key: cord-0948283-cy4kxalx authors: Pinxt, C M H; Bogie, R M M; Hanssen, N M J; Spaetgens, B title: Antibiotic overuse in older patients: an important clinical reminder of pseudomembranous colitis date: 2021-07-16 journal: QJM DOI: 10.1093/qjmed/hcab198 sha: a4403edc38e80c128599811ead72804000ce06bf doc_id: 948283 cord_uid: cy4kxalx nan The CDI was treated with vancomycin and patient recovered swiftly. The aging process itself, malnutrition and antibiotic (over)use may cause a reduction in gut microbial diversity that increases CDI susceptibility. 1, 2 In addition, an emerging body of studies reveal widespread overuse of antibiotics in patients with COVID-19, entailing an increased risk of adverse events, such as CDI. 3, 4 Therefore, this case underlines that perceived benefits of antibiotic prescription, especially in (frail) older patients, may be This is an Open Access article distributed under the terms of the Creative Commons Attribution-onCommercial License (https://creativecommons.org/ licenses/byc/4.0/), which permits nonommercial re-se, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-se, please contact journals.permissions@oup.com Risk factors for Clostridium difficile colonisation and toxin production Older is not wiser, immunologically speaking: effect of aging on host response to Clostridium difficile infections Antibiotic use in patients with COVID-19: a 'snapshot' Infectious Diseases International Research Initiative (ID-IRI) survey for the SEMI-COVID-19 Network. Inappropriate antibiotic use in the COVID-19 era: factors associated with inappropriate prescribing and secondary complications. Analysis of the registry SEMI-COVID Fecal microbiota transplantation in human metabolic diseases: from a murky past to a bright future