonged to a total of 14 days. Convalescence plasma was added on admission day 16 along with a second course of remdesivir of 4 days. On admission day 16, the patient was transferred to the intensive care unit because of further respiratory worsening. Dexamethasone was re-initiated, the patient stabilized respiratory on high-flow oxygen without the need for intubation and was back in the COVID ward admission day 21. Due to continuous fever and increasing inflammatory parameters, itraconazole (200 mg twice daily), convalescence plasma and remdesivir was initiated on day 30. At this point of the admission, transformation of CLL and opportunistic disease were considered as co-factors for not getting better. The patient refused bronchoalveolar lavage and bronchoscopy, however 18 F-FDG PET/CT imaging was carried out (Fig. 2) . PET MIP ( Fig. 2A) and axial fused PET and contrast-enhanced CT images (Fig. 2B ) demonstrated inhomogeneous high 18 F-FDG uptake corresponding to diffuse ground glass and consolidative opacities in both lungs consistent with SARS-CoV2 infection (Fig. 2C ). [8, 9] Nonenlarged mediastinal and iliac lymph nodes with slightly increased 18 F-FDG uptake were also demonstrated and likely related to the patient's CLL. PET/CT images did not reveal any signs of transformation. The 18 F-FDG PET/CT scan allowed clinicians to continue care directed toward progressive pulmonary involvement of SARS-CoV2 infection according to guidelines. The patient adhered to and tolerated the treatments well. The patient was discharged to his own home at day 52 without the need for supplemental oxygen and with normalized blood-works. He continued care for CLL with venetoclax [10] and was enrolled in an outpatient post-COVID follow-up program. Patients with CLL are at increased risk of severe COVID-19 [1] and during the course of disease, patients may experience deteriorations and lack of treatment response. RT can potentially be the cause of such sudden set-backs or lack of treatment response in patients with CLL and severe COVID-19, but distinguishing RT from progression of the severe acute respiratory syndrome coronavirus 2 infection or other opportunistic infections is challenging. The use of 18 F-FDG PET/CT to detect RT in patients with CLL is well established, [5] but the usefulness in excluding RT during severe COVID-19, has not, to our knowledge, been proposed before. Although PET/CT offers no clinically significant additional value in the standard diagnostic management of COVID-19, [11] it should be considered in patients with CLL and deteriorations during standard treatment regimens for severe COVID-19 in order to rule out RT as the cause. As previously described the patient refused bronchoscopy and bronchoalveolar lavage which made ruling out opportunistic infections as cause of the clinical and para-clinical deterioration impossible. Using the cycle threshold value from daily severe acute respiratory syndrome coronavirus 2 PCRs as an invert proxy for viral load was not enrolled in clinical practice in our hospital at the time the case took place, but could potentially have aided the differentiation between COVID-19 progression and other causes for the clinical worsening. This resulted in a more broad and aggressive treatment strategy and thus an increased risk of significant side effects and the obvious loss of a clear therapeutic target making withdrawal of individual treatments more difficult. 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