key: cord-0938197-6al2qtpb authors: Alberti, Paola; Beretta, Simone; Piatti, Marco; Karantzoulis, Aristotelis; Piatti, Maria Luisa; Santoro, Patrizia; Viganò, Martina; Giovannelli, Ginevra; Pirro, Fiammetta; Montisano, Danilo Antonio; Appollonio, Ildebrando; Ferrarese, Carlo title: Guillain-Barré syndrome related to COVID-19 infection date: 2020-04-29 journal: Neurol Neuroimmunol Neuroinflamm DOI: 10.1212/nxi.0000000000000741 sha: 4d8002a25e4c938229dc342fce1e0e654181ef99 doc_id: 938197 cord_uid: 6al2qtpb nan A 71-year-old male patient was referred to the emergency department for subacute onset of paresthesia at limb extremities, followed by distal weakness rapidly evolving to a severe, flaccid tetraparesis over the previous 3 days. In the previous week, he had low grade fever for a few days. Relevant conditions at his medical history included hypertension, abdominal aortic aneurysm treated with endovascular repair in 2017, and lung cancer treated with surgery only (without additional chemotherapy or radiotherapy) in 2017 with negative oncological follow-up; no previous neurologic history was reported. Neurologic examination showed normal consciousness and language, no cranial nerve deficit, symmetric limb weakness (Medical Research Council score 3/5 at upper limbs and 2/5 at lower limbs), symmetric and extensive stocking-and-glove hypesthesia at the 4 limbs (more pronounced at lower limbs), absent deep tendon reflexes, and normal plantar response. The patients complained of severe paresthesia in both hands and feet. Moderate dyspnea and moderate low back pain were present at the time of the first evaluation. He showed hemodynamic disturbances with severe drug-resistant hypertension. Arterial blood gases indicated severe hypoxia (paO2 65 mm Hg without supplemental oxygen). Brain CT scan was normal, whereas chest CT scan showed multiple bilateral ground glass opacities and consolidations, typical of COVID-19 pneumonia. Nasopharyngeal swab tested positive for SARS-CoV-2. Lumbar puncture was performed urgently and showed a mild increase in the protein content (54 mg/dL) and mild leukocytosis (9 cells/μL); CSF was negative for SARS-CoV-2. Electroneurography showed the absence of both the sural nerve sensory nerve action potential (SAP) and the tibial nerve compound muscle action potential (CMAP), markedly increased common peroneal CMAP distal latency, markedly decreased velocity, moderately decreased CMAP amplitude (with spatial and temporal dispersion) for the same nerve, and decreased ulnar SAP amplitude. F waves were not performed at lower limbs for the reduced amplitude of the evocable CMAP and not performed at upper limbs for intolerance at the stimulation. See table for a summary of nerve conduction studies results. Overall, these findings were interpreted as a severe form of acute polyradiculoneuritis with prominent demyelinating features. Diagnosis of Guillain-Barré syndrome (GBS) associated with COVID-19 was made. High-dose IV immunoglobulins (0.4 g/kg/d for 5 days) were started few hours after admission, together with high-flow 60%-80% oxygen via nonrebreather mask, antiviral therapy (lopinavir + ritonavir), and hydroxychloroquine. Despite these efforts, severe respiratory failure developed during the first 24 hours after admission, unresponsive to continuous positive airway pressure ventilation and prone positioning. The patient died a few hours later because of progressive respiratory failure. The authors report a possible correlation between acute COVID-19 infection and GBS, a condition that in recent years has been linked to other emergent infections, such as Zika virus. 4 Our case suggests that COVID-19 may cause peripheral nervous system involvement, even before the resolution of pneumonia, meeting the diagnostic criteria of an acute sensory and motor polyradiculoneuritis. Dysregulation of the immune system due to COVID-19 is not that surprising because McGonagle et al. 5 recently described systemic hyperinflammation in COVID-19 patients with a macrophage activation syndrome, also known as secondary hemophagocytic lymphohistiocytosis; notably, Quin et al. 6 also retrospectively evaluated a cohort of 452 patients with COVID-19 observing alterations in lymphocytes. Early respiratory support, including ICU admission, is indicated but not always feasible during the current pandemic. The authors agree that a close attention to neurologic complications of COVID-19 is needed, as recently suggested by Mao et al. 7 The Italian Society of Neurology is currently proposing a multicenter nationwide observational study on neurologic presentations and complications of COVID-19. Similar efforts by other neurologic societies worldwide will benefit both neurologists and patients at a global level. The convalescent sera option for containing COVID-19 Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Zika virus infection as a cause of congenital brain abnormalities and Guillain-barré syndrome: systematic review Interleukin-6 use in COVID-19 pneumonia related macrophage activation syndrome Dysregulation of immune response in patients with COVID-19 in Wuhan, China Neurological manifestations of hospitalized patients with COVID-19 in Wuhan, China: a retrospective case series study We thank Giuseppina Resta for her technical assistance for nerve conduction studies. This study was supported by the Italian Ministry of University and Research grant PRIN 2017CY3J3W. The authors have nothing to disclose. Go to Neurology.org/ NN for full disclosures. Received by Neurology: Neuroimmunology & Neuroinflammation April 2, 2020. Accepted in final form April 13, 2020.