key: cord-0943893-unwuv6e3 authors: Choi, Soo-Han title: What are considerations for neonates at risk for COVID-19? date: 2020-07-17 journal: Clin Exp Pediatr DOI: 10.3345/cep.2020.01074 sha: 6da02fa65d3ddd3568808c90c292cdd658557a8c doc_id: 943893 cord_uid: unwuv6e3 nan The World Health Organization (WHO) declared the coro navirus disease 2019 (COVID19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV2) a pandemic on March 11, 2020. As of midJune 2020, over 8 million cases have been confirmed globally. 1) However, data are limited on the transmission, incidence, and effect of SARS CoV2 infection in mothers and newborns. A recent WHO report noted that, of 115 motherinfant pairs from 17 studies in which the mother had confirmed COVID19, 13 infants had COVID19. 2) Of the 20 whose breastmilk was tested for SARSCoV2 RNA particles by reverse transcription polymerase chain reaction (RTPCR), 18 were negative and 2 were positive; one mother's baby was not infected with COVID19 (mixfed), while the other was infected (feeding mo dality not reported). Knight et al. 3) reported the United Kingdom national cohort study of 427 pregnant women admitted to the hospital with confirmed SARSCoV2 infection. The estimated incidence of the hospital admission of pregnant women with confirmed SARSCoV2 infection was 4.9 (95% confidence interval, 4.5-5.0). 4) per 1,000 pregnant women. Four women had a miscarriage at 10-19 weeks' gestation. Of the 262 women who gave birth, 66 (25%) did so preterm: 32 (48%) due to maternal COVID19, 9 (14%) due to fetal compromise, and 12 (18%) due to other obstetric conditions. Three neonates were stillborn and 2 died in the neonatal period; neither of the neonatal deaths was attributed to SARSCoV2. Twelve of the newborns (5%) tested positive for SARSCoV2 RNA: 6 within the first 12 hours of life. Two of 6 infants with earlyonset infection (positive test at <12 hours of age) were born vaginally, while the other 4 were born by caesarean (3 prelabor). In cases of late-onset infection (positive test at ≥12 hours of age), 4 were prelabor caesarean and 2 were vaginal births. Viral analyses were not performed of the umbilical cord blood, placenta, or vaginal secretions. Current evidence is inconclusive about the transplacental viral transmission from mother to newborn. 25) SARSCoV2 transmission to neonates is thought to occur primarily through respiratory droplets during the postnatal period when neonates are exposed to mothers, other caregivers, visitors, or healthcare personnel with COVID19. 4) Since maternal and newborn care units vary in physical configuration, each facility should consider the appropriate space and staffing needs to prevent SARSCoV2 transmission. These considerations include the appropriate isolation of pregnant patients with suspected or confirmed COVID19 and their babies, training for all healthcare personnel on those units to include appropriate infection control practices and personal protective equipment use and handling, and appropriate SARSCoV2 testing of newborn infants. 5) RTPCR testing of upper respiratory tract specimens is ge nerally recommended for all neonates born to women with confirmed or suspected COVID19 regardless of whether the neonate has signs of infection. However, the optimal timing for testing after birth is unknown. Early testing may lead to false positives (due to contamination by SARSCoV2 RNA from maternal fluids) or false negatives (virus not detectable imme diately after exposure following delivery). Newborns should be bathed after birth to remove any virus potentially present on the skin surface. However, SARSCoV2 antibody tests are not recommended for detecting current infection in neonates. 2, 4, 6) Guidance on perinatal care of newborns whose mothers have suspected or confirmed COVID19 were provided by the WHO, the US Centers for Disease Control and Prevention, and the American Academy of Pediatrics (AAP). 2, 4, 6) The 3 organizations suggest that the benefits of breastfeeding in the setting of COVID19 appear to outweigh the potential risks of viral transmission from mother to infant. However, there are some differences among their guidelines in breastfeeding methods as well as maternal and newborn separation practices (Table 1) . 2, 6, 7) The WHO recommends that an infected mother is in close contact with her baby; in infants, the risk of SARSCoV2 infection is low, the infection is typically mild or asymptomatic, and the consequences of not breastfeeding or of separating mother and child can be significant. 2) The AAP focuses on mi nimizing neonatal infection by suggesting that the risks and benefits of temporary maternalnewborn separation be discussed with the mother by the healthcare team and decisions be made in accordance with the mother's wishes. 6) These guidelines are being updated as more clinical information and scientific evidence become available. The city of Daegu had the first large outbreak of COVID19 outside of China in late February to March 2020. Predominance by the 20s age group and female sex may have caused by the outbreak related to a religious group in Daegu. 8) Lee et al. 9) reported the case of the first newborn baby born to a mother with confirmed COVID19 in Daegu, South Korea. At that time, the guidance on perinatal care started with extremely little evidence. 10) The situation of COVID19 in Korea is still evolving; therefore, it is imperative to properly update the guidelines for COVID19 in a timely manner. No potential conflicts of interest relevant to this article are reported. See the article "Management of the first newborn delivered by a mother with COVID19 in South Korea" via https://doi. org/10.3345/cep.2020.00850. If the neonate tests positive for SARS-CoV-2, separation is not necessary. b) Mothers may express breast milk after performing appropriate breast and hand hygiene and the infant may be fed by other uninfected caregivers. c) There is no indication for routine testing of asymptomatic babies, but it can be performed if resources permit. World Health Organization. Coronavirus disease (COVID19) pandemic World Health Organization Clinical management of COVID19: Interim guidance 27 World Health Organization Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARSCoV2 infection in UK: national population based cohort study Evaluation and management considerations for neonates at risk for COVID19 Centers for Disease Control and Prevention Considerations for inpatient obstetric healthcare settings Centers for Disease Control and Prevention FAQs: management of infants born to mothers with suspected or confirmed COVID19 American Academy of Pediatrics; c2020 Frequently asked questions within neonatal services. A BAPM supplement to RCPCH guidance Korean Society for Antimicrobial Therapy, Korean Society for Healthcareassociated Infection Control and Prevention Management of the first newborn given birth by a mother with COVID19 in South Korea Guidelines for coronavirus disease 2019 response in children and adolescents