key: cord-0943398-x3fdflv0
authors: Chang, Min Cheol; Kim, Tae Uk; Park, Donghwi
title: National early warning score on admission as risk factor for invasive mechanical ventilation in COVID-19 patients: A STROBE-compliant study
date: 2021-05-14
journal: Medicine (Baltimore)
DOI: 10.1097/md.0000000000025917
sha: b70e1f06de68cc18cb190fb1ddcfeb026eac2f1c
doc_id: 943398
cord_uid: x3fdflv0

The coronavirus disease (COVID-19) has become a global pandemic. Invasive mechanical ventilation is recommended for the management of patients with COVID-19 who have severe respiratory symptoms. However, various complications can develop after its use. The efficient and appropriate management of patients requires the identification of factors associated with an aggravation of COVID-19 respiratory symptoms to a degree where invasive mechanical ventilation becomes necessary, thereby enabling clinicians to prevent such ventilation. This retrospective study included 138 inpatients with COVID-19 at a tertiary hospital. We evaluated the differences in the demographic and clinical data between 27 patients who required invasive mechanical ventilation and 111 patients who did not. Multivariate logistic regression analysis indicated that the duration of fever, national early warning score (NEWS), and lactate dehydrogenase (LDH) levels on admission were significantly associated with invasive mechanical ventilation in this cohort. The optimal cut-off values were: fever duration ≥1 day (sensitivity 100.0%, specificity 54.95%), NEWS ≥7 (sensitivity 72.73%, specificity 92.52%), and LDH >810 mg/dL (sensitivity 56.0%, specificity 90.29%). These findings can assist in the early identification of patients who will require invasive mechanical ventilation. Further studies in larger patient populations are recommended to validate our findings.

Following the diagnosis of the first case of coronavirus disease in December 2019, the infection has rapidly spread worldwide, with the World Health Organization classifying the outbreak as a pandemic on March 11, 2020. [1] [2] [3] Although the respiratory symptoms are mild in over 80% of patients with COVID-19, they are severe in 10% to 20%. [4] Approximately 2% to 5% of patients die because of massive alveolar damage and progressive respiratory failure. [5] The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a positive-sense, long (30,000 bp), single-stranded RNA coronavirus that belongs to the family Coronaviridae and genus Betacoronavirus and very similar to SARS-CoV. [3] In patients with severe disease, large amounts of fluids and mucus accumulate in the lung, blocking the oxygenation of lung tissues. [6, 7] Low oxygen levels in the blood can lead to the death of patients. Therefore, invasive mechanical ventilation is used in these patients. Invasive mechanical ventilation is a life-saving technology that pushes air and oxygen into the lungs of patients using a machine. [8] It helps to stabilize patients with hypoxemic respiratory failure by decreasing the inspiratory work of breathing and enabling gas exchange while the lung infection is treated and proper lung function is restored. [8] However, its use in COVID-19 patients has led to mucosal ulceration, pneumonia, lung injury, respiratory muscle wasting, swallowing dysfunction, and neuropsychiatric complications. [9] Furthermore, the required intubation or tracheostomy may result Editor: Babak Abdinia.

This study was supported by a National Research Foundation of Korea Grant funded by the Korean government (Grant no. NRF-2021R1A2C1013073).

Financial disclosure: No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.

in adverse effects, such as laryngeal or tracheal injury, laryngotracheal stenosis, or tracheomalacia. [10] [11] [12] Consequently, it is critical to identify factors associated with an aggravation of COVID-19 respiratory disease to a degree where invasive mechanical ventilation is required so that these patients can be efficiently and appropriately managed, thereby preventing the use of invasive mechanical ventilators.

In the current study, we retrospectively reviewed the files of COVID-19 patients who had been admitted to our university hospital and compared various demographic and clinical factors between patients who required invasive mechanical ventilation and those who did not.

This retrospective study reviewed the medical records of adult inpatients (aged ≥19 years) at the Yeungnam University Hospital in Daegu, Republic of Korea. All patients diagnosed with COVID-19 according to the World Health Organization interim guidance were eligible for participation. The study period was from February 11, 2020 (i.e., when the first patients were admitted) and June 15, 2020.

Based on these criteria, the data of a total of 138 adult patients with COVID-19 were extracted and analyzed in this study.

