key: cord-0951107-4663t99a
authors: Dhar, Sujan K.; Sachdeva, Kartik; Das, Manjula
title: Inflammation and hypercoagulopathy are predominant risk factors of severity in COVID-19 patients with diabetes mellitus: Summary of a meta-analysis
date: 2021-02-24
journal: Diabetes Metab Syndr
DOI: 10.1016/j.dsx.2021.02.021
sha: e06d5fb190797bc013af5b0640580b511a417401
doc_id: 951107
cord_uid: 4663t99a

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were excluded from analysis due to infrequent ( ≤ 50%) reporting in selected studies. 50

Meta-regression carried out using a mixed-effects model with parameters in each 51 individual category as moderators, showed only three parameters -decrease in 52 lymphocyte count and increase in levels of D-dimer and CRP in DM patients to be 53 associated with statistically significant contribution to risk ratio (Fig. 1) . All other 54 parameters had insignificant contribution (Supplementary Table S2 ). Observed 55 asymmetry in funnel plot for log risk ratio (Supplementary Fig. S2 ) and Egger's test p-56 value (< 0.01) indicate presence of small-study effects. 57

The findings that inflammation, manifested by lymphopenia and increase in serum CRP 58 level is a risk factor for progression to severe COVID-19 illness, is commensurate with 59 maximum loss of lymphocytes observed in DM patients compared to non-DM severe 

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especially T and B subsets closely related to the poor prognosis and the disease 117 severity in severe patients with COVID -19 and diabetes mellitus

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