key: cord-0939540-g7w9eakg
authors: Larrosa‐Garcia, Maria; Garcia‐Garcia, Sonia; Los‐Arcos, Ibai; Moreso, Francesc; Berastegui, Cristina; Castells, Lluís; Gorgas Torner, Maria Q.; Miarons, Marta
title: Long‐term effects of COVID‐19 in solid organ transplantation recipients
date: 2021-07-12
journal: Transpl Infect Dis
DOI: 10.1111/tid.13677
sha: c919721275717da0e19ab25e6271f6dad85a95d5
doc_id: 939540
cord_uid: g7w9eakg

A few months ago, we presented the results from a case-control study evaluating solid organ transplantation (SOT) recipients' outcomes after COVID-19 requiring hospitalization, which showed a trend towards higher mortality among SOT patients compared to controls1 . Other authors reported similar results regarding mortality2 , whereas Chavarto et al. found no increased risk of death among kidney recipients compared to controls3 . We hypothesize that COVID-19 might affect long-term survival of SOT recipients, drug-drug interactions (DDI) might contribute to graft rejection and COVID-19 unknown long-term effects might specially affect immunosuppressed patients4 ; here, we aim to evaluate the long-term outcomes of SOT patients affected by COVID-19.

To the Editor:

A few months ago, we presented the results from a case-control study evaluating solid organ transplantation (SOT) recipients' outcomes after COVID-19 requiring hospitalization, which showed a trend toward higher mortality among SOT patients compared to controls. 1 Other authors reported similar results regarding mortality, 2 whereas Chavarto et al found no increased risk of death among kidney recipients compared to controls. 3 We hypothesize that COVID-19 might affect long-term survival of SOT recipients, drug-drug interactions (DDI) might contribute to graft rejection, and COVID-19 unknown long-term effects might specially affect immu- SOT recipients might have higher susceptibility to COVID-19persistent symptoms; moreover, COVID-19 and drugs used to treat it might enhance graft rejection and opportunistic infections, even if we did not detect any case of rejection. Further information is required to completely understand COVID-19 long-term impact in general population and specifically on SOT recipients.

COVID-19 in solid organ transplantation: a matched retrospective cohort study and evaluation of immunosuppression management

Incidence and outcome of SARS-CoV-2 infection on solid organ transplantation recipients: a nationwide population-based study

Critical COVID-19 France Investigators. COVID-19 severity in kidney transplant recipients is similar to nontransplant patients with similar comorbidities

Short-and potential longterm adverse health outcomes of COVID-19: a rapid review

Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values

Long-term effects of COVID-19 in solid organ transplantation recipients

Creatinine and tacrolimus trough plasma concentration of SOT recipients during the follow up (X axis represent the correlative number of blood sample during the follow up, m: month, SOT: solid organ transplantation