key: cord-0945968-s2bzfosg
authors: Natalucci, Valentina; Villarini, Milena; Emili, Rita; Acito, Mattia; Vallorani, Luciana; Barbieri, Elena; Villarini, Anna
title: Special Attention to Physical Activity in Breast Cancer Patients during the First Wave of COVID-19 Pandemic in Italy: The DianaWeb Cohort
date: 2021-05-06
journal: J Pers Med
DOI: 10.3390/jpm11050381
sha: 7c40566f0693b2ab9e925bdd8c1c9b80dc672c17
doc_id: 945968
cord_uid: s2bzfosg

Recent evidence highlights that physical activity (PA) is associated with decreased recurrence risk, improved survival and quality of life for breast cancer (BC) patients. Our study aimed to explore patterns of increased/decreased PA, and sedentary behaviors among BC women of the DianaWeb cohort during the first wave of COVID-19 pandemic, and examined the association with residential locations, work changes, different modality used to increase PA, and quality of life. The study analyzed the questionnaires completed by the 781 BC women (age 54.68 ± 8.75 years on both December 2019 and June 2020. Results showed a decrease of 22%, 57%, and 26% for walking activity, vigorous activity, and total PA, respectively. Sitting/lying time increased up to 54.2% of the subjects recruited. High quality of life was associated with lower odds of being sedentary (p = 0.003). Our findings suggest that innovative health management fostering compliance with current guidelines for PA and active behavior should be implemented, especially in unpredictable emergency conditions.

Physical activity (PA) and exercise for breast cancer (BC) patients and survivors are emerging key elements in the oncological prevention spectrum. In this regard, exercise oncology (i.e., exercise medicine in the management of cancer) represents an important option for patients during rehabilitation, aftercare, and survival [1] , with the aim of making the patient more active in everyday life. A growing body of literature shows the positive influence of PA and exercise on the reduction of recurrence and mortality [2, 3] . Additionally, exercise can have a favorable impact on cancer-and treatment-related side effects (including fatigue, depression, and physical functioning) and quality of life (QoL) of cancer survivors. However, there are differences in outcomes depending on clinical setting of the BC patients and functional factors related to exercise, such as type, intensity, and activity level. Indeed, there is a positive correlation between high level of cardiorespiratory fitness and probability of survival [4] , however, a high level of activity is not necessarily associated with the best QoL [5] . Ultimately, it is important to meet the stated American College of Sports Medicine (ACSM) recommendations on the basis of BC patient's health status [6] . Indeed, current guidelines recommend people who have been treated for cancer to "avoid inactivity" and self-reported questionnaires on PA levels assessed by International Physical Activity Questionnaire Short Form (IPAQ-SF) [18, 19] , and (b) medical history. Participants also provided demographic information, anthropometric data (body weight, body height, and waist circumference), results of routine biochemical analysis, and clinical information (histology report and hospital discharge letters, and any other subsequent diagnosis). Volunteers can also make use of a private chat, supervised daily by researchers. Although dietary lifestyle habits are included in the DianaWeb platform, they are not a specific focus of this study.

Data was collected via an internet platform (http://www.dianaweb.org, accessed on July 2020). The DianaWeb is an open cohort established in September 2016. All Italian BC patients, whatever the disease stage at diagnosis, histological diagnosis, time elapsed since diagnosis, with or without metastasis, local recurrence or second cancers, and with in situ or invasive cancer, are eligible to join the cohort.

In particular, this study uses data collected on both December 2019 and June 2020. In December 2019, the DianaWeb cohort was composed of 1527 breast cancer women. Overall, we selected BC patients (n = 781) that completed the questionnaires in December 2019 and immediately after the first Italian lockdown (June 2020).

