key: cord-0938644-df702h9m
authors: Coen, Matteo; Jeanson, Grégoire; Alejandro Culebras Almeida, L.; Hübers, Annemarie; Stierlin, Florian; Najjar, Iris; Ongaro, Marie; Moulin, Kelly; Makrygianni, Maria; Leemann, Béatrice; Kronig, Ilona; Bertrand, Jérôme; Reny, Jean-Luc; Schibler, Manuel; Serratrice, Jacques
title: Guillain-Barré Syndrome as a Complication of SARS-CoV-2 Infection
date: 2020-04-28
journal: Brain Behav Immun
DOI: 10.1016/j.bbi.2020.04.074
sha: 8050d5f15ba864abde2f23392034f6a93920a99c
doc_id: 938644
cord_uid: df702h9m

nan

A man in his seventies was hospitalized because of paraparesis, distal allodynia, difficulties in voiding and constipation. Ten days before he developed myalgia, fatigue, and a dry cough. He Before the SARS-CoV-2 pandemic, only two cases of coronavirus-associated GBS were reported in the literature: a man with MERS-CoV who developed Bickerstaff brainstem encephalitis (a variant of GBS) 4 , and a boy who developed an atypical GBS after a respiratory infections sustained by HCoV-OC43 5 . Up to now, two paper have described a possible association between SARS-CoV-2 and GBS. 6, 7 We describe one of the first cases of GBS occurring in the context of SARS-CoV-2 infection.

In the context of the current pandemic, clinicians should be aware that GBS can complicate SARS-CoV-2 infection an affect patient's outcomes, thus requiring a prompt intervention.

Moreover, physician should remember that that the incidence of GBS during outbreaks of infectious disease can increase (as with the recent Zika virus epidemic). 8 To note, although neurological manifestation in COVID-19 are frequently described (like in the recent case report by Ye et al. 9 ), the neuroinvasive potential of SARS-CoV-2 remains hitherto inexplored. 10 

Timeline indicating the main events of the patient's illness. Top row: clinical events (before/after patient's hospitalisation)

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