The protocol of this study was approved by the Institutional Review Board of Yeungnam University Hospital. The requirement for informed consent was waived by the Ethics Commission because of the nature of this study as a retrospective file review. All methods were performed in accordance with relevant guidelines and regulations for retrospective file reviews.

Using a standardized data collection form, demographic, epidemiological, and clinical data were extracted from the electronic medical records of the patients by 2 physicians.

After fasting for at least 8 hours, blood samples were drawn from the ante-cubital vein into vacuum tubes and analyzed at the Yeungnam University Hospital's certified laboratories. [13] We recorded the following variables: and Korean Ministry of Food and Drug Safety. [14] For SARS-CoV-2 detection using RT-PCR, the following steps are required: sample collection, sample preparation, nucleic acid extraction, reverse transcription, and PCR using real-time fluorescence signal detection. The RT-PCR test for COVID-19 requires 2 separate assays over a 24-hour period using nasopharyngeal and oropharyngeal swabs. [14] Therefore, in this study, upper respiratory specimens (including both nasopharyngeal and oropharyngeal swabs) were used. All COVID-19 diagnoses using the RT-PCR kits in this study were made by the Department of Diagnostic Examination Medicine at Yeungnam University Hospital.

Based on previous research on the risk factors for COVID-19 and the classification system announced by the KCDC, the presence of chronic underlying diseases, such as diabetes, chronic kidney disease (CKD), carcinoma, cardiovascular disease, chronic lung disease, dyslipidemia, and hypertension, was recorded. [15] Chronic lung disease was defined as asthma, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, interstitial lung disease, or bronchiectasis. [16, 17] Additionally, any neurological disorders, such as Alzheimer disease, were also recorded. [15] We further noted the details of patients' symptoms, such as fever (>37.7°C), duration of fever, chills, dyspnea, nonproductive cough, productive cough, sore throat, myalgia, rhinorrhea, diarrhea, and headache at any point during the disease.

We investigated initial lung involvement using chest radiography. We recorded whether the patient's lungs were unilaterally or bilaterally affected. [18] A radiologist checked and confirmed the radiological findings.

National early warning score. We recorded the national early warning score (NEWS) of patients on admission. [19] [20] [21] The NEWS was originally designed to identify deteriorating patients in hospital wards, specifically those at an increased risk of intensive care unit (ICU) admission, cardiac arrest, or death within 24 hours. [19] [20] [21] Recently, the NEWS has been increasingly used to predict the prognosis of patients with COVID- 19 . The NEWS consists of 6 parameters and is designed to improve the early detection of and response to clinical deterioration. [19] [20] [21] The score ranges for each parameter from 0 to 3, and the individual scores for each parameter are combined to produce an overall score. An additional 2 points are added if the patient is receiving oxygen therapy. The overall score ranges from 0 to 20: the higher the score, the greater the clinical risk. [19] [20] [21] 

Continuous data were presented as the mean ± standard deviation and range. Categorical data were presented as the number and percentage.

The independent t test and chi-square test were used to identify potential risk factors for invasive mechanical ventilation by comparing the patients who required it with those who did not. Any factors showing a significant association were then further investigated using multivariate logistic regression analysis. We performed a receiver operating characteristic (ROC) analysis to evaluate the accuracy of predictive factors for invasive mechanical ventilation. We used the maximum Youden index to determine the cut-off values for parameters shown to be significant.

All statistical analyses were conducted using IBM SPSS Statistics for Windows, version 22 .0 (IBM Corp., Armonk, NY). A P-value <.05 was considered to be statistically significant.

The mean patient age was 60 The clinical characteristics of all patients and differentiated between those who required ventilation, and those who did not, is shown in Table 1 .

All patients were treated with either hydroxychloroquine sulfate 400 mg (Oxiklorine, Myungmoon Pharm. Co., Ltd., Seoul, South Table 1 Clinical characteristics of hospitalized patients (n = 138) with COVID-19.