The questionnaire areas are accessible only with patient ID and password. The questionnaires considered for this study provided the following data:

(i) general information, such as sociodemographic characteristics (age, education level, marital status, region of residence, and residential density); (ii) anthropometric parameters (body weight, body height, and waist circumference); (iii) information about medical history (lymphedema arms, use of drugs, tumor metastasis, secondary tumor, etc.) and other health issues (from this section we collected information on SARS-CoV-2 positive swab); (iv) results of the last routine blood tests; (v) physical activity level, through the IPAQ-SF, whose reliability and validity are documented [18, 19] : subjects reported the frequency (days/week) and duration (minutes/day) of different types of activity: vigorous (e.g., intense home or gardening activity, performing intense aerobic exercises, and using bike or treadmill); moderate (e.g., moderate home activity, work out in the garden, carrying light loads, and bicycling at a steady pace); and walking activities, as well as the average time spent sitting on a day; and (vi) lifestyle habits on QoL, through the question on one-dimension present in EORTC QLQ-C30 questionnaire [20] : global health-status/quality of life. The global healthstatus/quality of life scale has response options ranging from (1) "very poor" to (7) "excellent".

In May 2020, participants freely provided information through the chat about: (a) different modality used to increase physical activity [technology-based interventions (e.g., apps, Facebook ® , or Instagram); technology-based interventions with a personal trainer (e.g., video-conference, Skype, Zoom video communications including phone conversations, and FaceTime); non-technology interventions (autonomously, without technology support)]; (b) house dwelling floor space (e.g., <50 m 2 , 50-90 m 2 , and >90 m 2 ) and private outdoor spaces (e.g., presence or absence of balcony and/or garden); (c) number of family members; and (d) working activity during quarantine.

Frequency and percentage were provided for categorical data, whereas arithmetic means and standard deviation (SD) were provided for continuous variables. The patients were classified for residence as living in Northern, Central, or Southern Italy. Furthermore, by extending the analysis to residential density, the subjects were classified for living in cities, suburbs, or countryside cities. The education variable was dichotomized into high school or some college (≤13 years) and college graduates or higher (>13 years). The number of family members variable was trichotomized (1, 2, 3, or more members) as well as the dwelling floor space (<50 m 2 , 50-90 m 2 , and >90 m 2 ).

PA levels were calculated from IPAQ-SF, converting questionnaire data in metabolic equivalent minutes per week (MET-min/week): each exercise intensity was associated with the metabolic equivalent of the task (MET): MET = 8 for vigorous, MET = 4 for moderate, MET = 3.3 for walking [21] .

The BMI (kg/m 2 ) was calculated using self-reported height and weight data. The degrees of obesity were established according to the World Health Organization's (WHO) criteria: BMI: 18.5-24.9 kg/m 2 , normal weight; BMI: 25.0-29.9 kg/m 2 , overweight; BMI: 30.0-34.9 kg/m 2 , grade I obesity; BMI: 35.0-39.9 kg/m 2 , grade II obesity; and BMI ≥ 40.0 kg/m 2 , grade III obesity [22] .

The χ 2 test was used to compare qualitative data, whereas ANOVA was used to compare means of normally distributed quantitative data. In the case of statistically significant F-statistics, ANOVA was followed by a Dunnet post-hoc analysis. Pearson's correlation coefficient was calculated to assess the strength and direction of the linear relationships between pairs of variables normally distributed. For non-ordinal variables, the Spearman correlation coefficient was calculated.

A linear multiple regression (LMR, block-wise) method was computed for PA levels (METs for moderate PA, vigorous PA, walking, and total PA) and sitting/lying time as dependent variables. Three blocks of variables were processed. Being the primary purpose of our LMR analysis was to explore the relationship between environment characteristics and PA, the first block consisted in area of residence, residential density, dwelling floor space, and private outdoor spaces. The second block contained socio-demographic variables (age, marital status, number of family members, level of education, and working activity). The third block was made up with health status variables (BMI, waist circumference, lymphedema, health perceptions, QoL, use of psychotropic drugs, and strategies to increase PA).

The independent variables that were relevant and significantly associated with PA from each block (p < 0.05) were included in the logistic regression analysis. Odds ratios values (OR = eβ), showing how the odds change with a one-unit increase in the independent variables, were also reported. All statistical analyses were carried out with SPSS software for Windows (version 20.0; SPSS Inc., Chicago, IL, USA) and p-values <0.05 were considered as statistically significant.

Among the 1527 subjects enrolled in the DianaWeb cohort, 781 (51.5%) completed IPAQ-SF and EORTC-QLQ-C30 questionnaires on both December 2019 and June 2020. Table 1 shows the main sociodemographic characteristics of women enrolled until December 2019 in the DianaWeb study, in particular, the whole cohort and subjects included (Group A) or not in the surveillance study (Group B).

