key: cord-0943797-5n84thb6 authors: Taghizadieh, Ali; Mikaeili, Haleh; Ahmadi, Majid; Valizadeh, Hamed title: Acute kidney injury in pregnant women following SARS-CoV-2 infection: A case report from Iran date: 2020-05-13 journal: Respir Med Case Rep DOI: 10.1016/j.rmcr.2020.101090 sha: 6116dc8225e3f0670bb656a7baaf290067120447 doc_id: 943797 cord_uid: 5n84thb6 We reported a 33-year-old female case with novel coronavirus disease 2019 (COVID-19) accompanied by Acute tubular necrosis (ATN). She had a gestational age of 34 weeks. The patient referred to treatment clinic for COVID-19 in Imam Reza hospital of Tabriz (Iran) after having flu-like symptoms. In radiologic assessment, ground glass opacity (GGO) with consolidation was found in upper right lobe. Lopinavir/ritonavir (200mg/50mg) two tablet tow times, Ribavirin 200mg every six hours, and Oseltamivir 75mg tow times were given for the treatment of COVID-19. The medications used for treatment of pneumonia were Meropenem, Ciprofloxacin, Vancomycin. All doses of medications were administrated by adjusted dose assuming the patient is anephric. Also, a few supplements were also given after ATN development including daily Rocaltrol and Nephrovit (as a multivitamin appropriate for patients with renal failure), Folic acid and Calcium carbonate. The patient is still under ventilator with a Fraction of inspired oxygen (FiO(2)) of 60% and Positive end-expiratory pressure (PEEP) of eight. SpO(2) is 94% but the patient's ATN problem has been resolved. We started weaning from mechanical ventilator. The patient is conscious with full awareness to time, person and place. The maternal well-being is achieved and her neonate was discharged. Coronaviruses are a large family of viruses that were first discovered in 1960. They cause common cold in humans and animals, and are characterized by their crown-like thrones on the wall surfaces of viruses. Such sever diseases emerged in the last 20 years responsible for severe symptoms including SARS-CoV-2 which is the cause of the ongoing pandemic [1, 2] . Symptoms of coronavirus appear in the lungs with pneumonia, which is usually associated with mild cold in most people. But there are some types of the virus that are associated with more severe symptoms such as Severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and SARS-CoV-2 causing COVID-19 [3] . Finally, on December 2019, for the first time in Wuhan city of China, a new type of coronavirus was identified with a human epidemic after people contracted pneumonia and vaccines and treatments were ineffective, so that named COVID-19 [4] . Depending on the type of coronavirus, symptoms can range from symptoms of common cold to fever, cough, shortness of breath and acute respiratory problems [5, 6] . The patient with COVID-19 may also have a few days of apparently unexplained coughs that affect not only the respiratory tract but also other vital organs of the body such as the kidney and liver. Acute gastrointestinal problems such as diarrhea, acute respiratory failure, coagulation disorders and acute renal failure have also been reported that may require hemodialysis [7] [8] [9] . We would like to report a case of pregnant woman with COVID-19 who developed acute tubular necrosis (ATN). A 33-year-old female without comorbidity who had symptoms of the cold a week ago referred to treatment clinic for COVID-19 in Imam Reza hospital of Tabriz, Iran. After Polymerase chain reaction (PCR) test through the nasopharyngeal swab and radiologic examination, she was hospitalized. The symptoms worsened and she was intubated on the second day. The patient was also pregnant with a gestational age of 34 weeks. The patient did not receive nephrotoxic drugs such as antibiotics before uremia, and when her BUN and Cr increased, the patient's urine became muddy brown and the volume of urine decreased, and we called it Acute kidney injury (AKI). In our urine sedimentation, there were a lot of granular casts along with cellular debris, which was interpreted as ATN. Due to the presence of urinary sedimentation and the presence of granuloma casts in the urine and muddy brown nature of urine, the diagnosis of ATN was more important than urinary toxicity. In spite of using Furosemide, urine output was 600 cc in 24 hours. After hemoperfusion, urine output reached above 2 liters in 24 hours and we entered the polyuria phase . However, Vancomycin was eliminated and Linzolid started for the patient because it is not nephrotoxic. Also, a few supplements were also prescribed after developing ATN including daily Rocaltrol and Nephrovit (as a multivitamin appropriate for patients with renal failure), Folic acid and Calcium carbonate. Vitamin C 250 mg is administrated by gavage. Hemoglobin and white blood cell at admission time were 11 mg/dl and 2400 per microliter, respectively; so that pancytopenia was diagnosed and suspected of having lupus erythematous. Therefore, rheumatology consultation was asked, all of lupus diagnostic criteria were negative but received Intravenous immunoglobulin (IVIG) 5 gr daily for 5 consecutive days after consultation with hematologist. The patient did not have peripheral schistocyte in the blood, we did not make diagnoses such as microangiopathy (thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: TTP-HUS) and only Collagen vascular disease (CVO) due to anemia and vascular thrombocytopenia was evaluated. The patient's anemia and thrombocytopenia improved after hemoperfusion and the patient had an increase in hemoglobin and platelets. The patient's electrolytes were regularly monitored. As mentioned, due to the lack of schistocyte in the peripheral blood, microangiopathy was ruled out. Lupus tests including C3, CH50, Cu and Anti-dsDNA were negative. Primary LDH was 1360 that decreased to 380 after hemoperfusion. Serum glutamic oxaloacetic transaminase (SGOT) and Serum glutamic pyruvic transaminase (SGPT) were 78 and 46 units per liter of blood serum, respectively. The patient's PCR test was positive, so a CT scan was taken and