All 

In patients receiving invasive mechanical ventilation, the prevalence of fever, dyspnea, headache, abnormal findings on chest radiographs, bilateral involvement of the lungs, diabetes, hypertension, neurologic disease, and CKD was statistically significantly higher than that in patients who were not ventilated (P < .05; Table 1 ). In addition, the systolic blood pressure, white blood cell and platelet count, percentage of neutrophils, percentage of lymphocytes, total bilirubin, aspartate transaminase, glucose, blood urea nitrogen, creatinine, procalcitonin, Creactive protein, lactate dehydrogenase (LDH), duration of fever, oxygen saturation, and NEWS on admission were significantly different between COVID-19 patients with and without invasive mechanical ventilation (P < .05; Table 1 ). The multivariate logistic regression analysis indicated that only the duration of fever, NEWS, and LDH level on admission were significantly associated with invasive mechanical ventilation. In these patients, the area under the ROC (AUROC) for the duration of fever in predicting invasive mechanical ventilation was 0.825 (95% confidence interval [CI], 0.751-0.884; P < .0001). The optimal cut-off value was ≥1 day (sensitivity 100.0%, specificity 54.95%). The AUROC for the NEWS in predicting invasive mechanical ventilation was 0.889 (95% CI, 0.821-0.937; P < .0001), and the optimal cut-off score was ≥7 (sensitivity 72.73%, specificity 92.52%). The AUROC for the LDH level in predicting invasive mechanical ventilation was 0.799 (95% CI, 0.720-0.865; P < .0001), and the optimal cut-off value was >810 mg/dL (sensitivity: 56.0%, specificity: 90.29%) ( Table 2 and Fig. 1 ).

In this retrospective study, we investigated the risk factors for requiring invasive mechanical ventilation in patients with COVID-19 who were admitted to our university hospital. We found that fever for >1 day, a NEWS ≥7, and an LDH level >810 mg/dL on admission were risk factors that aggravated the respiratory symptoms in these patients to the degree that invasive mechanical ventilation was necessary. The accuracy of these risk factors in indicating the later need for invasive mechanical ventilation was good (AUROC: fever = 0.825, NEWS = 0.889, LDH level = 0.799).

Fever is a response to pyrogenic cytokines such as tumor necrosis factor, interleukin (IL)-1, IL-6, and interferons being released into the bloodstream. [22] These cytokines activate alveolar macrophages and recruit neutrophils to the lungs, which in turn activate leukotrienes, oxidants, platelet-activating factors, and proteases. [23] These substances damage the capillary and alveolar epithelium, thereby disrupting the barrier between the capillaries and the air spaces. [24] This can cause edema with fluid and cellular debris filling the air spaces and lung interstitium, resulting in airspace collapse, ventilation-perfusion mismatch, and disruption of the surfactant microarchitecture. [24] Fever for >1 day can lead to a larger release of pyogenic cytokines, which can damage lung tissue to the degree that patients require invasive mechanical ventilation.

NEWS is a tool developed by the Royal College of Physicians to improve the early detection of clinical deterioration in adult patients with acute illnesses. [21] It determines the degree of acute illness in a patient and prompts critical care intervention. It is widely used in clinical practice, but thus far, only a few studies have evaluated its usefulness during the COVID-19 pandemic. [25, 26] In our study, a NEWS ≥7 on admission indicated a high risk of invasive mechanical ventilation. Our results are similar to those of a previous study in 66 COVID-19 patients (13 patients died during hospitalization, and 53 were discharged alive) who were hospitalized in a general public hospital in Oslo, Norway. [27] The authors defined severe disease as a composite measure of death and ICU treatment during hospitalization. They reported that a NEWS2 ≥6 on admission predicted progression to the severe disease with a sensitivity of 80% and a specificity of 84%.

Our study also showed that patients with an elevated LDH level >810 mg/dL on admission were more likely to require invasive mechanical ventilation. Increased serum LDH levels are an indicator of tissue damage and inflammation. [28] Thus, they may indicate severe damage or inflammation of the lung in patients with COVID- 19 . This finding concurs with the results of previous studies. Zheng et al [29] performed a meta-analysis of 13 studies on the risk factors of critical or mortal COVID-19 cases. Furthermore, Guan et al, [30] in their analysis of >1000 patients in China reported that an elevation of LDH is one of the predictive factors of critical or mortal COVID- 19. To date, several studies have evaluated risk factors of severe COVID-19 and mortality. [30] [31] [32] [33] [34] [35] [36] These indicate that male sex, age >65 years, active smoking, comorbidities (hypertension, diabetes, and cardiovascular disease), dyspnea, and elevated HLD, white blood count, aspartate transaminase, creatinine, and Ddimer levels are risk factors for the development of a critical condition. However, thus far, risk factors for the use of invasive mechanical ventilation in COVID-19 have not been evaluated.