Patients in the two sub-cohorts were similar for age (in both groups the enrolled women were in their 50s), marital status (most of the women were married), level of education, and Italian region of residence. Table 2 presents the distribution of the study population also considering the presence of some barriers or facilitators for PA, as well as referring to the environment (population density, building design, and greenness), family (number of family members), working and clinical characteristics (lymphedema, and SARS-CoV-2 positive swab). Almost half of the sample lived in cities with high population densities and in houses ≥ 90 m 2 (55.1%) with one or more balconies (57.7%). Throughout the period covered by the study, only 9.2% of women worked outside of their homes; most of the women (45.1%) worked remotely.

From March until May 2020, 208 women (26.6%) of the DianaWeb surveillance were tested for SARS-CoV-2 infection and four of them resulted positive.

The anthropometric data after and before quarantine in subjects included in the surveillance study are presented in Table 3 . Mean body weight, waist circumference (WC), and BMI were lower before than during quarantine. When individuals were categorized according to their WC (≤80 cm) or BMI (<18.5, 18.5-24.9 and ≥25.0), we did not observe any significant differences before and during quarantine. In Table 4 , results about QoL and health perception are reported. The analysis showed statistically significant differences between before and during quarantine for both parameters. Stressful events may impact significantly on the initiation of psychotropic drug use. As Table 4 shows, the prevalence of psychotropic drugs use (such as anxiolytics, sedatives, and antidepressants) among participants was, during social isolation, about 16%.

In Table 5 , the results about the PA section are reported. METs of walking, vigorous intensity, and total PA were significantly lower during quarantine, compared with before quarantine. The decreases during home confinement were about 22%, 57%, and 26%, respectively. Additionally, an increase was observed in sedentary behavior: daily sitting/lying time increased significantly from about 5 to 7 h/day, and during lockdown over 54% of women were high sitting (sitting more than 6 h/day). The proportion of women who did vigorous PA or walking decreased significantly (Figure 1a) . The proportion of women who were physically active (a combination of vigorous/moderate PA, and walking) decreased from 98.5% before quarantine to 93.7% during quarantine. The PA level and sitting/lying time, according to sociodemographic characteristics, barriers or facilitators to PA, self-reported PA strategies, anthropometric parameters, QoL, and health perception of the study population during quarantine are presented in Table  S1 . A higher prevalence of physically active women was found among individuals which were 21-40 years old, separated or divorced, worked remotely, lived in Central Italy or in a large house with garden, did not use strategies to do PA, were underweight, did not In addition, the IPAQ score expressed as MET-min/week was used as a general indicator of low active (MET < 600), moderate active (MET ≥ 600), and high active (MET ≥ 3000) people. We found an increase of low active women (<600 MET-min/week) from 9.3% before quarantine to 32.7% during quarantine, with a concurrent and significant reduction of high active women (≥3000 MET-min/week) from 24.7% to 11.4% (Figure 1b) .

Participants most frequently indicated that they did PA without a gym instructor, and only 19.8% did PA with remote personal training ( Figure 2) .

The PA level and sitting/lying time, according to sociodemographic characteristics, barriers or facilitators to PA, self-reported PA strategies, anthropometric parameters, QoL, and health perception of the study population during quarantine are presented in Table S1 . A higher prevalence of physically active women was found among individuals which were 21-40 years old, separated or divorced, worked remotely, lived in Central Italy or in a large house with garden, did not use strategies to do PA, were underweight, did not suffer from lymphedema, and perceived their QoL and health as good.

(a) (b) Figure 1 . (a) Proportion of total and domain-specific physical activity of women before and during COVID-19 home confinement; (b) Proportion of low active (MET < 600), moderate active (MET ≥ 600), and high active (MET ≥ 3000) women before and during COVID-19 home confinement. * Before vs. during quarantine, χ2 test, p < 0.05; Notes: IPAQ score is expressed as MET-min/week; PA = Physical Activity. The PA level and sitting/lying time, according to sociodemographic characteristics, barriers or facilitators to PA, self-reported PA strategies, anthropometric parameters, QoL, and health perception of the study population during quarantine are presented in Table  S1 . A higher prevalence of physically active women was found among individuals which were 21-40 years old, separated or divorced, worked remotely, lived in Central Italy or in a large house with garden, did not use strategies to do PA, were underweight, did not suffer from lymphedema, and perceived their QoL and health as good.

