key: cord-0938377-2ez03i4p
authors: Gu, Xiaoyu; Chen, Xiang; Shen, Minxue
title: Association of psoriasis with risk of COVID-19: A two-sample Mendelian randomization study
date: 2022-02-04
journal: J Am Acad Dermatol
DOI: 10.1016/j.jaad.2022.01.048
sha: f1178b0d5d6497fcd048dddefd9dd9840e271229
doc_id: 938377
cord_uid: 2ez03i4p

nan

To the Editor, 19 from genetic and epidemiological perspectives, 1 randomly assigned to offspring to simulate the causal relationships between exposures and outcomes. 51

Here, we performed a two-sample MR, in which genetic associations with the exposure and outcome 52 are estimated in different sets of individuals, to investigate the association of psoriasis with COVID-19. 53

We downloaded the summary data from open-access GWAS datasets at https://gwas.mrcieu.ac.uk/. 54

We used R 4.0.4 and package 'TwoSampleMR' and statistical methods could be found in the guidelines 55 (https://mrcieu.github.io/TwoSampleMR). We used the inverse variance weighted (IVW) method as 56 the primary approach and other algorithms as the supplementary methods. We then tested the pleiotropy 57 using the MR-Egger regression since valid MR estimations require IVs to be independent of outcomes. 58

Finally, reverse MR and sensitivity analysis were used to test the unidirection and robustness of the 59 results, respectively. P<0.05 was considered statistically significant. 60

For psoriasis, we extracted the results from studies by Neale lab with 3,871 cases and 333,288 61 controls to generate the IVs (https://gwas.mrcieu.ac.uk/datasets/ukb-a-100/). For COVID-19, the data confounded by socioeconomic, environmental, and behavioral factors, and the timing of causality is 74 reasonable. The finding could be conducive to comprehending the underlying impacts of psoriasis on 75 the phenotype of COVID-19. Previous studies have revealed that patients with psoriasis would probably 76 bring about an increased risk of developing severe infections; this may be due to the use of 77 immunosuppressants such as methotrexate. 5 Future research could concentrate on assessing the effects 78 of systemic drugs such as immunosuppressants on the association of psoriasis with COVID-19. 79

Associations between COVID-19 and skin conditions 82 identified through epidemiology and genomic studies

Hospitalization and Mortality in Patients with Psoriasis: A Population-Based Study

The Risk of COVID-19 Pandemic in Patients with 87

Moderate to Severe Plaque Psoriasis Receiving Systemic Treatments. Vaccines (Basel)