key: cord-0940723-0yhnw6ot
authors: Song, Wuhui; Jia, Xiaofang; Zhang, Xiaonan; Ling, Yun; Yi, Zhigang
title: Co-infection in COVID-19, a cohort study
date: 2020-10-08
journal: J Infect
DOI: 10.1016/j.jinf.2020.10.006
sha: 0d4dc2a71aa53752bff3fb6aa6ee13cf5831c145
doc_id: 940723
cord_uid: 0yhnw6ot

nan

Co-infection in COVID-19 patients may inflence the outcome of the disease and needs more attention and investigations. In this journal, Lansbury and colleges reported a meta-analysis of co-infections in COVID-19 patients. 1 In this study, we investigated a COVID-19 cohort in Shanghai, China. We screened viruses include Human parainfluenza virus 1 Nine patients showed severe or critical symptoms. As reported, age is a risk factor for severe symptoms (Table 1) M. catarrhalis typically infect adults with a weakened immune system. 4 Elderly COVID-19 patients have impaired Cytotoxic CD8+ T Cell Responses, which may make them highly risk for infection. 5 A. baumannii is a common pathogen in Intensive Care Units (ICU) and evolves rapidly to be resistant to many antibiotics and should be seriously considered for critical COVID-19 patients. 6 In summary, we carried out an extensive pathogen screening in a COVID-19 cohort.

We didn't detect co-infection of SARS-CoV-2 with other viruses. Co-infection with bacteria was detected in 18 of the 89 patients. M. catarrhalis was detected in two patients with severe symptoms and A. baumannii was detected in one patient with critical symptoms. These bacterial co-infections should be taken care in managing the COVID-19 patients. 

PR China Running title: Co-infection in COVID-19

Shanghai public health clinical center

Shanghai public health clinical center

Co-infections in people with COVID-19: a systematic review and meta-analysis

Observations about symptomatic and asymptomatic infections of 494 patients with COVID-19 in Shanghai, China

Viral and host factors related to the clinical outcome of COVID-19

Impaired cytotoxic CD8 1 + T cell response in elderly COVID-19 patients. mBio

Emergence of carbapenem-resistant Acinetobacter baumannii as the major cause of ventilator-associated pneumonia in intensive care unit patients at an infectious disease hospital in southern Vietnam

This study was approved by the ethics committee of Shanghai public health clinical center under the study number YJ-2020-S077-02, and the procedures were carried out in accordance with approved guidelines

The authors declare no conflicts of interest.