In the multiple regression analysis (Table 6 ), block 1 showed that macroregion of residence and dwelling floor space were significant predictors of moderate PA. Based on our analysis, women living in Northern Italy or owning a house of 90 m 2 or more resulted being facilitated in performing moderate PA. As reported in block 2, age and working activity were also significant predictors of moderate PA. METs from moderate PA were positively associated with age and with time spent at home (women who are retired or working at home increased their moderate PA). Age and number of family members had an inverse association with sitting or lying time. In block 3, BMI was negatively associated with walking, thus indicating that an increase in BMI may be associated with difficulty in walking. QoL had a negative association with sitting or lying time and a positive association with vigorous and total PA, showing that QoL is a key motivator of PA. In the multiple regression analysis (Table 6 ), block 1 showed that macroregion of residence and dwelling floor space were significant predictors of moderate PA. Based on our analysis, women living in Northern Italy or owning a house of 90 m 2 or more resulted being facilitated in performing moderate PA. As reported in block 2, age and working activity were also significant predictors of moderate PA. METs from moderate PA were positively associated with age and with time spent at home (women who are retired or working at home increased their moderate PA). Age and number of family members had an inverse association with sitting or lying time. In block 3, BMI was negatively associated with walking, thus indicating that an increase in BMI may be associated with difficulty in walking. QoL had a negative association with sitting or lying time and a positive association with vigorous and total PA, showing that QoL is a key motivator of PA. After identification of patterns involved in movement behavior changes during the first wave of the COVID-19 pandemic in Italy, we conducted logistic regression analysis (Table 7) including two built environment variables (microregion of residence and dwelling floor space), three socio-demographic variables (age, working activity, and number of fam-ily members), and one health status variable (QoL). Logistic regression models identified in QoL the independent variable that increased PA. The results indicated that women with higher values of QoL were more likely to increase vigorous PA (OR = 1.429; 95% CI 1.092-1.870), moderate PA (OR = 1.415; 95% CI 1.093-1.831), walking (OR = 1.432; 95% CI 1.211-1.693), and total PA (OR = 1.649; 95% CI 1.191-2.284). The logistic analysis showed that there were about 22% lower odds of sedentary (OR = 0.779; 95% CI 0.659-0.920; p = 0.003) for participants with high QoL, and 4% lower odds of sedentary (OR = 0.961; 95% CI 0.943-0.979; p = 0.001) for aged women. 

The DianaWeb study responds to the pressing request of patients diagnosed with BC to know the most advanced point of scientific research on the improvement of prognosis and to have a virtual space to meet, where to obtain evidence-based information about a healthy lifestyle [23] . The DianaWeb page can be effectively used to increase access to accurate information and to monitor participants' lifestyles and health status over time in a very inexpensive way.

It has been observed that COVID-19 quarantine measures could have reduced PA and exercise in different subclasses of population [24] [25] [26] , potentially causing various health side effects. Previous research has demonstrated that compared with individuals without a history of cancer, BC survivors are significantly more likely to develop unhealthy behaviors [27] .

Our survey with 781 BC Italian women revealed that most of the participants reduced their PA level during the quarantine period, in which strict lockdown measures were adopted.

The results showed that MET-min/week of walking, vigorous intensity, and total PA were significantly lower during quarantine compared with before quarantine. In particular, the strongest differences were found in the percentage of high active women (from 24.7% before quarantine to 11.4% during quarantine) and sedentary women (from 9.3% before quarantine to 32.7% during quarantine). Our study also showed that during the pandemic, the daily sitting time significantly increased from about 5 to 7 h/day. Given that previous studies pointed out the detrimental effects of both sedentary behavior and PA on physical and psychological health [28] , BC women of the whole lockdown sample were classified by time sitting/lying (h/day) ( Table 5 ). During lockdown, more than 54% of the surveyed sample spent more than 6 h/day sitting. This phenomenon could be due to a radical change in everyday schedules and habits. However, to mitigate the deleterious effects of inactivity and social isolation, there are many creative ways to be physically active that do not require specialized technology and equipment. In this regard, our data showed that about 60% of the participants did PA autonomously, with non-technological interventions; about 40% had made use of technology-based interventions and only 20% had made use of technology-based interventions with a personal trainer. Although many suggestions and recommendations already exist [29] to PA practice, the COVID-19 pandemic highlighted the importance of understanding common barriers to PA practice and contrasting sedentary lifestyle, creating effective strategies in women with BC diagnosis. About that, this study showed that an emergency context influenced negatively the women's PA behavior with an increase of 25% in inactive time and a decrease of 26% in active time, highlighting the importance of implementing cancer-management strategies.

Our survey agrees with other early reports on lifestyle habits during a pandemic and confirms that the quarantine restrictions were making people more sedentary than ever. In particular, an Italian study [30] highlighted that people who did not practice sports before the quarantine did not take advantage of this period as an opportunity to start and training frequency has increased only among those who already took part in sports. Meyer et al. [31] observed that in a sample of about 3000 American adults, people who were meeting exercise guidelines before the pandemic reported an average 32% reduction in PA level during the emergency and, interestingly, those who were sedentary before were inclined to keep their inactive condition [31] .

The same behavior was observed in previously active BC survivors who reduced their PA, increased weight and sedentary behavior [32] .

Intriguingly, the greatest prevalence of physically active women was among those aged 21 to 40, underweight, who did not suffer from lymphedema, and perceived their QoL and health as good. In multiple regression analyses, QoL was the only significant predictor for vigorous PA. Instead, macroregion of residence, dwelling floor space, age, and working activity were significant predictors of moderate PA. On the other side, age and number of family members had an inverse association with sitting or lying time. Notwithstanding, there were significant negative associations between sitting/lying time and age and QoL. We observed a slight increase in the use of psychotropic drugs (15.7% before vs. 16% during the quarantine) and, in accordance with our data, women with higher QoL values were more likely to increase total PA. These data support the positive association between exercise and improved physical/psychological health that has been well-established and demonstrated in people with cancer. In this regard, clinical evidence of exercise medicine efficacy in cancer management includes diminished symptomatology, enhanced functional capacity, and improved physical/psychological well-being, as well as a potential contribution to BC-specific mortality reduction, and possibly BC non-recurrence [33] [34] [35] [36] [37] .

Efforts should be made to promote physical activity in BC patients. In this context, the implementation of the DianaWeb platform with specific coaching programs to overcome barriers, set realistic goals, and provide personalized advice adapted to BC patients can increase the proportion of women that meet the basic daily recommendation for the level of PA.

The DianaWeb platform itself, centered on an interactive website (http://www. dianaweb.org, accessed on July 2020) designed to supervise the lifestyle habits and health status of BC patients and provide recommendations and suggestions for sustainable lifestyle changes, is considered an important strength. As a community-based participatory research, it is based on the collaborative involvement of all partners in all phases of the research, resulting in high compliance and an incisive knowledge dissemination process.

A limitation is the use of single items for unhealthy behaviors instead of more extensive measurement, e.g., devices to measure PA, which could have given a more precise estimate of the risk, as well as the self-reported questionnaire, which may lead to the actual misreporting of data.

One general limitation attributed to survey research is the oversimplification of social reality and the inconsistency of some collected data such as the percentage of COVID-19 infection within the DianaWeb Italian cohort.

This study showed that COVID-19 emergency increased the unhealthy behaviors in BC patients, indicative of a possible higher risk of worse prognosis. This observation was crucial to support our research group in improving the DianaWeb platform strategy.

In this context, the DianaWeb platform could help women with BC to maintain correct lifestyles based on continuous scientific information easily accessible through the internet, especially in those situations where it is harder to find and obtain conventional forms of professional communication. This tool might support clinical practice also through the development of smartphone apps that are more feasible and faster to use. Fitness applications for smartphones have enjoyed increasing popularity in recent years because of their ease of use. We intend to develop an app to track women's dietary habits, how long they sleep, and how long they perform physical activity. This would be an intriguing way to collect data more objectively, in order to minimize memory bias related to self-compilation of questionnaires. Furthermore, in the future, tumor progression and/or survival data of the DianaWeb study participants will be traced to evaluate whether PA is able to reduce recurrence and mortality for BC. We have established a five-year follow-up to estimate the survival rate in the DianaWeb cohort and to compare it with BC survival rate in the Italian population.

