key: cord-0942963-ky0lgx4o authors: Adiguzel, Yekbun title: Molecular mimicry between SARS-CoV-2 and human proteins date: 2021-02-18 journal: Autoimmun Rev DOI: 10.1016/j.autrev.2021.102791 sha: 31bc75880ab98d246ebc22185ce9ea0da18ae8ba doc_id: 942963 cord_uid: ky0lgx4o nan Human proteins that align with SARS-CoV-2 peptide CFLGYFCTCYFGLFC with more than 7 residue matches. They are predicted to contain epitopes with at least 5 residue matches to the respective epitope regions in the query. Alignments are displayed as they are presented in the original file, but matching residues are written bold. Those residues in the predicted epitope parts are still bold if present. Yet they are further underlined if present in both query and subject epitopes. Gaps in the alignments are not shown in the epitopes. Numbers in front of the epitope pairs indicate the HLA allele and the predictor, as specified at the title row. However, only the epitopes predicted by NetMHCcons are displayed when significant predictions that are indicated at both 1 and 2, or 3 and 4, are present. MOL37243.1 Phospholipid phosphatase-related protein type 2 LGYFCT---CYFGLF 1 GYFCTCYFGLF XP_024307423.1 CFLGYFCTCYFGL 1 CFLGYFCTCYFGLF 3 FLGYFCTCYFGL CYLGYW---YFDL 2 CYLGYWYFDL YLGYWYFDL MCC33910.1 LGY-CSSTSCYFGFF 2 GYCSSTSCYFGFF LGYFCTCYFGL 2 GYFCTCYFGL LGYLCT--FXL GYLCTFXL 4OO9_A and 6FFH_A LGYFCTCYFGL LGTF-TYYYGL LGTFTYYY ADM43945 Relationships of those proteins with autoimmunity can be mentioned further. E.g., plasminogen activation system has important functions, and its deregulation is connected to pathological conditions like cancer, bacterial infection, fibrosis, neurogenerative diseases, muscular dystrophy, and rheumatoid arthritis [20] . Besides, elevated plasmin(ogen) was suggested to be a risk factor for COVID-19 susceptibility [21] . Plasminogen receptor KT is a membrane protein, expression of which increases on the surface upon inflammatory stimuli, like in case of several other plasminogen receptors [20] . Its contribution to the inflammatory diseases, together with the cell-surface associated plasmin activity, is yet to be elucidated, particularly in conditions where macrophages play a preeminent role in the pathogenesis, for being highly expressed at the proinflammatory macrophages [20] . Examples of such diseases are microglial cells and neuroinflammatory disease, Kupfer cells and hepatotoxic injury, Mi-type adipose tissue macrophage and obesity [20] . Another one, adenosine receptor A2b was suggested to play a role in inflammation [22] , and immunoglobulin heavy chain variable 5-51, was reported to be among the modulated-genes in the patients with systemic sclerosis, which is characterized by immune system alterations, for being an autoimmune connective tissue disease [23] . Immunoglobulin heavy chain variable 5-51 is also among the 115 genes that are co-occurring with the disease autoimmune hemolytic anemia, in the abstracts of J o u r n a l P r e -p r o o f biomedical publications from the DISEASES Text-mining Gene-Disease Association Evidence Scores dataset [24] . Last, antibodies against metabotropic glutamate receptor 5 is among the antibodies that are possibly associated with autoimmune encephalitis [25] [26] . Inhibitors of metabotropic glutamate 5 receptor were offered as a therapeutic strategy to fight against COVID-19 [27] , and it was suggested that the therapeutic effect would be acting through interfering with the viral hijacking of the host protein synthesis [27] . It is worth to mention in the end that, other than one immunoglobulin heavy chain junction region (sequence ID MCG41834.1), the highest statistical significance in the alignments are observed for the peptides of slit homolog 2 protein and the solute carrier family proteins, among the proteins that are mentioned above. on behalf of the HLH Across Specialty Collaboration, UK. COVID-19: consider cytokine storm syndromes and immunosuppression COVID-19) time musings: Our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning Is COVID-19 a proteiform disease inducing also molecular mimicry phenomena? Guillain Barre syndrome associated with COVID-19 infection: A case report COVID-19 and molecular mimicry: The Columbus' egg? 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