key: cord-0951849-0wbu1yap
authors: Zhu, Ying; Liu, Yang-Li; Li, Zi-Ping; Kuang, Jian-Yi; Li, Xiang-Min; Yang, You-You; Feng, Shi-Ting
title: Clinical and CT imaging features of 2019 novel coronavirus disease (COVID-19)
date: 2020-03-03
journal: J Infect
DOI: 10.1016/j.jinf.2020.02.022
sha: 24b996db83d4d2622d87fb583e6dc6fa277a636f
doc_id: 951849
cord_uid: 0wbu1yap

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Dear Editor, Tang JW, et al. and colleagues have written to this Journal describing the emergence of 2019 novel coronavirus disease (COVID-19) 1 . We have had an opportunity to examine in detail the chest computed tomography (CT) findings in cases with microbiologically confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to familiarize radiologists and clinicians with the imaging manifestations of this new outbreak. Meanwhile, we also studied the clinical characteristics of the cases, combined with CT manifestations, to provide more clues for the correct diagnosis of the disease.

Six female patients (P1-P6) aged from 27 to 63 years were referred to the fever clinic of our hospital. None of the patients had underlying diseases such as diabetes, malignant tumour or respiratory disease. Among the 6 cases, 5 (P1-P5) had a history of exposure to Wuhan or Hubei, and P6 had no clear epidemiological history. All the patients performed oropharyngeal swabs test and confirmed as COVID-19. Common respiratory viruses, mycoplasma and chlamydia were negative. For patients' venous blood tests at disease onset, as given in (Table 1) , we found that leucocytes, lymphocytes and percentage were slightly decreased or normal, eosinophil count and percentage were slightly decreased in 4 cases and normal in 2 cases. Additionally, 4 days later, P1 reperformed the follow-up hematologic examination. Compared with the blood test at disease onset, the results showed that the eosinophil count was still below the normal range, which was even lower than the first time.

On admission, all patients underwent high resolution chest CT examination and their manifestations were shown in (Table 2 ). P1 (Figure 1 Mild bronchiectasis (P6, A2, arrow) can also be observed within the lesion. indicate the appearance of the corresponding sign.

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