Supplementary Materials: The following are available online at https://www.mdpi.com/article/10 .3390/jpm11050381/s1, Table S1 : PA levels (MET-min/week) and sitting/lying time (h:min/day) by sociodemographic characteristics, region of residence, number of family members, dwelling floor space, private outdoor spaces, residential density, self-reported PA strategies, anthropometric parameters, quality of life, and health perception and use of psychotropic drugs of the study population during quarantine. Data are expressed as the means ± SD and percent of respondents engaged in PA or in sitting/lying. Informed Consent Statement: Informed consent was obtained from all subjects involved in the study.

The data presented in this study are available on request from the corresponding author.

Exercise and Breast Cancer-What is the Evidence for Rehabilitation, Aftercare, and Survival? A Review

The Impact of Exercise on Cancer Mortality, Re-currence, and Treatment-Related Adverse Effects

Leisure time physical activity and cancer risk: Evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies

Cardiorespiratory fitness and cancer in women: A prospective pilot study

How Does Physical Activity Prior to Breast Cancer Diagnosis Effect Rehabilitation Outcomes? Southern California Conferences for Undergraduate Research

Exercise guidelines for cancer survivors: Consensus statement from international multidisciplinary roundtable

Clinical factors associated with adherence to aerobic and resistance physical activity guidelines among cancer prevention patients and survivors

Coronavirus lockdowns have changed the way Earth moves

Effect of physical inactivity on major non-communicable diseases worldwide: An analysis of burden of disease and life expectancy

COVID-19 Clinical Oncology Frequently Asked Questions (FAQs)

Influenza pandemic planning for cancer patients

Coronavirus Disease (COVID-19) Pandemic. 2020

Psychological Health and Physical Activity Levels during the COVID-19 Pandemic: A Systematic Review

A qualitative exploration of barriers and motivators to physical activity participation in women treated for breast cancer

The DianaWeb study to prevent breast cancer recurrences

Community-based participatory research to improve life quality and clinical outcomes of patients with breast cancer (DianaWeb in Umbria pilot study)

Validity of the international physical activity questionnaire short form (IPAQ-SF): A systematic review

International physical activity questionnaire: 12-country reliability and validity

The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology

A simple, easy-to-use spreadsheet for automatic scoring of the International Physical Activity Questionnaire (IPAQ) Short Form. ResearchGate

Un progetto dimostrativo per migliorare la prognosi in donne con carcinoma mammario attraverso gli stili di vita

Coronavirus disease (COVID-19): The need to maintain regular physical activity while taking precautions

Impact of sedentarism due to the COVID-19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological implications and recommendations for physical and nutritional countermeasures

COVID-19 lockdown: Physical activity, sedentary behaviour and sleep in Italian medicine students

Prevalence and correlates of healthy lifestyle behaviors among early cancer survivors

Physical and psychological health among breast cancer survivors: Interactions with sedentary behavior and physical activity

Keeping Patients with Cancer Exercising in the Age of COVID-19

Eating habits and lifestyle changes during COVID-19 lockdown: An Italian survey

Changes in Physical Activity and Sedentary Behavior in Response to COVID-19 and Their Associations with Mental Health in 3052 US Adults

Determinants of Health and Physical Activity Levels Among Breast Cancer Survivors During the COVID-19 Pandemic: A Cross-Sectional Study

Effects of Exercise on Insulin, IGF Axis, Adipocytokines, and Inflammatory Markers in Breast Cancer Survivors: A Systematic Review and Meta-analysis

Overwhelming research and clinical evidence of exercise medicine efficacy in cancer management-translation into practice is the challenge before us

Effects of physical activity on depressive symptoms during breast cancer survivorship: A meta-analysis of randomised control trials

Physical activity in breast cancer survivors: A systematic review and meta-analysis on overall and breast cancer survival

Physical and mental health among cancer survivors: Considerations for long-term care and quality of life

The authors wish to thank the women participating in the DianaWeb study for their effort and time spent to help with this research.

The authors declare no conflict of interest.