showed ground glass opacity (GGO) with consolidation in upper right lobe indicating lung involvement. Preoperative CT is presented when the patient was not intubated yet ( Figure 1 ). After admission, creatinine levels gradually increased up to 6.8 mg/dl accompanied by respiratory and metabolic acidosis in the arterial blood gas (ABG). The patient's respiratory rate increased to 36 breaths /minute and the patient was intubated. She underwent caesarean section after consultation with a gynecologist. he patient had to undergo dialysis 12 hours before caesarean section. The baby was negative for COVID-19 and was in good health. Due to the low platelet count, the patient entered the operating room with 10 platelet injections. Before surgery Hb was 7.25 mg/dl (Blood Pressure=100/66 mmHg, prothrombin time (PT) =16s, partial thromboplastin time (PTT) = 36s, Pco2=45 mmHg, Hco3=18 mEq/L) After surgery, hemoglobin had reached 7.8 mg/dl, which inevitably received a unit washed packed cell, and hemoglobin is now 9.5 mg/dl. White blood cell (WBC) increased to 7,400 per microliter. On the sixth day of hospitalization, diuresis was established, and the patient's creatinine declined sharply. The patient's creatinine had reached 3 mg/dl and conservative treatment was launched. The patient is still hospitalized due to COVID-19 and is in the recovery phase with fluid control and does not receive medication for her ATN. The patient is still intubated with a fraction of inspired oxygen (FiO 2 ) of 60% and Positive end-expiratory pressure (PEEP) of eight. SpO 2 is 94% but the patient's ATN has been resolved. We started weaning the mechanical ventilation. The patient is conscious with full awareness to time, person and place. The maternal well-being is achieved and her neonate was discharged. Postoperative Chest-x ray is presented ( Figure 2 ). As shown, pneumonia is clear in the figure that's why the patient is giving Ciprofloxacin, Vancomycin and Meropenem now. We know that COVID-19 involve multiple organs, in such a way that renal failure was reported in two studies [10] [11] [12] [13] [14] . Due to low studies in favor of kidney disease and COVID-19, it is hard to make decision in this regard, but what we've seen is the fact that ATN is treated by supportive measure [15] . Maybe routine measures are sufficient, so that kidney replacement therapy is another choice for the treatment of these patients if necessary. Indeed supportive measure can be efficient. So far, no effective antiviral drug was found to treat COVID-19 patients; therefore new drug cannot be named and prescribed without approved results [16] . Various viruses can cause ATN such as Lassa and others [17] , and in our case report, SARS-CoV-2 caused ATN. In pregnant women, the manifestation of chest graph does not differ so that the most common finding in corona-positive patients with pneumonia was GGO [18, 19] . The reported case had GGO in upper right lobe. The clinical manifestation of pregnant women with COVID-19 is the same other non-pregnant women [20] [21] [22] . Given these finding, we did the same and treat like other people. But regarding CT scan, we took it conservatively due to her pregnancy and getting low radiation. Taking chest X-ray was not limited and when it was necessary, we checked it. After delivery and checking the COVID-19 status in the neonate, we found that neonate are resistant to corona virus than of adults because PCR test was negative. Previously, two neonatal cases of COVID-19 have been reported without severe symptoms [23] . The risk of vertical transmission of novel corona virus is low but never reach zero and prevention measure in any levels should be adapted [23, 24] . The exact pathology of AKI in patients with COVID-19 was not known but the role of angiotensin-converting enzyme 2 (ACE2) was reported [25] . We know that AKI is happen infrequent in pregnant women. To prevent the development of AKI in patients with mild renal insufficiency such as increase in creatinine potentially can reduce the likelihood of AKI development. In this regard, we made a decision that the patient should undergo hemodialysis to prevent the development of AKI and fortunately we were successful [26] . In a study by Wang et al., SARS-CoV-2 RNA was found in 53 urine sediments through real-time reverse transcription-polymerase chain reaction [27] . These case report and other related study indicate the effect of COVID-19 on the Identification of a new human coronavirus Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV Naming the coronavirus disease (COVID-19) and the virus that causes it Coronavirus humains (HCoV) Human coronaviruses Presumed asymptomatic carrier transmission of COVID-19 Kidney disease is associated with in-hospital death of patients with COVID-19 Coronavirus-nephropathy renal involvement in COVID-19 Acute respiratory distress syndrome in COVId-19 disease Drug therapy in hospitalized patients with very severe symptoms following COVID-19 Overview of management of acute renal failure and its evaluation; a case analysis What to do if you are sick with 2019 Novel Coronavirus (2019-nCoV) COVID-19 is a complex disease with wide spectrum of clinical patterns and an emerging problem for nephrologist Acute kidney injury in COVID19 What are the risks of COVID-19 infection in pregnant women? Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia Clinical Display, Diagnostics and Genetic Implication of Novel Coronavirus (COVID-19) National Health Commission of the People's Republic of China Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records COVID-19 interactions with angiotensin-converting enzyme 2 (ACE2)and the kinin system; looking at a potential treatment Acute kidney injury during pregnancy Coronavirus Disease 19 Infection Does Not Result in Acute Kidney Injury: An Analysis of 116 Hospitalized Patients from Wuhan, China Figure 2: Postoperative Chest-x ray of intubated patients with COVID-19 None of the authors has any potential financial conflict of interest related to this manuscript.