key: cord-0940668-2yf2ux9k
authors: Wang, Lei; Ding, Jinfeng; Stacey, Glyn N; Hao, Jie
title: The Chinese National Stem Cell Resource Center
date: 2020-09-17
journal: Stem Cell Res
DOI: 10.1016/j.scr.2020.101985
sha: c5ffc456a482d21b449c9d677c783a8492b9615b
doc_id: 940668
cord_uid: 2yf2ux9k

The Chinese National Stem Cell Resource Center was first established in 2007 and has progressed to produce and prepare stocks of more than 400 human embryonic stem cell lines. Its facilities are accredited to international standards and it has accreditation as a supplier of cells for research and therapy. The NSCRC also has an active program of translational research and strong collaborations with the Institute of Zoology and the Academy for Stem Cells and Regeneration of the Chinese Academy of Sciences. Its translational research extends to early stage clinical studies and it also has a strong training and public education program.

Based on the development of high quality pluripotent stem cell lines, NSCRC has actively engaged in collaborations with major stem cell research institutions in China, to develop or improve relevant technologies, which can then be used to benefit the entire stem cell research community. NSCRC serves as a hub to set up networks of national stem cell resources and preclinical research. To promote clinical application of stem cells in the near future, NSCRC is also working hard to provide high-level resources, services, and support for worldwide stem cell researchers and institutions.

The NSCRC has an internal program of work delivering cell banks and differentiation protocols as part of a clinical translation effort to treat age-related macular degeneration (Liu, Xu et al. 2018 ), recurrent uterine adhesion (Cao et al. 2018 A new goal of NSCRC is to establish a pluripotent stem cell registry in China that will expand the international reach of the hPSCreg project (wwww.hpscreg.eu/) share cell line data with other registries, harmonize procedures and enable communication. NSCRC is an international partner in the hPSCreg project for which its tasks include definition of new information fields to add to the database, acquisition and registration of Chinese cell line information according to the defined requirements agreed in cooperation with other national registries and banks.

The Bank currently holds multiple clinical-grade human embryonic stem cells (Gu, Wang et al. 2017 ) and induced pluripotent stem cells (Wang, Hao et al. 2015; Li, Ma et al. 2018) , which provides an important resource for both basic and clinically oriented research. Furthermore, NSCRC has also developed a range functional differentiated from human embryonic stem cells.

These include neural progenitor cells and neurons (Wang, Zhu et al. 2018 

In addition to providing cell resources, NSCRC also provides services to the outside community, such as stem cell technology training, organization of a national science forum on stem cells and public outreach activities on stem cell research.

So far, NSCRC has organized 30 training courses and hundreds of students have been trained.

The training has covered many aspects of stem cell science, from basic to clinical research.

Training formats have included experimental operation and theoretical knowledge, focused on the isolation and culture of hESC and tissue-specific progenitor/stem cells (MSCs).

Several sessions of the National Science Forum on Stem Cells have also been held, with thousands of participants mainly from universities, research institutes and hospitals.

In order to communicate stem cell technology and science to the public, we welcome high school and primary school students to come into the NSCRC laboratories, including high school students for laboratory practice. NSCRC also formed the 'popular science group' delivering popular science exhibitions and held numerous popular science report meetings open to the public (more than 300 reports up to o 2018).

Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial

Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations

A fully defined static suspension culture system for large-scale human embryonic stem cell production

Human embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration

Comparative analysis of mesenchymal stem cells derived from amniotic membrane, umbilical cord and chorionic plate under serum-free condition

General requirements for the quality and competence of biobanking), Intrenational Standards Organisation

Generation of clinical-grade functional cardiomyocytes from human embryonic stem cells in chemically defined conditions

Generation of clinical-grade human induced pluripotent stem cells in Xeno-free conditions

The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies

Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease