key: cord-0950040-aaz9tqlg authors: Magoon, Rohan; ItiShri,; Kaur Kohli, Jasvinder; Kashav, Ramesh title: Postoperative inflammation to “hyper”‐inflammation: cryptic COVID‐19 connections! date: 2021-02-25 journal: Paediatr Anaesth DOI: 10.1111/pan.14121 sha: 0bb1b48cc75918914dfc2c91321c1060e4928830 doc_id: 950040 cord_uid: aaz9tqlg nan To The Editor, Over the past few months, a considerable literature has accumulated on the possibility of a multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. 1 Appropriate to this context, we wish to share our experience emanating from a pediatric cardiac surgical setting. To conclude, the aforementioned experience highlights the present-day relevance of a sound perioperative risk comprehension, consent appropriate to the level of planned surgical intervention to be equally backed by a case-based approach for the anticipation, and the attenuation of the second inflammatory hit aimed at ameliorating the overall severity of the postoperative disease. 8, 9 Meanwhile, prudent feasible suggestions from our colleagues on minimizing such perioperative circumstances are more than welcome. Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review Pulmonary vasculature in COVID-19: mechanism to monitoring COVID-19 and congenital heart disease: Cardiopulmonary interactions for the worse! Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: Molecular mechanisms and implications Interpreting a covid-19 test result Screening and testing for COVID-19 before surgery COVID convalescence-a boon or bane in cardiac surgery?: A "Second Hit" hypothesis Inhaled Milrinone for sick COVID-19 cohort: a pathophysiology driven hypothesis Med Hypotheses. 2020 Potential therapeutic value of dexmedetomidine in COVID-19 patients admitted to ICU