key: cord-0941052-0wu2movm
authors: Roche, D.; O’Connor, C.; Murphy, M.
title: Ivermectin in dermatology: why it ‘mite’ be useless against COVID‐19
date: 2021-06-26
journal: Clin Exp Dermatol
DOI: 10.1111/ced.14704
sha: 16eba4f65fd6f222d6edb2ff64a6f34c040a5bbb
doc_id: 941052
cord_uid: 0wu2movm

Dear Editor, Misinformation has been a major global challenge in the COVID-19 pandemic. Several therapies relevant to dermatology have been falsely touted as beneficial, including hydroxychloroquine.

Ivermectin is a synthetic derivative of a class of antiparasitics known as avermectins, discovered by the Irish Nobel Prize winner William Campbell in 1978. Ivermectin has broad-spectrum activity against a variety of endoparasites and ectoparasites. It selectively binds to parasitic neurotransmitter receptors, inducing paralysis in the targeted parasite. It blocks trans-synaptic chemical transmission through glutamate-gated anion channels ( Fig. 1) , which are not present in vertebrates. At higher concentrations, ivermectin can interact with other ligand-gated chloride channels.

Ivermectin is approved to treat several parasitic infestations with cutaneous tropism, in both oral and topical formulation ( Table 1) . It is commonly used in the treatment of resistant or crusted scabies, as a second-line strategy in cases of suspected permethrin resistance, or when topical treatment is not feasible. Ivermectin also Demodex folliculorum, a human skin commensal, can cause facial or disseminated demodecidosis, and is responsive to ivermectin. Ivermectin is also commonly used in a topical formulation to treat papulopustular rosacea, given the role of Demodex in the pathophysiology of this condition. Cutaneous larva migrans and cutaneous larva currens can be treated with single-dose ivermectin. Myiasis, filariasis, onchocerciasis and loiasis have varying reponses to ivermectin.

Ivermectin has been shown to have in vitro antiviral activity against a variety of viruses, including both RNA and DNA viruses. 5 The mechanism considered to be responsible for this antiviral effect is the inhibition of integrase protein and importin a/b1 heterodimer, which are part of a key intracellular transport process that viruses hijack to enhance infection by suppressing the host's antiviral response. 5 In addition, ivermectin docking may interfere with the attachment of the SARS-CoV-2 spike protein to the human cell membrane. 5 However, the concentration of drug needed to kill viruses in vitro is up to 100 times higher than the concentration of ivermectin normally used in vivo to control parasitic disease in humans. Some studies of ivermectin have reported potential anti-inflammatory properties, which may be beneficial in people with COVID-19. 5 Ivermectin is generally a safe and efficacious therapy for its dermatological indications. However, despite reported antiviral effects at supratherapeutic doses in vitro, there is neither clinical evidence nor a plausible biological mechanism to support ivermectin as an effective prophylactic or therapeutic agent against SARS-CoV-2. It is important that healthcare professionals understand the lack of evidence for its application to COVID-19, and continue to refute and rebut misleading health information. 

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