Our results need to be interpreted within the limitations of this study. Our study is characterized by its relatively small number of patients, resulting in a selection bias. Table 2 Risk factors associated with the need for invasive mechanical ventilation in hospitalized adult patients (n = 138) with COVID-19. Chang et al. Medicine (2021) 100: 19 Medicine In conclusion, we found that fever for >1 day, a NEWS ≥7, and an LDH level >810 mg/dL on admission were risk factors of invasive mechanical ventilation in patients with COVID-19. Therefore, special attention must be paid to COVID-19 patients with these risk factors. We recommend timely and personalized treatment in these patients to enhance efficacy and reduce the risk of aggravation of their respiratory symptoms. We believe our study can help to identify patients at risk of requiring invasive mechanical ventilation early. Further studies with larger cohorts are recommended. 

Lessons from South Korea regarding the early stage of the COVID-19 outbreak

Strategies for the prevention of the intrahospital transmission of COVID-19: a Retrospective Cohort Study

Quinolines-based SARS-CoV-2 3CLpro and RdRp inhibitors and Spike-RBD-ACE2 inhibitor for drug-repurposing against COVID-19: an in silico analysis

Risk factors for disease progression in COVID-19 patients

Evaluation, and Treatment of Coronavirus (COVID-19). StatPearls: Treasure

Airway mucus function and dysfunction

The acute respiratory distress syndrome: mechanisms and perspective therapeutic approaches

Ventilator Management. 2020;StatPearls

Mechanical ventilation: invasive versus noninvasive

Current status of indications, timing, management, complications, and outcomes of tracheostomy in traumatic brain injury patients

Application of different ventilator modes in patients with amyotrophic lateral sclerosis according to certain clinical situations: a Case Report

Different characteristics of ventilator application between tracheostomy-and noninvasive positive pressure ventilation patients with amyotrophic lateral sclerosis

Fasting plasma glucose level independently predicts the mortality of patients with coronavirus disease 2019 infection: a multicenter, retrospective cohort study

Interpreting the COVID-19 test results: a guide for physiatrists

Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study

Managing your chronic lung disease during the COVID-19 pandemic

Race, ethnicity, socioeconomic status, and chronic lung disease in the U

Chest computed tomography findings in asymptomatic patients with COVID-19

Early warning system scores for clinical deterioration in hospitalized patients: a systematic review

Use of National Early Warning Score for observation for increased risk for clinical deterioration during post-ICU care at a surgical ward

Using the National Early Warning Score (NEWS) outside acute hospital settings: a qualitative study of staff experiences in the West of England

Circulating cytokines as mediators of fever

Roles of the neutrophil and other mediators in adult respiratory distress syndrome

Consequences of hyperoxia and the toxicity of oxygen in the lung

Prognostic accuracy of the SIRS, qSOFA, and NEWS for early detection of clinical deterioration in SARS-CoV-2 infected patients

National early warning score (NEWS) and the new alternative SpO2 scale during rapid response team reviews: a prospective observational study

Figure 1. The cut-off values of the risk factors for invasive mechanical ventilation identified in this cohort of patients (n = 138) with COVID-19. (A) The area under the receiver operating characteristic curve (AUROC) of the duration of fever for predicting invasive mechanical ventilation was 0

The optimal cut-off value assessed using the maximum Youden index (J) was ≥1 day (sensitivity 100.0%, specificity 54.95%). (B) The AUROC of the national early warning score on admission for predicting invasive mechanical ventilation was 0

0001), and the optimal cut-off value was ≥7 points (sensitivity 72.73%, specificity 92.52%). (C) The AUROC of the LDH levels on admission for predicting invasive mechanical ventilation was 0

0001), and the optimal cut-off value was >810 mg/dL (sensitivity 56.0%, specificity 90.29%). LDH = lactate dehydrogenase

Medicine (2021) 100:19 www.md-journal

National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 -a prospective cohort study

Clinical and diagnostic significance of lactate dehydrogenase and its isoenzymes in animals

Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis

Clinical characteristics of coronavirus disease 2019 in China

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Risk factors for disease progression in hospitalized patients with COVID-19: a retrospective cohort study

Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China

Online ahead of print

Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan

Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

The authors have no conflicts of interest to disclose.All data generated or analyzed during this study are included in this published article [and its supplementary information files].