key: cord-0943257-q662dmqb
authors: Hong, Jun Ki; Shin, Sun Hye; Yoo, Kwang Ho; Li, Kapsok; Seo, Seong Jun
title: Symmetric drug–related intertriginous and flexural exanthema–like eruption related to coronavirus disease 2019 vaccine
date: 2022-03-20
journal: Contact Dermatitis
DOI: 10.1111/cod.14092
sha: 7e32cea4b41bb6ea2bd3c626b4d9395f03fdd6f2
doc_id: 943257
cord_uid: q662dmqb

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The blood test results were normal. Findings of direct microscopy with 10% potassium hydroxide (KOH) and wound culture were negative. The patient refused to undergo a skin biopsy. Based on these findings and the patient's history, we considered symmetric drugrelated intertriginous and flexural exanthema (SDRIFE)-like eruption.

Methylprednisolone 30 mg/day was administered for 1 week, and the dose was tapered to 15 mg/day for another week with topical corticosteroid cream. After 2 weeks, his condition resolved.

SDRIFE, a type IV hypersensitivity drug-related skin eruption that affects the skin folds, is commonly caused by β-lactam antibiotics, 5-aminosalicylic acid, iodine radiocontrast, and monoclonal antibodies. 

Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Contact Dermatitis

Symmetrical drug-related intertriginous and flexural exanthema like eruption associated with COVID-19 vaccination [published online ahead of print

Systemic drug-related intertriginous and flexural exanthema induced by the Pfizer-BioNTech COVID-19 vaccine: a report of 2 cases

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Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registrybased study of 414 cases

Symmetric drug-related intertriginous and flexural exanthema-like eruption related to coronavirus disease 2019 vaccine